Search results for "Ibo"
showing 10 items of 4955 documents
SARS-CoV-2 vaccine response and rate of breakthrough infection in patients with hematological disorders
2022
Abstract Background The clinical efficacy of SARS-CoV-2 vaccines according to antibody response in immunosuppressed patients such as hematological patients has not yet been established. Patients and methods A prospective multicenter registry-based cohort study conducted from December 2020 to December 2021 by the Spanish transplant and cell therapy group was used to analyze the relationship of antibody response at 3–6 weeks after full vaccination (2 doses) with breakthrough SARS-CoV-2 infection in 1394 patients with hematological disorders. Results At a median follow-up of 165 days after complete immunization, 37 out of 1394 (2.6%) developed breakthrough SARS-CoV-2 infection at median of 77 …
High pressure theoretical and experimental analysis of the bandgap of BaMoO4, PbMoO4, and CdMoO4
2019
We have investigated the origin of the bandgap of BaMoO4, PbMoO4, and CdMoO4 crystals on the basis of optical absorption spectroscopy experiments and ab initio electronic band structure, density of states, and electronic localization function calculations under high pressure. Our study provides an accurate determination of the bandgaps Eg and their pressure derivatives d E g / dP for BaMoO4 (4.43 eV, −4.4 meV/GPa), PbMoO4 (3.45 eV, −53.8 meV/GPa), and CdMoO4 (3.71 eV, −3.3 meV/GPa). The absorption edges were fitted with the Urbach exponential model which we demonstrate to be the most appropriate for thick crystals with direct bandgaps. So far, the narrowing of the bandgap of distinct PbMoO4…
On the Road to MM′X Polymers: Redox Properties of Heterometallic Ni···Pt Paddlewheel Complexes
2014
On the quest of heterometallic mixed-valence MM'X chains, we have prepared two stable discrete bimetallic compounds: the reduced (PPN)[ClNi(μ-OSCPh)4Pt] (PPN = bis(triphenylphosphine)iminium; OSCPh = benzothiocarboxylato) and the oxidized [(H2O)Ni(μ-OSCPh)4PtCl] species. The role of the aqua and chlorido axial ligands is crucial to facilitate oxidation of the {Ni(μ-OSCPh)4Pt} core. Experimental and theoretical analyses indicate that a NiPt-Cl/Cl-NiPt isomerization process occurs in the oxidized species. The electronic structure of the reduced system shows two unpaired electrons, one located in a d(x(2)-y(2)) orbital of the Ni(II) ion and a second in the antibonding d(z(2)-dz(2)) combination…
Pharmacophore-Based Design of New Chemical Scaffolds as Translational Readthrough-Inducing Drugs (TRIDs)
2020
[Image: see text] Translational readthrough-inducing drugs (TRIDs) rescue the functional full-length protein expression in genetic diseases, such as cystic fibrosis, caused by premature termination codons (PTCs). Small molecules have been developed as TRIDs to trick the ribosomal machinery during recognition of the PTC. Herein we report a computational study to identify new TRID scaffolds. A pharmacophore approach was carried out on compounds that showed readthrough activity. The pharmacophore model applied to screen different libraries containing more than 87000 compounds identified four hit-compounds presenting scaffolds with diversity from the oxadiazole lead. These compounds have been s…
A P-chirogenic β-aminophosphine synthesis by diastereoselective reaction of the α-metallated PAMP–borane complex with benzaldimine
2004
International audience; The diastereoselective synthesis of a P-chirogenic β-aminophosphine ligand with carbon–carbon bond formation of the ethano bridge in a 3:1 ratio via reaction of an α-metallated P-chirogenic phosphine borane with a benzaldimine is described. The diastereoselectivity is attributed to a transition state where the lithium cation chelates the phosphine borane carbanion and the nitrogen of the imine and the attack of the C@N occurs on the face opposite to the P–B bond, due to its interaction with the antibonding P–B bond. The major diastereoisomeric β-aminophosphine borane was then separated and decomplexed into the corresponding β-aminophosphine under neutral conditions a…
High-grade metamorphism and partial melting of basic and intermediate rocks
2016
Rocks of basic and intermediate bulk composition occur in orogenic terranes from all geological time periods and are thought to represent significant petrological components of the middle and lower continental crust. However, the former lack of appropriate thermodynamic models for silicate melt, amphibole and clinopyroxene that can be applied to such lithologies at high temperature has inhibited effective phase equilibrium modelling of their petrological evolution during amphibolite- and granulite facies metamorphism. In this work, we present phase diagrams calculated in the Na2O–CaO–K2O–FeO–MgO–Al2O3–SiO2–H2O–TiO2–O2 (NCKFMASHTO) compositional system for a range of natural basic and interm…
Geochemistry of Noble Gases and CO2 in Fluid Inclusions From Lithospheric Mantle Beneath Wilcza Góra (Lower Silesia, Southwest Poland)
2018
Knowledge of the products originating from the subcontinental lithospheric mantle (SCLM) is crucial for constraining the geochemical features and evolution of the mantle. This study investigated the chemistry and isotope composition (noble gases and CO2 ) of fluid inclusions (FI) from selected mantle xenoliths originating from Wilcza Góra (Lower Silesia, southwest Poland), with the aim of integrating their petrography and mineral chemistry. Mantle xenoliths are mostly harzburgites and sometimes bear amphiboles, and are brought to the surface by intraplate alkaline basalts that erupted outside the north-easternmost part of the Eger (Ohře) Rift in Lower Silesia. Olivine (Ol) is classified int…
Phlogopite-pargasite coexistence in an oxygen reduced spinel-peridotite ambient
2021
AbstractThe occurrence of phlogopite and amphibole in mantle ultramafic rocks is widely accepted as the modal effect of metasomatism in the upper mantle. However, their simultaneous formation during metasomatic events and the related sub-solidus equilibrium with the peridotite has not been extensively studied. In this work, we discuss the geochemical conditions at which the pargasite-phlogopite assemblage becomes stable, through the investigation of two mantle xenoliths from Mount Leura (Victoria State, Australia) that bear phlogopite and the phlogopite + amphibole (pargasite) pair disseminated in a harzburgite matrix. Combining a mineralogical study and thermodynamic modelling, we predict …
Reconstructing caribou seasonal biogeography in Little Ice Age (late Holocene) Western Alaska using intra-tooth strontium and oxygen isotope analysis
2019
Abstract The palaeobiogeography of key prey-species can provide valuable insights into animal-human interactions, human subsistence activities and landscape use in the past. In many contemporary indigenous Arctic societies, caribou (Rangifer tarandus spp.) are an important seasonal subsistence species, and recent climatic shifts have influenced the seasonal and spatial distribution and migrations of herds. The impact of larger scale climatic change on this species, such as that experienced during the Little Ice Age (LIA), is not known, but may provide vital clues about future variability. Here we present sequential strontium (87Sr/86Sr) and oxygen (δ18OCO3) isotope data from archaeological …
Broadleaf deciduous forest counterbalanced the direct effect of climate on Holocene fire regime in hemiboreal/boreal region (NE Europe)
2017
Abstract Disturbances by fire are essential for the functioning of boreal/hemiboreal forests, but knowledge of long-term fire regime dynamics is limited. We analysed macrocharcoal morphologies and pollen of a sediment record from Lake Lielais Svētiņu (eastern Latvia), and in conjunction with fire traits analysis present the first record of Holocene variability in fire regime, fuel sources and fire types in boreal forests of the Baltic region. We found a phase of moderate to high fire activity during the cool and moist early (mean fire return interval; mFRI of ∼280 years; 11,700–7500 cal yr BP) and the late (mFRI of ∼190 years; 4500–0 cal yr BP) Holocene and low fire activity (mFRI of ∼630 y…