Search results for "IgD-CD27-"

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CARATTERIZZAZIONE FENOTIPICA E FUNZIONALE DELLE CELLULE B (CD19+), PLASMACELLULE (CD38+++) DOPPIO NEGATIVE (IgD-CD27-) SU SANGUE MIDOLLARE NEI PAZIEN…

2014

CD19+IgD-CD27-CELLULE B DOPPIO NEGATIVECD38+++
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Double Negative (CD19+IgG+IgD-CD27-) B Lymphocytes: A New Insight from Telomerase in Healthy Elderly, in Centenarian Offspring, and in Alzheimer’s Di…

2014

Background: We have previously reported the increase of IgD-CD27- (Double Negative, DN) B cell population in the aged. These memory B cells have short telomeres and poor abilities to proliferate in vitro. Here, we investigated whether the low ability of DN B cells to proliferate depends on the expression levels of the CD307d and CD22 inhibitory receptors or whether DN B cells can proliferate and reactivate telomerase by the engagement of both innate and adaptive immune receptors. Methods: Phenotypic analyses were made by using flow cytometry. Quantitative analysis of telomerase activity was made by using a TRAP and a photometric enzyme immunoassay in young, healthy elderly, centenarian offs…

AdultTelomeraseAgingImmunologyPopulationNaive B cellB-Lymphocyte SubsetsReceptors Antigen B-CellCentenarian offspringLymphocyte ActivationSeverity of Illness IndexCD19ImmunophenotypingYoung AdultAlzheimer DiseasemedicineIgD-CD27- (Double Negative DN) B cell population in the aged DN B cell telomerase activity in young elderly CO and AD patientsImmunology and AllergySettore MED/05 - Patologia ClinicaHumanseducationTelomeraseB cellCellular SenescenceAgedInflammationSettore MED/04 - Patologia GeneraleAged 80 and overeducation.field_of_studyCD40biologyB lymphocyteAge FactorsTLR9ImmunosenescenceMiddle Agedmedicine.anatomical_structurePhenotypeImmunologyAntigens Surfacebiology.proteinAlzheimerAging; Telomerase; B lymphocytes; Alzheimer; Centenarian offspring; InflammationSettore MED/26 - NeurologiaImmunologic Memory
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