Search results for "IPR"
showing 10 items of 1515 documents
Differential Effects of Fluvoxamine and Other Antidepressants on the Biotransformation of Melatonin
2001
Melatonin, the predominant product of the pineal gland, is involved in the maintenance of diurnal rhythms. Nocturnal blood concentrations of melatonin have been shown to be enhanced by fluvoxamine, but not by other serotonin reuptake inhibitors. Because fluvoxamine is an inhibitor of several cytochrome P450 (CYP) enzymes, the authors studied the biotransformation of melatonin and the effects of fluvoxamine on the metabolism of melatonin in vitro using human liver microsomes and recombinant human CYP isoenzymes. Melatonin was found to be almost exclusively metabolized by CYP1A2 to 6-hydroxymelatonin and N-acetylserotonin with a minimal contribution of CYP2C19. Both reactions were potently in…
Antidepressants are functional antagonists at the serotonin type 3 (5-HT3) receptor
2003
Antidepressants are commonly supposed to enhance serotonergic and/or noradrenergic neurotransmission by inhibition of neurotransmitter reuptake through binding to the respective neurotransmitter transporters or through inhibition of the monoamine oxidase. Using the concentration-clamp technique and measurements of intracellular Ca2+, we demonstrate that different classes of antidepressants act as functional antagonists at the human 5-HT3A receptor stably expressed in HEK 293 cells and at endogenous 5-HT3 receptors of rat hippocampal neurons and N1E-115 neuroblastoma cells. The tricyclic antidepressants desipramine, imipramine, and trimipramine, the serotonin reuptake inhibitor fluoxetine, t…
An Integrated Multi-service Software Simulation Platform: SIMPSONS Architecture
2005
This paper describes SIMPSONS (SIp and MPls Simulations On NS-2), which is a software platform for simulating multiple network scenarios, such as Telephony Over IP (TOIP), and multi-services networks extending the functionalities of Network Simulator NS-2. The innovative aspects of SIMPSONS is the complete integration of control protocols and traffic engineering mechanisms inside the same simulation tool. In fact, next generation networks must meet basically two fundamental requirements: support of Quality of Service (QoS) and Traffic Engineering (TE) functionalities. SIMPSONS is able to simulate DiffServ, MPLS, OSPF and SIP and their interaction in everything TOIP scenario. So with this po…
Two new sesquiterpene lactones from Montanoa tomentosa ssp. microcephala
2001
BIOLOGY OF THE WREN, TROGLODYTES TROGLODYTES, IN A MEDITERRANEAN INSULAR AGROECOSYSTEM
2009
In the last years many species of birds have exploited urban and suburban habitats, taking opportunistically advantage of human presence for their niche parameters. The Wren is one of them and shows a high variability in the choice of nesting sites in the gardens of the outskirts of Palermo (Sicily). For many years the authors studied the breeding habits of this small bird, and thanks to the video-tape recordings on the nests, they were able to gather new information on its feeding habits and parental care. They could establish the role played by both parents, the different prey types carried to the chicks, and other data, scarcely known in the southern part of distribution of this passerin…
Effetto di tre diversi edible coating a base di gel di Aloe vera sulla qualità di frutti di kiwi di IV gamma
2021
Negli ultimi anni, il mercato della frutta di IV gamma si è contraddistinto per una crescita esponenziale legata ai ritmi di vita più intensi rispetto al passato, che spingono a privilegiare prodotti offerti in porzioni, utilizzabili in modo facile e veloce. La frutta di IV gamma è caratterizzata, però, da una breve durata di conservazione a causa delle fasi di lavorazione e preparazione che accelerano i processi di maturazione. Lo scopo di questo lavoro è stato quello di analizzare sulla qualità di kiwi della varietà “Hayward” in IV gamma l’effetto di tre diversi rivestimenti commestibili basati su (1) Aloe vera gel (AVG), (2) Aloe vera gel + idrossipropilmetilcellulosa (HPMC), (3) Aloe ve…
Aspetti riproduttivi di Hoplostethus mediterraneus nel mediterraneo centrale
2008
ROLE OF BEHAVIOUR IN MARINE ORGANISMS: POTENTIAL EFFECTS UNDER FUTURE OCEAN CONDITIONS.
2021
Over the last 250 years, the intensive burning of fossil fuels along with industrial processes and land uses (e.g. clearing forests and agriculture) has contributed to an increase in atmospheric CO2 from approximately 280 to 410 ppm, with a further increase (from 730 to 1020 ppm) projected by the end of this century. About 30% of the anthropogenic CO2 has been absorbed by the ocean, with a consequent decrease of the ocean’s surface pH causing a phenomenon better known as Ocean Acidification (OA). The average pH of the surface ocean has declined from 8.2 by 0.1 units since pre-industrial times as a result of CO2 emissions and a further reduction of 0.3–0.5 pH units is expected to occur by th…
RIPRISTINO DEI FONDALI DEGRADATI E RECUPERO DEL PAESAGGIO SOMMERSO NELL’AREA MEDITERRANEA
Sistema biocompatibile di supporto per la piantumazione di organismi vegetali in ambiente marino
2010
Il brevetto consiste in un sistema a basso impatto ambientale, realizzato interamente in bioplastica, per il fissaggio sul fondo marino in forma rapida ed efficace di organismi vegetali, allo scopo di garantirne l'attecchimento e la crescita, assecondandone la dinamica naturale di sviluppo.