Search results for "ISSP"
showing 10 items of 15 documents
Polymorphism of Amyloid Fibrils and their Complexes with Catalase
2014
Catalase binding to amyloid fibrils has been shown for the Alzheimer’s amyloid-β (Aβ), type 2 diabetes-associated islet amyloid polypeptide (IAPP) and Creutzfeldt-Jakob disease-associated prion protein (PrP). Catalase targets a specific domain with a GAII-like sequence and there are a number of other amyloid fibril-forming proteins that contain related sequences, such as the Parkinson’s associated α-synuclein protein and the Huntington disease protein Huntingtin. Using transmission electron microscopy (TEM) analysis, interactions show specific binding of catalase to some, but not all, fibrillar forms of Aβ, IAPP and PrP fragments, allowing determination of the fibrillar forms that contain a…
Expresión de KISS1 en embarazo ectópico
2021
La implantación es el proceso por el que el embrión se orienta, adhiere y, finalmente, invade el endometrio materno, siendo un proceso clave para el éxito de la reproducción y desarrollo embrionario. Se requiere una estrecha regulación del proceso para prevenir una invasión patológica o excesiva. Existen grandes similitudes entre el proceso de invasión del citotrofoblasto (implantación) y la invasión de las células cancerígenas. Sin embargo, el proceso de implantación está regulado por una serie de procesos no del todo conocidos, que evitan una invasión celular descontrolada. Uno de los factores implicados en este proceso regulatorio es el gen KISS-1, que codifica una familia de neuropéptid…
Nestandarta pareizrakstība Instagram sludinājumos
2020
Tā kā patērētāju attieksme un cerības ir mainījušās, tradicionālā reklāmdošana ir zaudējusi daļu savas pievilcības un vērtības, liekot reklāmdevējiem meklēt jaunu pieeju. Tiešsaistes reklāmas ir īpaši efektīvas un populāras tādu sociālo mediju vietnēs kā Instagram, kas iesaista auditoriju komunikācijā un nodibina attiecības ar reklāmdevēju. Lai gan attēli ir nozīmīga daļa Instagram reklāmās, arī pievienotie ziņojumi ir svarīgi un bieži vien satur nestandarta pareizrakstību. Šī darba mērķis ir izpētīt nestandarta pareizrakstības lietojumu, nozīmi un funkcijas tiešsaistes reklāmās sociālo mediju vietnē Instagram, izmantojot diskursa analīzi kā galveno pētījuma metodi. Kvalitatīvā un kvantitat…
Comments on “Unobservable Selection and Coefficient Stability
2019
Abstract–: We establish a link between the approaches proposed by Oster (2019) and Pei, Pischke, and Schwandt (2019) which contribute to the development of inferential procedures for causal effects in the challenging and empirically relevant situation where the unknown data-generation process is not included in the set of models considered by the investigator. We use the general misspecification framework recently proposed by De Luca, Magnus, and Peracchi (2018) to analyze and understand the implications of the restrictions imposed by the two approaches.
Caracterización de la expresión y función de las taquicininas en el espermatozoide humano
2017
En nuestro país y, en general, en los países industrializados, los problemas de fertilidad son cada vez más frecuentes y actualmente se estima que entre un 15-20% de las parejas en edad reproductiva tienen problemas para concebir de manera natural. El factor masculino es responsable de aproximadamente el 40% de los casos de infertilidad. Como consecuencia de este incremento en los niveles de infertilidad, en los últimos años se han producido avances muy importantes en la medicina reproductiva y se han desarrollado una gran variedad de técnicas de reproducción asistida, pero aún queda mucho camino por recorrer. En relación a la infertilidad masculina, la prueba inicial en las clínicas de rep…
Application of the collective coordinate method to the analysis of the dynamics of mode-locked fiber lasers
2015
Mode-locked fiber laser are among the few systems that allow to achieve a variety of elaborate optical functions, by means of few optical components. The use of dispersion management brings to this type of lasers a variety of behaviors, which is so rich that the complete mapping and detailed analysis of the stable states becomes impractical when conventional tools based on the intra-cavity field propagation equations, are used. In this thesis we show that the addition of the technique ofcollective coordinates to the conventional theoretical tools, allows to solve at least in part the problem of complexity and diversity of the stable states of the cavity. In particular, we propose the DCCA (…
The opportunity of using wave energy converters in a Mediterranean hot spot
2022
The opportunity of using wave energy converter arrays in a hot spot area of the Mediterranean sea was investigated. For this purpose, numerical simulations of wave energy converters together with a simple cost-effective analysis were carried out. The selected study area is one of the most energetic inside the Sicilian channel (Italy). The numerical simulations were performed using the SNL-SWAN (“Sandia National Laboratories – Simulating WAves Nearshore”) spectral model with an unstructured mesh. The power absorbed from thirteen Wave Energy Converter (WEC) devices was computed. In particular, Pelamis, Wave Dragon, Oyster 2, Wavestar, B-HBA, B-OF, Bref-HB, Bref-SHB, F–2HB, F–3OF, F-HBA and F-…
Belief in God, Confidence in the Church and Secularization in Scandinavia
2021
We used the three latest rounds of the religion module of International Social Survey Programme to study secularization in Denmark, Norway, and Sweden, focusing on belief in God. We restricted our sample to the affiliated with the majority Protestant churches and the unaffiliated and analyzed the trends toward disaffiliation and disbelief in God. Then, we studied the association between confidence in churches, religious/secular upbringing, and demographic controls with belief in God using multinomial logistic regression models. Our treatment of belief in God as a nominal variable allowed the inclusion of both the element of doubt and different images of God in the analyses. The trends towar…
Deregulation of miR-324/KISS1/kisspeptin in early ectopic pregnancy: mechanistic findings with clinical and diagnostic implications
2019
[Abstract] BACKGROUND: Ectopic pregnancy is a life-threatening condition for which novel screening tools that would enable early accurate diagnosis would improve clinical outcomes. Kisspeptins, encoded by KISS1, play an essential role in human reproduction, at least partially by regulating placental function and possibly embryo implantation. Kisspeptin levels are elevated massively in normal pregnancy and reportedly altered in various gestational pathologic diseases. Yet, the pathophysiologic role of KISS1/kisspeptin in ectopic pregnancy has not been investigated previously. OBJECTIVE: The purpose of this study was to evaluate changes of KISS1/kisspeptin levels in ectopic pregnancy and thei…
A Large Scale Test of the Effect of Social Class on Prosocial Behavior
2015
Does being from a higher social class lead a person to engage in more or less prosocial behavior? Psychological research has recently provided support for a negative effect of social class on prosocial behavior. However, research outside the field of psychology has mainly found evidence for positive or u-shaped relations. In the present research, we therefore thoroughly examined the effect of social class on prosocial behavior. Moreover, we analyzed whether this effect was moderated by the kind of observed prosocial behavior, the observed country, and the measure of social class. Across eight studies with large and representative international samples, we predominantly found positive effect…