Search results for "ISOC"

A Versatile Synthesis of Fluorinated Uracils in Solution and on Solid-Phase.

2004

[reaction: see text] An efficient and convenient two-step synthesis of new fluorinated uracils is described. The first step involves the condensation of an ester enolate with a fluorinated nitrile to furnish fluorinated beta-enamino esters. In turn, these compounds react with organic isocyanates or isothiocyanates to give C-6 fluorinated uracils or thiouracils, respectively, in excellent yields. This synthesis has been successfully adapted to solid-phase conditions with high diversity, thereby facilitating the creation of small (thio)uracil libraries.

Pyrrolo[2,1-d][1,2,3,5]tetrazine-4(3H)-ones, a new class of azolotetrazines with potent antitumor activity.

2003

Pyrrolo[2,1-d][1,2,3,5]tetrazinones 10a-o, compounds that hold the deaza skeleton of the antitumor drug temozolomide, were prepared by reaction of 2-diazopyrroles 9 and isocyanates. Such a synthetic route represents, among those leading to azolotetrazinones reported so far, the only possible one since attempts to cyclize to the title ring system 2-amino-1-carbamoylpyrroles 11 or the mono substituted 2-triazenopyrrole 12 failed. Compounds 10 were screened at the National Cancer Institute (NCI) for their activity against a panel of about 60 human tumor cell lines. Most of them possess remarkable antineoplastic activity having GI(50) values in the low micromolar or sub-micromolar range and rea…

Homochiral oxazolidin-2-ones and imidazolidin-2-ones by tandem nucleophilic addition–conjugate addition

2004

Abstract Treatment of both primary alcohols 1a , b and secondary amines 1c , d , tethered to a Michael acceptor with ( R )-phenylethyl isocyanate in the presence of DBU gave in good yield and high stereoselection diastereomeric mixtures of oxazolidin-2-ones 2a , b and 3a , b and imidazolidin-2-ones 2c , d and 3c , d , respectively. The cyclisation reaction was studied computationally by ab initio quantum mechanical methods. The observed stereoselectivity was explained on the basis of the different stability of both anions and transition states leading to 2a and 3a , respectively. The usefulness of the method was proven by conversion of 2a into the enantiomerically pure bioactive amino acid …

An elliptic equation on n-dimensional manifolds

2020

We consider an elliptic equation driven by a p-Laplacian-like operator, on an n-dimensional Riemannian manifold. The growth condition on the right-hand side of the equation depends on the geometry of the manifold. We produce a nontrivial solution by using a Palais–Smale compactness condition and a mountain pass geometry.

Risorse psicosociali e re-impiegabilità dopo lunghi periodi di inoccupazione: il caso degli operai ex-FIAT di Termini Imerese

2016

Nel dibattito nazionale relativo al difficile equilibrio tra le esigenze delle organizzazioni lavorative e le politiche di tutela dei diritti dei lavoratori, certamente il caso del destino dello stabilimento FIAT di Termini Imerese (PA) ha avuto negli ultimi anni un ruolo di primo piano. Il presente lavoro rappresenta il primo contributo di un accordo siglato tra il Dipartimento SPPF dell'Università di Palermo, la azienda interessata al reinserimento dei lavoratori ex-FIAT (BLUTEC) e la società di consulenza incaricata di occuparsi di questo delicato processo di transizione. Tra finalità dell'accordo c'è quella di svolgere una attività di ricerca volta ad esplorare le variabili psicosociali…

Multivariable non-invasive association of isocitrate dehydrogenase mutational status in World Health Organization grade II and III gliomas with advan…

2020

Aim To investigate multivariable analyses for noninvasive association of the isocitrate dehydrogenase (IDH) mutational status in grade II and III gliomas including evaluation of T2 mapping-sequences. Methods Magnetic resonance imaging (MRI) examinations with histopathologically proven World Health Organization grade II and III gliomas were retrospectively enrolled. Multivariate receiver operating characteristics (ROC) analyses to associate IDH mutational status were performed containing quantitative T2 mapping analyses and qualitative characteristics (sex, age, localization, heterogeneity, oedema, necrosis and diameter). Relaxation times were calculated pixelwise by means of standardized RO…

PSICOPATIA E DISTURBO ANTISOCIALE DI PERSONALITÀ TRA COMPLESSITÀ DINAMICA E QUESTIONE DIAGNOSTICA

2010

Higher aggression is related to poorer academic performance in compulsory education

2019

Background To conduct a comprehensive assessment of the association between aggression and academic performance in compulsory education. Method We studied aggression and academic performance in over 27,000 individuals from four European twin cohorts participating in the ACTION consortium (Aggression in Children: Unraveling gene‐environment interplay to inform Treatment and InterventiON strategies). Individual level data on aggression at ages 7–16 were assessed by three instruments (Achenbach System of Empirically Based Assessment, Multidimensional Peer Nomination Inventory, Strengths and Difficulties Questionnaire) including parental, teacher and self‐reports. Academic performance was measu…

T2 mapping of the peritumoral infiltration zone of glioblastoma and anaplastic astrocytoma.

2021

Purpose To characterise peritumoral zones in glioblastoma and anaplastic astrocytoma evaluating T2 values using T2 mapping sequences. Materials and methods In this study, 41 patients with histopathologically confirmed World Health Organization high grade gliomas and preoperative magnetic resonance imaging examinations were retrospectively identified and enrolled. High grade gliomas were differentiated: (a) by grade, glioblastoma versus anaplastic astrocytoma; and (b) by isocitrate dehydrogenase mutational state, mutated versus wildtype. T2 map relaxation times were assessed from the tumour centre to peritumoral zones by means of a region of interest and calculated pixelwise by using a fit m…

Half-width plots, a simple tool to predict peak shape, reveal column kinetics and characterise chromatographic columns in liquid chromatography: Stat…

2013

Peak profiles in chromatography are characterised by their height, position, width and asymmetry; the two latter depend on the values of the left and right peak half-widths. Simple correlations have been found between the peak half-widths and the retention times. The representation of such correlations has been called half-width plots. For isocratic elution, the plots are parabolic, although often, the parabolas can be approximated to straight-lines. The plots can be obtained with the half-widths/retention time data for a set of solutes experiencing the same kinetics, eluted with a mobile phase at fixed or varying composition. When the analysed solutes experience different resistance to mas…