Search results for "IRI"

CORTE DI CASSAZIONE; sezione III penale; sentenza 23 maggio - 14 novembre 2013, n. 45468; Pres. LOMBARDI, Est. Grillo, PM Lettieri (concl. diff.); ri…

2014

Nota di richiami alla pronuncia CORTE DI CASSAZIONE; sezione III penale; sentenza 23 maggio - 14 novembre 2013, n. 45468; Pres. LOMBARDI, Est. Grillo, PM Lettieri (concl. diff.); ric. U., ove annullando parzialmente App. Roma 25 maggio 2012, si afferma che la ricerca di un contatto con lo stalker da parte della vittima del reato di atti persecutori, non contrastando col concetto di stress enunciato dalla norma incriminatrice, non esclude la configurabilità del delitto di cui all’art. 612 bis c.p.; tuttavia, nelle ipotesi di reciprocità dei comportamenti molesti, incombe sul giudice un più accurato onere di motivazione in ordine alla sussistenza dello stato d’ansia o di paura della persona o…

New developments in the management of hepatitis C virus infection: focus on boceprevir

2012

Chronic hepatitis C virus infection is an important public health problem, and the standard treatment (combination of pegylated interferon-α and ribavirin) has an effectiveness rate of only 40%-50%. Novel virus-specific drugs have recently been designed, and multiple compounds are under development. The approval for the clinical use of direct-acting antivirals in 2011 (boceprevir [BOC] and telaprevir, viral NS3 protease inhibitors) has increased recovery rates by up to 70%. Therefore, a highly effective treatment has been envisioned for the first time. This paper focuses on BOC and the implementation of new BOC-based treatment regimes.

Musiikin vaikutus ikääntyneiden asukkaiden hyvinvointiin kahdessa jyväskyläläisessä palvelutalossa

2010

"Kyllä mullakin vuosiluvut heittelee, mutta silti on muuten vaan hauskaa!" : sadutuksen merkitys dementiatyössä

2008

Rapid detection and discrimination of fabaviruses by flow-through hybridisation with genus- and species-specific riboprobes

2015

Viruses cause significant damage in agricultural crops worldwide. Disease management requires sensitive and specific tools for virus detection and identification. Also, detection techniques need to be rapid to keep pace with the continuous emergence of new viral diseases. The genus Fabavirus is composed of five viruses infecting many economically important crops worldwide. This research describes the development of a procedure based on flow-through hybridisation (FTH), which is faster than and as sensitive as conventional hybridisation for virus detection in tissue-prints from infected plants. Six digoxigenin-labelled RNA probes were synthesised with two levels of specificity: (a) five spec…

Amaya, A., Michelon, C. (eds.) (2020), The faces of virtue in law. Routledge

2022

The book, edited by Amalia Amaya and Claudio Michelon, brings together the most significant voices of the Aretaic theory to operate an interesting reconstruction of new topics in the field of philosophy of law which are typically overlooked by traditional legal theory. This approach allows the exploration of new interpretative lines that may suggest further developments for the theory of virtue. Reading this book could therefore be a valid and interesting tool for all those who study the legal decision-making process from a philosophical perspective, but also for all jurists who deal, in a broader sense, with the legal practice.

Vaginal infection of mice with HSV type 2 variant ER−: A new animal model for human primary genital HSV type 2 infections

1992

Abstract Studying the pathogenesis of vaginal infections in mice with two variants of Herpes simplex virus type 2 (HSV-2) strain ER we observed that both variants ER+ and ER− caused severe vaginitis but only ER+ invaded the CNS leading to lethal neurological disease. In contrast, mice infected with ER− cleared the virus from the vagina and recovered from infection. ER+ and ER− expressed equal levels of thymidine kinase (TK) indicating a TK-independent difference in neurovirulence. Using the non-neurovirulent variant ER−, we were able to investigate humoral immune responses late after infection. Vaginal infection with ER− suppressed serum antibody formation after a secondary systemic HSV-1 i…

Peptide-mediated interference with baculovirus transduction

2007

Baculovirus represents a multifunctional platform with potential for biomedical applications including disease therapies. The importance of F3, a tumor-homing peptide, in baculovirus transduction was previously recognized by the ability of F3 to augment viral binding and gene delivery to human cancer cells following display on the viral envelope. Here, F3 was utilized as a molecular tool to expand understanding of the poorly characterized baculovirus-mammalian cell interactions. Baculovirus-mediated transduction of HepG2 hepatocarcinoma cells was strongly inhibited by coincubating the virus with synthetic F3 or following incorporation of F3 into viral nucleocapsid by genetic engineering, th…

Occlusion-derived baculovirus: interaction with human cells and evaluation of the envelope protein P74 as a surface display platform.

2008

To develop complementary baculovirus-based tools for gene delivery and display technologies, the interaction of occlusion-derived baculovirus (ODV) with human cells, and the functionality of the P74 ODV envelope protein for display of the IgG-binding Z domains (ZZP74) were evaluated. The cellular binding of ODV was concentration-dependent and saturable. Only minority of the bound virions were internalized at both 37 and 4 degrees C, suggesting usage of direct membrane fusion as the entry mode. The intracellular transport of ODV was confined in vesicular structures peripheral to the plasma membrane, impeding subsequent nuclear entry and transgene expression. Transduction of ODV was not rescu…

Mouse models of cytomegalovirus latency: overview.

2002

Abstract Background: The molecular regulation of viral latency and reactivation is a central unsolved issue in the understanding of cytomegalovirus (CMV) biology. Like human CMV (hCMV), murine CMV (mCMV) can establish a latent infection in cells of the myeloid lineage. Since mCMV genome remains present in various organs after its clearance from hematopoietic cells first in bone marrow and much later in blood, there must exist one or more widely distributed cell type(s) representing the cellular site(s) of enduring mCMV latency in host tissues. Endothelial cells and histiocytes are candidates, but the question is not yet settled. Another long debated problem appears to be solved: mCMV establ…