Search results for "IRI"

GRAd-COV2, a gorilla adenovirus-based candidate vaccine against COVID-19, is safe and immunogenic in younger and older adults

2022

International audience; Safe and effective vaccines against coronavirus disease 2019 (COVID-19) are essential for ending the ongoing pandemic. Although impressive progress has been made with several COVID-19 vaccines already approved, it is clear that those developed so far cannot meet the global vaccine demand alone. We describe a COVID-19 vaccine based on a replication-defective gorilla adenovirus expressing the stabilized prefusion severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein named GRAd-COV2. We assessed the safety and immunogenicity of a single-dose regimen of this vaccine in healthy younger and older adults to select the appropriate dose for each age group…

Is molecular mimicry the culprit in the autoimmune haemolytic anaemia affecting patients with COVID‐19?

2020

Performance Assessment of Critical Thinking: Conceptualization, Design, and Implementation

2020

Enhancing students’ critical thinking (CT) skills is an essential goal of higher education. This article presents a systematic approach to conceptualizing and measuring CT. CT generally comprises the following mental processes: identifying, evaluating, and analyzing a problem; interpreting information; synthesizing evidence; and reporting a conclusion. We further posit that CT also involves dealing with dilemmas involving ambiguity or conflicts among principles and contradictory information. We argue that performance assessment provides the most realistic—and most credible—approach to measuring CT. From this conceptualization and construct definition, we describe one possible framework for …

Nenukleozīdu HIV – 1 reversās transkriptāzes inhibitoru sintēze

2016

Nenukleozīdu HIV – 1 reversās transkriptāzes inhibitoru sintēze. Pustenko A., zinātniskie vadītāji Dr. chem. Žalubovskis R, Dr. chem. Igors Kļimenkovs. Maģistra darbs 71 lappuses, 58 attēli, 20 tabulas, 33 literatūras avoti. Latviešu valodā. Darbā tika sintezēti 3,4-dihidropirimidīn-2(1H)-oni un to mono- N-1 un N-1, N-3 bisatvasinājumi reakcijās ar virkni sulfonilhlorīdu un acilhlorīdu. Sintezēto savienojumu struktūra apstiprināta ar KMR spektriem, kā arī ar Rentgenstruktūranalīzi. Literatūras apskatā apkopota informācija par 3,4-dihidropirimidīn-2(1H)-onu sintēzes metodēm, to acilēšanu un sulfonilēšanu.

Lukemisvaikeuksien ilmeneminen suomalaisilla 3.-6.-luokkalaisilla oppilailla

2007

Critical points in open sublevels and multiple solutions for parameter-depending quasilinear elliptic equations

2014

We investigate the existence of multiple nontrivial solutions of a quasilinear elliptic Dirichlet problem depending on a parameter $\lambda>0$ of the form $$ -\Delta_pu=\lambda f(u)\quad\mbox{in }\ \Omega,\quad u=0\quad\mbox{on }\ \partial\Omega, $$ where $\Omega\subset \mathbb{R}^N$ is a bounded domain, $\Delta_p$, $1 < p < +\infty$, is the $p$-Laplacian, and $f: \mathbb{R}\to \mathbb{R}$ is a continuous function satisfying a subcritical growth condition. More precisely, we establish a variational approach that when combined with differential inequality techniques, allows us to explicitly describe intervals for the parameter $\lambda$ for which the problem under consideration admits nontri…

Teacher Training for Children with Autism Spectrum Disorders in Finland

2019

This chapter first provides a short description of the historical background and development of special education teacher training in Finland. The relationship between special education and teaching pupils with autism spectrum disorder (ASD) is covered by chronologically presenting the main events, turning points, publications, and people that have had a significant effect on the education of pupils with ASD in Finland. This is followed by a description of the organization of teacher training, in general, and the particular characteristics of teaching pupils with ASD. In the context of ASD, it is essential to examine questions concerning the link between learning as social practice and the …

Hilbert space operators with two-isometric dilations

2021

A bounded linear Hilbert space operator $S$ is said to be a $2$-isometry if the operator $S$ and its adjoint $S^*$ satisfy the relation $S^{*2}S^{2} - 2 S^{*}S + I = 0$. In this paper, we study Hilbert space operators having liftings or dilations to $2$-isometries. The adjoint of an operator which admits such liftings is characterized as the restriction of a backward shift on a Hilbert space of vector-valued analytic functions. These results are applied to concave operators (i.e., operators $S$ such that $S^{*2}S^{2} - 2 S^{*}S + I \le 0$) and to operators similar to contractions or isometries. Two types of liftings to $2$-isometries, as well as the extensions induced by them, are construct…

Annual pollen traps reveal the complexity of climatic control on pollen productivity in Europe and the Caucasus

2010

Annual PAR (pollen accumulation rates; grains cm−2 year−1) were studied with modified Tauber traps situated in ten regions, in Poland (Roztocze), the Czech Republic (two regions in Krkonoše, two in Šumava), Switzerland (4 regions in the Alps), and Georgia (Lagodekhi). The time-series are 10–16 years long, all ending in 2007. We calculated correlations between pollen data and climate. Pollen data are PAR summarized per region (4–7 traps selected per region) for each pollen type (9–14 per region) using log-transformed, detrended medians. Climate data are monthly temperature and precipitation measured at nearby stations, and their averages over all possible 2- to 6-month windows falling within…

Audiovisuaalisen puheen hyödyntäminen lasten kielihäiriön kuntoutuksessa

2020

Peer reviewed