Search results for "IRP"
showing 10 items of 206 documents
Embryonic adhesion is not affected by endometrial leptin receptor gene silencing.
2006
Objective In rodents, evidence suggests that the leptin system is mandatory for embryonic implantation. We aimed to investigate the functional relevance of the endometrial leptin receptor (OB-R) in the adhesion phase of human implantation. Design We used an in vitro model for embryonic adhesion, composed of a human endometrial cell line (HEC1-A) and B6C3F1 mouse embryos. The OB-R gene was silenced in a stable manner by RNA interference, and embryonic adhesion rates were analyzed. Setting Research laboratory at a university-affiliated center. Intervention(s) RNA interference. Main Outcome Measure(s) Embryonic adhesion in cells treated with OB-R RNAi. Result(s) The OB-R shRNA-transfected cell…
Ravinteiden vaikutus vesikirpun (Daphnia longispina) loisintaan Mekkojärvellä
2010
Voimakkaasti humuksisessa Mekkojärvessä Daphnia longispina hallitsee järven eläinplanktonia läpi kesän. Daphnioiden kasvu hidastuu loppukesää kohti kasviplanktonin määrän vähetessä, ja ravinnosta jopa 73 % koostuu bakteeriplanktonista, jonka katsotaan olevan heikompi ravinnonlähde Daphnioille. Isännän ravitsemuksen laadulla voi olla joko positiivisia tai negatiivisia vaikutuksia vesikirpun loisintaan ja sen runsauteen. Lammin Mekkojärvellä selvitettiin ravinnelisäyksen välillistä vaikutusta vesikirppujen loisintaan kuuden viikon mittaisessa ravinnemanipulaatiokokeessa kuudessa mesokosmoksessa kesällä 2008. Kolme mesokosmosta sai viikottaisen epäorgaanisen typpi- ja fosforilisäyksen ja kolme…
Toxicity of biomining effluents to Daphnia magna : Acute toxicity and transcriptomic biomarkers
2018
Increasing metal consumption is driving the introduction of new techniques such as biomining to exploit low grade ores. The biomining impacts notably aquatic ecosystems, yet, the applicability of ecotoxicological tests to study the complex mixture effects of mining waters is insufficiently understood. The aim of the present work was to test if transcriptomic biomarkers are suitable and sensitive for the ecotoxicity assessment of biomining affected waters. The study site had been affected by a multimetal biomine, and the studied water samples formed a concentration gradient of contamination downstream from the biomining site. Cadmium and nickel were used as positive controls in the toxicity …
Multicriteria Decision Aiding for Planning Renewable Power Production at Moroccan Airports
2022
This study is about multicriteria decision aiding (MCDA) for the green airports program of the Moroccan Airport Authority ONDA. The goal of the program is to develop significant amounts of renewable power at airports. In particular, ONDA wants to select airports at which large solar and wind power parks should be built. Multiple criteria, including economy, technical feasibility, and environmental concerns, must be considered simultaneously. In this study, we apply Stochastic Multicriteria Acceptability Analysis (SMAA) for ranking the candidates to be developed into green airports. The analysis is conducted in phases with different sets of criteria. This study is the first application of MC…
Ruumiinkokemusten eettisiä avauksia : myyttien uudelleenkirjoitukset Saila Susiluodon ja Sirpa Kyyrösen runoissa
2015
Tarkastelen pro gradu -tutkielmassani lähiluvun keinoin, millaisia naisruumiinkokemuksia Saila Susiluodon Siivekkäät ja Hännäkkäät (2001) ja Sirpa Kyyrösen Naispatsaita (2010)-runokokoelmista on luettavissa. Molemmissa teoksissa naisruumiinkokemuksia tuodaan esille myyttejä ja satuja uudelleenkirjoittamalla. Myyttien ja satujen uudelleenkirjoitukset puolestaan haastavat lukijan mukaan eettiseen dialogiin runoissa esitetyn ruumistematiikan kanssa tarjoamalla kulttuurisia mallikertomuksia epäileviä, kyseenalaistavia tai vastustavia lukija-asemia. Tutkielmani rakentuu johdantoluvusta, kirjallisuustieteellisestä artikkelista ja artikkelikäsikirjoituksen pohjalta laaditusta englanninkielisestä e…
Efficiency of Daphnia magna in removal of green microalgae cultivated in Nordic recirculating aquaculture system wastewater
2020
The increase of global aquaculture production has boosted the development of recirculating aquaculture systems not only because they reduce water use but also provide opportunities for waste management and the use of released nutrients. The dissolved nutrients can be efficiently removed from recirculating aquaculture system wastewater by microalgae, and microalgae can be harvested from the wastewater with low costs by zooplankton such as Daphnia. The purpose of this study was to evaluate the feasibility of using microalgae and Daphnia for bioremediation of recirculating aquaculture system wastewater in Nordic conditions. We evaluated the growth and filtration efficiency of the waterflea Dap…
Induction of body weight loss through RNAi-knockdown of APOBEC1 gene expression in transgenic rabbits
2014
In the search of new strategies to fight against obesity, we targeted a gene pathway involved in energy uptake. We have thus investigated the APOB mRNA editing protein (APOBEC1) gene pathway that is involved in fat absorption in the intestine. The APOB gene encodes two proteins, APOB100 and APOB48, via the editing of a single nucleotide in the APOB mRNA by the APOBEC1 enzyme. The APOB48 protein is mandatory for the synthesis of chylomicrons by intestinal cells to transport dietary lipids and cholesterol. We produced transgenic rabbits expressing permanently and ubiquitously a small hairpin RNA targeting the rabbit APOBEC1 mRNA. These rabbits exhibited a moderately but significantly reduced …
Responses of zooplankton to cane sugar additions to a small humic lake, Alinen Mustajärvi
2010
The response to projected increase in dissolved organic carbon (DOC) loading to boreal lakes is being studied in lake Alinen Mustajärvi, a small humic lake in southern Finland, where labile DOC concentration has been artificially increased during 2008 and 2009 by monthly additions of cane sugar. As part of this wider project, in this thesis the responses of the zooplankton community to cane sugar addition were studied. Zooplankton samples were collected monthly in the ice-free periods of 2007, 2008 and 2009 and the mean densities and mean carbon biomasses of rotifers and crustacean zooplankton (cladocerans and copepods) were calculated. Stable isotope analyses (δ13C and δ15N) were made for …
Quando le garanzie cedono all'ideologia: il diritto penale inquinato dalla legislazione razziale fascista
2021
Furthermore, Fascism produces deep wounds in the development of criminal law. The introduction of the racial corpus becomes a Trojan horse capable of breaching all guarantees. Clear data emerges: the persecution of the Jews takes place primarily outside the parameters of criminal law, but the normatives in defense of the lineage will actually favor racial laws. Mirroring the formal permanence system of liberal guarantees is a stance taken by many criminal lawyers who, in some cases, seem to take a different position than those imposed by the regime, but only in legal journals circulating in the academic field and without any impactful influence on political decisions. There are at least thr…
Measuring phenotypes in fluctuating environments
2020
Despite considerable theoretical interest in how the evolution of phenotypic plasticity should be shaped by environmental variability and stochasticity, how individuals actually respond to these aspects of the environment within their own lifetimes remains unclear. We propose that this understanding has been hampered by experimental approaches that expose organisms to fluctuating environments (typically treatments where fluctuations in the environment are cyclical vs. erratic) for a pre‐determined duration, while ensuring that the mean environment over that the entire exposure period is invariable. This approach implicitly assumes that responses to the mean and variance/predictability in th…