Search results for "Icing"
showing 10 items of 491 documents
Another Look on Choosing Factors: The International Evidence
2019
Extending Fama and French’s (2018) U.S. study on choosing factors to international equity markets, we test nested and non-nested asset pricing models for North America, Europe, Asia excluding Japan, and Japan. For non-nested models, we propose a new simulation methodology using a blocks bootstrap approach that takes into account factor dependencies. The resultant out-of-sample Sharpe ratios across all models and countries are lower than Fama and French’s pairs bootstrap approach. While we confirm that the six-factor model with market, size, and small size spread factors for value, profit, investment, and momentum produces the highest maximum squared Sharpe ratio in most economies, an except…
Isolation and characterization of two T-box genes from sponges, the phylogenetically oldest metazoan taxon
2003
It is now well established that all metazoan phyla derived from one common ancestor, the hypothetical Urmetazoa. Due to the basal position of Porifera (Demospongiae) in the phylogenetic tree of Metazoa, studies on the mechanisms controlling the development of these animals can provide clues on the understanding of the origin of multicellular animals and on how the first organization of the body plan evolved. In this report we describe the isolation and genomic characterization of two T-box genes from the siliceous sponge Suberites domuncula. The phylogenetic analysis classifies one into the subfamily of Brachyury, Sd-Bra, and the second into the Tbx2 subfamily, Sd-Tbx2. Analyses of the Sd-B…
Electoral opportunism and water pricing with incomplete transfer of control rights
2020
One of the forms of intervention in public services that lie beyond market forces is price control. While such regulation is justified by the need to achieve social goals, empirical evidence has sh...
The southernmost beech (Fagus sylvatica) forests of Europe (Mount Etna, Italy): ecology, structural stand-type diversity and management implications
2013
The southernmost European beech forests are located in the upper forest vegetation belt on Mount Etna volcano. Their standstructural patterns were analysed to assess the effects of the site-ecological factors and previous management practices on the forest structure. Five main structural-silvicultural types were identified among the main beech forest types: coppice, highmountain coppice (HMCo), high forest, coppice in conversion to high-forest and non-formal stand. A detailed standstructural analysis was carried out through measured dendrometric parameters and derived structural characters linked to both the horizontal and the vertical profiles. Plant regeneration processes were also assess…
NineTeen Complex-subunit Salsa is required for efficient splicing of a subset of introns and dorsal-ventral patterning
2020
© 2020 Rathore et al. This article is distributed exclusively by the RNASociety for the first 12 months after the full-issue publication date (see http://rnajournal.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
Investigating the Molecular Mechanism of H3B-8800: A Splicing Modulator Inducing Preferential Lethality in Spliceosome-Mutant Cancers.
2021
The SF3B1 protein, part of the SF3b complex, recognizes the intron branch point sequence of precursor messenger RNA (pre-mRNA), thus contributing to splicing fidelity. SF3B1 is frequently mutated in cancer and is the target of distinct families of splicing modulators (SMs). Among these, H3B-8800 is of particular interest, as it induces preferential lethality in cancer cells bearing the frequent and highly pathogenic K700E SF3B1 mutation. Despite the potential of H3B-8800 to treat myeloid leukemia and other cancer types hallmarked by SF3B1 mutations, the molecular mechanism underlying its preferential lethality towards spliceosome-mutant cancer cells remains elusive. Here, microsecond-long a…
The SWI/SNF subunits BRG1 affects alternative splicing by changing RNA binding factor interactions with RNA
2019
AbstractBRG1 and BRM are ATPase core subunits of the human SWI/SNF chromatin remodelling complexes. The function of the SWI/SNF complexes in transcriptional initiation has been well studied, while a function in alternative splicing has only been studied for a few cases for BRM-containing SWI/SNF complexes. Here, we have expressed BRG1 in C33A cells, a BRG1 and BRM-deficient cell line, and we have analysed the effects on the transcriptome by RNA sequencing. We have shown that BRG1 expression affects the splicing of a subset of genes. For some, BRG1 expression favours exon inclusion and for others, exon skipping. Some of the changes in alternative splicing induced by BRG1 expression do not re…
Sulphur Stored in Forest Soils and the Relative Importance of Organic and Inorganic Forms. Examples from Mont-Lozère (Southern Massif Central)
1995
From studies initiated in 1981, the mean annual hydrochemical budget established in three experiment watersheds at Mont-Lozere demonstrated that sulphur is retained in soils and in arenaceous formations (Lelong et al. 1990). Soils were developed on weathered granite materials that were strongly reworked by periglacial processes. One watershed is covered with grasses (Bassin de la Cloutasse) and the two others by forest. A beech coppice (Fagus sylvatica L.) and a Norway spruce forest (Picea abies (L.) Karst., hereafter shortened to “spruce”) occupy the Bassin de La Sapine (54 ha) and the Bassin of La Latte (20 ha), respectively. Unfortunately, as a result of a parasite attack, a large part o…
Growth in Average Firm Size of U.S. Industrial Portfolios and the Cross-Section of Expected Returns
2018
This paper shows that growth in average firm size in U.S. industrial portfolios predicts future growth in average firm size. Moreover, the payoffs of industrial portfolios sorted by growth in average firm size in the previous period increase linearly as we move from lowest to highest growth in average firm size. The spread between highest and lowest growth in average firm size is economically large and cannot be explained by exposures to standard risk factors or the asset growth effect (Cooper, Gulen, and Schill, 2008). Principal component analysis reveals that this growth in average firm size effect is linked to the first principal component. Moreover, stochastic discount factor model anal…
Jump-diffusion models of German stock returns
1991
This paper discusses the statistical properties of jump-diffusion processes and reports on parameter estimates for the DAX stock index and 48 German stocks with traded options. It is found that a Poisson-type jump-diffusion process can explain the high levels of kurtosis and skewness of observed return distributions of German stocks. Furthermore, we demonstrate that the return dynamics of the DAX include a statistically significant jump component except for a few sample subperiods. This finding is seen to be inconsistent with asset pricing models assuming that the jump component of the stock's return is unsystematic and diversifiable in the market portfolio.