Search results for "IRT"

Off-Target-Based Design of Selective HIV-1 PROTEASE Inhibitors

2021

The approval of the first HIV-1 protease inhibitors (HIV-1 PRIs) marked a fundamental step in the control of AIDS, and this class of agents still represents the mainstay therapy for this illness. Despite the undisputed benefits, the necessary lifelong treatment led to numerous severe side-effects (metabolic syndrome, hepatotoxicity, diabetes, etc.). The HIV-1 PRIs are capable of interacting with “secondary” targets (off-targets) characterized by different biological activities from that of HIV-1 protease. In this scenario, the in-silico techniques undoubtedly contributed to the design of new small molecules with well-fitting selectivity against the main target, analyzing possible undesirabl…

Modulation of impulsive behaviours using transcranial random noise stimulation

2021

A systematic review of immersive virtual reality applications for higher education: Design elements, lessons learned, and research agenda

2019

Abstract Researchers have explored the benefits and applications of virtual reality (VR) in different scenarios. VR possesses much potential and its application in education has seen much research interest lately. However, little systematic work currently exists on how researchers have applied immersive VR for higher education purposes that considers the usage of both high-end and budget head-mounted displays (HMDs). Hence, we propose using systematic mapping to identify design elements of existing research dedicated to the application of VR in higher education. The reviewed articles were acquired by extracting key information from documents indexed in four scientific digital libraries, whi…

Neighbourhood socio-economic characteristics and the risk of preterm birth for migrant and non-migrant women: a study in a French district

2011

Neighbourhood-level deprivation is associated with preterm birth; preterm birth rates are also higher for some, but not all migrant groups. We studied the impact of neighbourhood characteristics (a deprivation score and the proportion of foreign-born residents) on singleton preterm birth in the French district of Seine-Saint-Denis for women born in France, North Africa, sub-Saharan Africa and other countries. Multilevel logistic regression models were adjusted for maternal demographic and health care characteristics. For women born in France, the preterm birth rate rose with neighbourhood deprivation quintile (3.8% in the first to 5.7% in the fifth, adjusted odds ratio: 1.40 [95% confidence…

Enhancement of Anticipatory Postural Adjustments by Virtual Reality in Older Adults with Cognitive and Motor Deficits: A Randomised Trial.

2021

Background: Postural activities involved in balance control integrate the anticipatory postural adjustments (APA) that stabilize balance and posture, facilitating arm movements and walking initiation and allowing an optimal coordination between posture and movement. Several studies reported the significant benefits of virtual reality (VR) exercises in frail older adults to decrease the anxiety of falling and to induce improvements in behavioural and cognitive abilities in rehabilitation processes. The aim of this study was thus to test the efficiency of a VR system on the enhancement of the APA period, compared to the use of a Nintendo Wii system. Methods: Frail older adults (n = 37) were i…

Effects of maternal singing during kangaroo care on maternal anxiety, wellbeing, and mother-infant relationship after preterm birth: a mixed methods …

2020

Introduction: Preterm birth may disturb the typical development of the mother– infant relationship, when physical separation and emotional distress in the neonatal intensive care unit may increase maternal anxiety and create challenges for early interaction. This cluster-randomized controlled trial examined the effects of maternal singing during kangaroo care on mothers’ anxiety, wellbeing, and the early mother– infant relationship after preterm birth. Method: In the singing intervention group, a certified music therapist guided the mothers (n = 24) to sing or hum during daily kangaroo care during 33–40 gestational weeks (GW). In the control group, the mothers (n = 12) conducted daily kanga…

Cold-water immersion combined with active recovery is equally as effective as active recovery during 10 weeks of high-intensity combined strength and…

2019

Summary Study aim: The purpose of this study was to compare the effects of cold-water immersion (CWI) vs. active recovery performed after each individual strength and endurance training session over a 10-week period of high-intensity combined strength and endurance training. Materials and methods: Seventeen healthy men completed 10 weeks of high-intensity combined strength and endurance training. One group (AR, n = 10) completed active recovery that included 15 minutes of running at 30–40% VO2max after every strength training session while the other group (CWI, n = 7) completed 5 minutes of active recovery (at the same intensity as the AR group) followed by 10 minutes of cold-water (12 ± 1°…

Artefact co-construction in virtual exchange: 'Youth Entrepreneurship for Society'

2020

The aim of this research study around the co-construction and sharing of authentic and meaningful artefacts within the 'Youth Entrepreneurship for Society' virtual exchange was to find out how the implementation of artefact-based telecollaborative tasks fosters 21st competences and social entrepreneurship in English for Specific Purposes settings. The project tasks were informed by constructionism and supported virtual collaboration an effort to promote social justice. They revolved around social entrepreneurship in English for Specific Purposes contexts, aiming to connect the classroom with the outside world through the involvement of local organisations, while fostering students' twenty-f…

ELF and migrant categorization at family clinics in Finland

2019

Artikkelin tavoite on selvittää, miten neuvolan terveydenhoitajat käyttävät puheessaan kieltä, erityisesti englannin kieltä, ei-suomea-puhuvien asiakkaidensa kategorisointiin. Tutkimuksessa hyödynnetään jäsenkategoria-analyysiä (Schegloff, Emanuel A. 2007. A tutorial on membership categorization. Journal of Pragmatics 39(3). 462–482) osoittamaan, miten englannin kielen osaaminen maahanmuuttostatuksen ja syntyperäisen englannin puhujan normin ohella näytti olevan määräävin tekijä siinä, miten terveydenhoitajat kategorisoivat siirtolaistaustaisia asiakkaitaan. Tutkimustulokset osoittavat kuinka vahvasti jäsenkategoriapohjainen luokittelu näkyy institutionaalisessa päätöksenteossa, ja ne koros…

Combining expertise from linguistics and tourism: a tale of two cities

2020

This case study presents the results of an interdisciplinary Virtual Exchange (VE) that was arranged between Finnish and Polish students in 2019. During their six-week collaboration, the students of language studies at the University of Jyväskylä, Finland, worked in teams together with their Polish peers specialising in information and communications technology and management in tourism at Adam Mickiewicz University in Poznań, Poland. The international teams combined their linguistic and tourism-promotion expertise, and, using collaborative digital tools, grappled with the tasks of analysing the official municipal city websites and promoting the lesser-known aspects of their sister cities (…