Search results for "IPR"
showing 10 items of 1515 documents
SYNTHESIS AND ANTIPROLIFERATIVE ACTIVITY OF 3-AMINO-N-PHENYL-1H-INDAZOLE-1-CARBOXAMIDES
2010
Recently our research group has reported the synthesis of some 3-amino-N-phenyl-1H-indazole-1-carboxamides able to inhibit at low micromolar concentrations the cell growth of many neoplastic cell lines. The above compounds are unsubstituted in the indazole nucleus and this gives the hope to obtain more active compounds if appropriate substituents are beared by the above nucleus. So, several new N-phenyl-1H-indazole-1-carboxamides 1c-h and 4l,m were prepared by reacting phenyl isocyanates 3a,b with 3-amino-1H-indazoles 2c,e,g, or 1H-indazole 2l respectively. Chemical trasformations of compounds 1a,b and 1g,h gave 3-acetamido-N-phenyl-1H-indazole-1-carboxamides 5a,b, and 3,5-diamino-N-phenyl-…
Synthesis, antiproliferative activity and possible mechanism of action of novel 2-acetamidobenzamides bearing the 2-phenoxy functionality.
2015
Several new 2-(2-phenoxyacetamido)benzamides 17a-v, 21 and 22 were synthesized by stirring in pyridine the acid chlorides 16a-e and the appropriate5-R-4-R1-2-aminobenzamide 15a-e and initially evaluated in vitro for antiproliferative activity against the K562 (human chronic myelogenous leukemia) cell line. Some of synthesized compounds were evaluated for their in vitro antiproliferative activity against the full NCI tumor cell line panel derived from nine clinically isolated cancer types (leukemia, non-small cell lung, colon, CNS, melanoma, ovarian, renal, prostate and breast). The most active compounds caused an arrest of K562 cells in the G0-G1 phase of cell cycle and induction of apoptos…
"Table 1" of "Measurement of the low-energy antideuteron inelastic cross section"
2020
Raw primary antiproton-to-proton ratio as a function of the momentum p_primary.
"Table 7" of "Measurement of the low-energy antideuteron inelastic cross section"
2020
Raw primary antiproton-to-proton ratio from Geant4-based MC simulations as a function of the momentum p_primary with sigma_inel(pbar)0.75.
"Table 5" of "Measurement of the low-energy antideuteron inelastic cross section"
2020
Raw primary antiproton-to-proton ratio from Geant4-based MC simulations as a function of the momentum p_primary with default sigma_inel(pbar).
"Table 6" of "Measurement of the low-energy antideuteron inelastic cross section"
2020
Raw primary antiproton-to-proton ratio from Geant4-based MC simulations as a function of the momentum p_primary with sigma_inel(pbar)x1.25.
"Table 12" of "Measurement of the low-energy antideuteron inelastic cross section"
2020
Inelastic interaction cross section of antiprotons on an averaged material element of the ALICE detector (2 sigma constraints).
"Table 10" of "Measurement of the low-energy antideuteron inelastic cross section"
2020
Inelastic interaction cross section of antiprotons on an averaged material element of the ALICE detector (2 sigma constraints).
"Table 11" of "Measurement of the low-energy antideuteron inelastic cross section"
2020
Inelastic interaction cross section of antiprotons on an averaged material element of the ALICE detector (1 sigma constraints).
"Table 9" of "Measurement of the low-energy antideuteron inelastic cross section"
2020
Inelastic interaction cross section of antiprotons on an averaged material element of the ALICE detector (1 sigma constraints).