Search results for "ISAR"
showing 10 items of 339 documents
Factors related to the impact of antihypertensive treatment in antioxidant activities and oxidative stress by-products in human hypertension
2004
The objective was to study factors related to the changes induced by antihypertensive treatment on oxidative status, antioxidant activities, and reactive oxygen species by-products in whole blood and mononuclear peripheral cells. Eighty-nine hypertensive patients (mean age 46 years, 46 men, average 24-h blood pressure 139/88 mm Hg, body mass index 29) were included. After 3 months of nonrandomized allocation to antihypertensive treatment (20 nonpharmacologic, 36 beta-blockers, 33 angiotensin receptor blocker), oxidized/reduced glutathione ratio and malondialdehyde were significantly reduced, and the activity of superoxide dismutase, catalase, and glutathione peroxidase was significantly inc…
The effects of telmisartan alone or in combination with hydrochlorothiazide on morning home blood pressure control: The SURGE 2 practice-based study
2013
SURGE 2, a large-scale, practice-based study in 10 countries, evaluated the effects of telmisartan alone or with hydrochlorothiazide (HCTZ) on morning (06:00 – 11:59) home blood pressure (HBP) control. Hypertensive patients (clinic blood pressure [BP] 140/90 mmHg) received telmisartan 40 or 80 mg either alone or in combination with HCTZ 12.5 mg for 8 weeks. Treatment could be adjusted if clinic BP remained 140/90 mmHg. Clinic BP was measured in the morning prior to medication, and seated HBP monitoring was performed, three times per day, 2 days per week. A total of 25,882 patients were included (71% were previously using antihypertensives). There was a statistically signifi cant (all p 0.00…
Angiotensin II antagonists - an assessment of their acute toxicity.
2013
In Germany, increasing prescription rates of angiotensin II antagonists resulted in rising enquiries to Poisons Information Centres (PICs) during the last decade. Therefore, we aimed to assess their acute toxicity for deriving triage recommendations.An observational case series with data collected retrospectively from eight PICs in Austria, Germany and Switzerland. Inclusion criteria were monoexposure, defined dose, and documented follow-up.In total, 206 cases of exposures to angiotensin II antagonists were included (candesartan, 94; eprosartan, 3; irbesartan, 20; losartan, 26; olmesartan, 16; telmisartan, 18; and valsartan, 29). The median dose expressed as a multiple of their maximum dail…
Telmisartan as metabolic modulator: a new perspective in sports doping?
2011
The World Antidoping Agency (WADA) has introduced some changes in the 2012 prohibited list. Among the leading innovations to the rules are that both 5-aminoimidazole-4-carboxamide-1-[beta]-D-ribofuranoside (peroxisome proliferator�activated receptor-[delta] [PPAR-[delta]]-5' adenosine monophosphate-activated protein kinase [AMPK] agonist) and GW1516 (PPAR-[delta]-agonist) are no longer categorized as gene doping substances in the new 2012 prohibited list but as metabolic modulators in the class �Hormone and metabolic modulators.� This may also be valid for the angotensin II receptor blocker telmisartan. It has recently been shown that telmisartan might induce similar biochemical, biological…
I diritti degli animali
2022
Il contributo affronta il tema dei diritti degli animali nell'ambito delle opere di Paolo Cendon, analizzandolo nel quadro delle fragilità esistenziali. Per danno da perdita dell’animale di affezione si intende, infatti, il danno non patrimoniale, di tipo esistenziale, derivante al proprietario dalla perdita o dal ferimento dell’animale di affezione, capace di caratterizzare e, talvolta, dominare, del tutto, la rete affettiva familiare. Non si tratta, cioè, di risarcire la lesione di un diritto alla vita dell’animale, bensì di compensare la lesione del diritto alla relazione affettiva intrattenuta con l’animale, nell’ambito della quale l’individuo può esplicare la propria personalità relazi…
I progetti di Francesco Fichera e dei fratelli Rapisardi per il Sacrario ai Caduti di Siracusa
2019
Costruito tra il 1928 e il 1937, il Sacrario dei Caduti di Siracusa rappresenta un raro esempio di architettura votiva e religiosa aI tempo stesso. L'edificio, che oggi prende il nome di Chiesa di San Tommaso al Pantheon, è dedicato al culto della memoria ed alla devozione per i Caduti della Grande Guerra. Il saggio ripercorre la storia del monumento, dalla sua concezione alla sua realizzazione, inserendolo nel più ampio contesto storico, artistico ed architettonico d'epoca e confronta i progetti dell'architetto Francesco Fichera (Catania,1881-1950) con quelli dei fratelli Gaetano ed Ernesto Rapisardi, mostrando anche alcuni materiali inediti.
The value of open-source clinical science in pandemic response
2021
International audience
AT1-receptor blockade by telmisartan upregulates GTP-cyclohydrolase I and protects eNOS in diabetic rats.
2008
Several enzymatic sources of reactive oxygen species (ROS) were described as potential reasons of eNOS uncoupling in diabetes mellitus. In the present study, we investigated the effects of AT1-receptor blockade with chronic telmisartan (25 mg/kg/day, 6.5 weeks) therapy on expression of the BH4-synthesizing enzyme GTP-cyclohydrolase I (GCH-I), eNOS uncoupling, and endothelial dysfunction in streptozotocin (STZ, 60 mg/kg iv, 7 weeks)-induced diabetes mellitus (type I). Telmisartan therapy did not modify blood glucose and body weight. Aortas from diabetic animals had vascular dysfunction as revealed by isometric tension studies (acetylcholine and nitroglycerin potency). Vascular and cardiac RO…