Search results for "Ilici"

Secondary structure and dynamics study of the intrinsically disordered silica-mineralizing peptide P5S3during silicic acid condensation and silica de…

2017

The silica forming repeat R5 of sil1 from Cylindrotheca fusiformis was the blueprint for the design of P5 S3 , a 50-residue peptide which can be produced in large amounts by recombinant bacterial expression. It contains 5 protein kinase A target sites and is highly cationic due to 10 lysine and 10 arginine residues. In the presence of supersaturated orthosilicic acid P5 S3 enhances silica-formation whereas it retards the dissolution of amorphous silica (SiO2 ) at globally undersaturated concentrations. The secondary structure of P5 S3 during these 2 processes was studied by circular dichroism (CD) spectroscopy, complemented by nuclear magnetic resonance (NMR) spectroscopy of the peptide in …

Comparison Study of Two Differently Clicked 18F-Folates—Lipophilicity Plays a Key Role

2018

Within the last decade, several folate-based radiopharmaceuticals for Single Photon Emission Computed Tomography (SPECT) and Positron Emission Tomography (PET) have been evaluated; however, there is still a lack of suitable 18F-folates for clinical PET imaging. Herein, we report the synthesis and evaluation of two novel 18F-folates employing strain-promoted and copper-catalyzed click chemistry. Furthermore, the influence of both click-methods on lipophilicity and pharmacokinetics of the 18F-folates was investigated. 18F-Ala-folate and 18F-DBCO-folate were both stable in human serum albumin. In vitro studies proved their high affinity to the folate receptor (FR). The lipophilic character of …

NO donors. Part 16: investigations on structure-activity relationships of organic mononitrates reveal 2-nitrooxyethylammoniumnitrate as a high potent…

2007

The vasoactive properties of 14 organic mononitrates were investigated in vitro using PGF(2alpha)-precontracted porcine pulmonary arteries. A surprisingly wide range of vasorelaxant potencies was observed (pD(2): 3.36-7.50). Activities showed to be highly sensitive to the molecular structure and the substituents at the molecular carrier of the nitrate group. A correlation between lipophilicity and vasorelaxant potency could not be recognized. 2-Nitrooxyethylammoniumnitrate (1) was found to be slightly superior to the high potency trinitrate GTN.

The evolution of Military Health in Valencia during the Spanish Civil War (1936-1939)

2011

Antecedentes y objetivos: Tras la insurrección militar del 18 de julio de 1936 el Ejército de la República quedó parcialmente desarticulado, resultando afectada la Sanidad Militar. En el caso de Valencia, ésta fue asumida rápidamente por el Comité Sanitario Popular, un organismo revolucionario que lideró la respuesta sanitaria de Valencia a la Guerra Civil. Posteriormente, el Gobierno Republicano procedió a recuperar el poder a través de medidas de carácter centralizador, como fue la militarización de algunos hospitales. Fue entonces cuando volvió a articularse una auténtica Sanidad Militar. El objetivo de este trabajo es estudiar la evolución de la Sanidad Militar en Valencia, una de las z…

Bloque detector PET basado en cristales monolíticos y fotomultiplicadores de silicio

2017

La tomografía por emisión de positrones (PET) es una técnica de imagen médica, encuadrada en la medicina nuclear, consistente en la generación de imágenes a partir de la detección de radiación gamma resultante de la aniquilación de positrones, emitidos por un radiotrazador, con los electrones de tejidos circundantes. Las imágenes PET son de tipo funcional, lo que permite la observación y estudio de procesos fisiológicos, sin embargo, se ha probado que la integración de estos escáneres con otros sistemas de imagen médica que proporcionen imágenes de carácter anatómico mejora notablemente las prestaciones clínicas de ambos equipos. Este tipo de equipos multimodales se conocen como sistemas hí…

VALUTAZIONE DELL' EFFICACIA DI DERIVATI ANFIFILICI DEL PEG COME " SURFACE MODIFIERS" DI NANOCARRIER DI FARMACI

2011

Enhancing effect of alpha-hydroxyacids on "in vitro" permeation across the human skin of compounds with different lipophilicity.

2005

The percutaneous penetration-enhancing effects of glycolic acid, lactic acid and sodium lauryl sulphate through the human epidermis was investigated using 5-fluorouracil as a hydrophilic model permeant and three compounds belonging to the phenylalcohols: 2-phenyl-ethanol, 4-phenyl-butanol and 5-phenyl-pentanol. The lipophilicity values of the compounds ranged from log Poct -0.95 to 2.89. The effect of the enhancer concentration was also studied. Skin pretreatment with aqueous solutions of the three enhancers did not increase the permeability coefficient of the most lipophilic compound (log Poct = 2.89). For the other compounds assayed, the increase in the permeability coefficients depended …

Measuring the Relative Reactivity of the Carbon-Hydrogen Bonds of Alkanes as Nucleophiles

2018

We report quantitative measurements of the relative reactivities of a series of C-H bonds of gaseous or liquid CnH2n+2 alkanes (n = 1-8, 29 different C-H bonds) towards insitu generated electrophiles (copper, silver, and rhodium carbenes), with methane as the reference. This strategy surpasses the drawback of previous model reactions of alkanes with strong electrophiles suffering from C-C cleavage processes, which precluded direct comparison of the relative reactivities of alkane C-H bonds.

The Relevance of Mineral Mobilization and -Dissolution on the Reservoir Quality of Sandstones in CO2 Storage Sites

2014

Abstract Rotliegend siliciclastic formations are important reservoirs in central Europe. These sediments consist of pristine red coloured and bleached, high porous and permeable sandstones. To evaluate the relevance of distinct fluids and their fluid-rock alteration reactions on such bleaching processes laboratory static batch experiments under reservoir conditions were conducted. Thereby mineralogical, petrophysical and (hydro-, geo-) chemical rock features were investigated by different analytical methods before and after the experiments. The achieved results suggest that during such fluid-rock interactions a complex interplay between mineral detachment and mineral dissolution processes w…

Synthesis and evaluation of 18F-fluoroethylated benzothiazole derivatives for in vivo imaging of amyloid plaques in Alzheimer's disease

2010

Amyloid aggregates play a major role in the development of Alzheimer's disease. Targeting these aggregates by PET probes enables non-invasively the detection and quantification of amyloid deposit distribution in human brains. Based on benzothiazole core structure a series of amyloid imaging agents were developed. Currently [(11)C]2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole (Pittsburgh Compound-B (PIB) is the most specific and widely used amyloid imaging ligand. But due to the short half life of (11)C, longer lived (18)F-labeled derivatives offer logistic advantages and higher contrast images. In this work, three different [(18)F]fluoroethoxy-substituted benzothiazole derivatives ([(18…