Search results for "IR M"
showing 10 items of 151 documents
Dynamics of fungal colonization in a new medical mycology laboratory
2012
International audience; Objective of the study. - Study of the spatio-temporal fungal colonization in a new medical mycology laboratory. Methods. - A 17-month survey of airborne fungal contamination was conducted in a new medical mycology laboratory at a tertiary care university hospital. This survey was implemented at three different periods: before the new premises were occupied (period A), during the move into the new laboratory (period B) and after resumption of the mycological activities in these new premises (period C). Results. - During period A, the airborne fungal load ranged from 2.3 to 6 cfu/m(3). The most frequently recovered airborne fungi were Penicillium spp. (75 to 100%). Du…
Mechanisms of human DNA repair: an update.
2003
The human genome, comprising three billion base pairs coding for 30000-40000 genes, is constantly attacked by endogenous reactive metabolites, therapeutic drugs and a plethora of environmental mutagens that impact its integrity. Thus it is obvious that the stability of the genome must be under continuous surveillance. This is accomplished by DNA repair mechanisms, which have evolved to remove or to tolerate pre-cytotoxic, pre-mutagenic and pre-clastogenic DNA lesions in an error-free, or in some cases, error-prone way. Defects in DNA repair give rise to hypersensitivity to DNA-damaging agents, accumulation of mutations in the genome and finally to the development of cancer and various metab…
Repair of O(6)-methylguanine is not affected by thymine base pairing and the presence of MMR proteins.
2001
Methylation at the O(6)-position of guanine (O(6)-MeG) by alkylating agents is efficiently removed by O(6)-methylguanine-DNA methyltransferase (MGMT), preventing from cytotoxic, mutagenic, clastogenic and carcinogenic effects of O(6)-MeG-inducing agents. If O(6)-MeG is not removed from DNA prior to replication, thymine will be incorporated instead of cytosine opposite the O(6)-MeG lesion. This mismatch is recognized and processed by mismatch repair (MMR) proteins which are known to be involved in triggering the cytotoxic and genotoxic response of cells upon methylation. In this work we addressed three open questions. (1) Is MGMT able to repair O(6)-MeG mispaired with thymine (O(6)-MeG/T)? (…
Income and expenses of Jan Karol Chodkiewicz (1686–1712), starost of Veliuona, Zabłudów, Baisogala and Daugeliskis, relating to his schooling in Wars…
2021
Postać Jana Karola Chodkiewicza (1686–1712) z linii supraskiej nie doczekała się do tej pory swojego opracowania choćby w postaci noty biograficznej. Artykuł niniejszy przybliża więc wybrany fragment z życiorysu wyżej wymienionego bohatera, który w latach 1700–1705 przebywał na naukach w szkole jezuickiej w Warszawie. Okres nauk stanowił ważne wydarzenie w życiu młodych magnatów, którzy w ich ramach przygotowywali się do służby państwowej i funkcjonowania w społeczeństwie szlacheckim. Nie inaczej było w przypadku Jana Karola, dziedzica ogromnej fortuny chodkiewiczowskiej, który resztę swojego krótkiego życia spędził później na sporach o dobra ojczyste. Młody starosta pobierał nauki w trudny…
A multidisciplinary approach to the study of cultural heritage environments: Experience at the Palatina Library in Parma
2015
The aim of this paper is to describe a multidisciplinary approach including biological and particle monitoring, and microclimate analysis associated with the application of the Computational Fluid Dynamic (CFD). This approach was applied at the Palatina historical library in Parma. Monitoring was performed both in July and in December, in the absence of visitors and operators. Air microbial monitoring was performed with active and passive methods. Airborne particles with a diameter of ≥0.3, ≥0.5, ≥1 and ≥5 μm/m3, were counted by a laser particle counter. The surface contamination of shelves and manuscripts was assessed with nitrocellulose membranes. A spore trap sampler was used to identify…
Jan Karol Chodkiewicz (1686–1712) – szkic biograficzny młodego magnata
2021
Artykuł stanowi próbę zaprezentowania postaci Jana Karola Chodkiewicza z linii supraskiej (1686–1712), syna starosty błudeńskiego i oboźnego wielkiego litewskiego Jerzego Karola Chodkiewicza oraz Marianny Tekli z Naruszewiczów, który do tej pory nie doczekał się żadnego szerszego opracowania naukowego. Podstawę źródłową szkicu biograficznego Chodkiewicza stanowią materiały przechowywane w Archiwum Narodowym w Krakowie, w zespole Archiwum Młynowskie Chodkiewiczów. Różnorodność znajdujących się w nim dokumentów pozwoliła na możliwie jak najdokładniejsze odtworzenie jego życiorysu. Z niego wyłania się postać Jana Karola, który osierocony przez ojca w dzieciństwie zdany był na opiekę swojej mat…
Modifications in Water Resources Availability Under Climate Changes: A Case Study in a Sicilian Basin
2014
Climate variability due to the greenhouse effect has important implications on hydrological processes and water resources systems. Indeed, water availability, quality and streamflow are very sensitive to changes in temperature and precipitation regimes whose effects have to be fully considered in current water management and planning. International literature proposes several models, attempting to assess accurately the available water resources under stationary and changing climatic conditions at different spatial and temporal scales. In order to assess the potential impacts of climate change on surface and groundwater resources water availability in a Southern area of Italy, a conceptual h…
A new model for estimating diffuse solar radiation in Italy from clearness index and minimum air mass
1990
The aim of this study is: (a) to propose a new simple model for estimating the monthly mean daily diffuse radiation D, MJ m−2 day−1, using as input only the clearness index Kt and minimum air mass and (b) to develop a map of diffuse solar radiation incident on a horizontal surface in Italy. The correlation herein suggested is D = 5.6 Kt−0.55 (sin hn)1.58 where hn is the noon altitude of the sun on the 15th of the month, in degrees, and Kt = G/H0; G and H0 are the monthly mean daily global and extraterrestrial solar radiation respectively. This equation is applied to Adrano, Palermo, Macerata and Genova stations, provided with measured data of global and diffuse radiation, and the relative c…
Effect of the relative optical air mass and the clearness index on solar erythemal UV irradiance
2014
This paper analyses the effects of the clearness index (Kt) and the relative optical air mass (mr) on erythemal UV irradiance (UVER). The UVER measurements were made in Valencia (Spain) from 6:00 am to 6:00 pm between June 2003 and December 2012 and (140,000 data points). Firstly, two models were used to calculate values for the erythemal ultraviolet irradiance clearness index (KtUVER) as a function of the global irradiance clearness index (Kt). Secondly, a potential regression model to measure the KtUVER as a function of the relative optical air mass was studied. The coefficients of this regression were evaluated for clear and cloudy days, as well as for days with high and low ozone levels…
Dust mobilization and transport in the northern Sahara during SAMUM 2006 – a meteorological overview
2009
The SAMUM field campaign in southern Morocco in May/June 2006 provides valuable data to study the emission, and the horizontal and vertical transports of mineral dust in the Northern Sahara. Radiosonde and lidar observations show differential advection of air masses with different characteristics during stable nighttime conditions and up to 5-km deep vertical mixing in the strongly convective boundary layer during the day. Lagrangian and synoptic analyses of selected dust periods point to a topographic channel from western Tunisia to central Algeria as a dust source region. Significant emission events are related to cold surges from the Mediterranean in association with eastward passing upp…