Search results for "Imidazoli"
showing 10 items of 173 documents
Inhibition of imidazolidinone intermediate formation in the aldol reactions catalyzed by zinc–prolinamide complexes
2011
Abstract The use of zinc salts as cocatalysts in aldol condensations catalyzed by single prolinamide (and in the extension by other more complex prolinamides) can prevent the formation of the parasitic intermediate imidazolidinone, with faster and also more stereoselective reactions than those catalyzed by the free amine. This new finding, together with this ion’s already known properties, make zinc salts highly suitable additives for aldol reactions catalyzed for prolinamide derivatives.
DESIGN OF NOVEL IMIDAZOLIUM BASED NANOSTRUCTURES FOR SUSTAINABLE CATALYTIC APPLICATIONS
New “AIE” Luminogens based on π-conjugated imidazolium salts
Molecular modeling approaches in the discovery of new drugs for anti-cancer therapy: the investigation of p53-MDM2 interaction and its inhibition by …
2010
The mdm2 oncogene product, MDM2, is an ubiquitin protein ligase that inhibits the transcriptional activity of the tumor suppressor p53 and promotes its degradation. About 50% of all human cancers present mutations or deletions in the TP53 gene. In the remaining half of all human neoplasias that express the wild-type protein, aberrations of p53 regula- tors, such as MDM2, account for p53 inhibition. For this reason, designing small-molecule inhibitors of the p53-MDM2 protein-protein interaction is a promising strategy for the treatment of cancers retaining wild-type p53. The development of inhibitors has been challenging. Although many small-molecule MDM2 inhibitors have shown potent in vitr…
Flow-cytometric screening for the modulation of receptor-mediated endocytosis in human dendritic cells: implications for the development of an in vit…
1997
The aim of this study was to explore the usefulness of human blood dendritic cells (DC) in the development of an in vitro model for predictive testing of contact sensitizers. A method was established to monitor the influence of chemicals on the intracellular targeting of antibody-crosslinked MHC class II molecules after their uptake by human DC. Using a three-colour flow-cytometric technique, freshly prepared DC were distinguished from other MHC class II-bearing cell types such as B-cells and monocytes in unseparated mononuclear cell suspensions of healthy volunteers. The assay is based on the pH-sensitivity of internalized fluorescein-coupled MHC class II specific antibodies. Quenching of …
Covalently Supported Imidazolium Salts In Catalysis
2020
Synthesis and catalytic applications of supported imidazolium salts covalently linked to the proper support are described. As supports here we report, among others, the use of amorphous and mesoporous silica, polyhedral oligomeric silsesquioxanes, magnetic-based silica, polystyrenes, halloysite nanotubes, carbon nanoforms such as fullerenes, carbon nanotubes, carbon nanohorns, graphene. The catalytic applications have been divided into two main sections, metal-free based and metal-based reactions.
Mesoscopic structural organization in triphilic room temperature ionic liquids
2013
Room temperature ionic liquids are one of the most exciting classes of materials in the last decade. The interest for these low melting, ionic compounds stems from both their technological impact and the stimulating plethora of structural and dynamic peculiarities in the mesoscopic space-time scales. It is nowadays well-established that they are characterised by an enhanced degree of mesoscopic order originating from their inherent amphiphilicity. In this contribution we highlight the existence of a further degree of mesoscopic complexity when dealing with RTILs bearing a medium length fluorous tail: such triphilic materials (they simultaneously contain polar, hydrophobic and fluorophilic m…
Knēvenāgela kondensācijas kinētika jonu šķidrumos
2015
Knēvenāgela kondensācijas kinētika jonu šķidrumos. Ūdris N., zinātniskā vadītāja Mag. ķīm. Priede E. Kursa darbs 20 lappuses, 6 attēli, 5 tabulas, 12 literatūras avoti. Latviešu valodā. Darbā veikta četru jonu šķidrumu sintēze un attīrīšana, izmantojot dažādas metodes. Visiem sintezētajiem jonu šķidrumiem tika veikti Knēvenāgela kondensācijas kinētikas pētījumi, izmantojot jonu šķidrumu kā reakcijas vidi. Visiem jonu šķidrumam tika noteikta reakcijas ātruma konstante.
para-Metoksibenzaldehīda kondensācija ar etilcianoacetātu jonu šķidrumu vidēs
2017
para-Metoksibenzaldehīda kondensācija ar etilcianoacetātu jonu šķidrumu vidēs. Freimane L., darba vadītājs Dr.h.ķīm., prof. Zicmanis A. Bakalaura darbs, 57 lappuses, 14 attēli, 8 tabulas, 42 literatūras avoti, 22 pielikumi. Latviešu valodā. Bakalaura darba literatūras apskata daļā ietverta vispārīga informācija par jonu šķidrumiem, to iegūšanu, uzbūvi un īpašībām, kā arī izmantošanas iespējām Knēvenāgela kondensācijas reakcijās. Laboratorijā tika sintezēti strukturāli atšķirīgi imidazolija rindas jonu šķidrumi, lietojot dažādas metodes. Iegūto savienojumu struktūra raksturota, izmantojot 1H KMR spektrometrijas metodi. Sintezētajos jonu šķidrumos veikta Knēvenāgela kondensācijas reakcija. No…
2,3-Difenilpropēnnitrila sintēze jonu šķidrumu vidēs
2017
2,3-Difenilpropēnnitrila sintēze jonu šķidrumu vidēs. Maševska Z., zinātniskais vadītājs prof., Dr.h.ķīm. Zicmanis A. Bakalaura darbs, 40 lappuses, 10 attēli, 14 tabulas, 35 literatūras avoti, 14 pielikumi. Latviešu valodā. Darbā apkopota literatūra par Knēvenāgela kondensācijas reakcijas principiem, jonu šķidrumu iegūšanas metodēm, to fizikāli-ķīmiskajām īpašībām. Atrasta informācija par Knēvenāgela kondensācijas reakciju norisi jonu šķidrumu vidēs. Praktiski tika sintezēti 14 dažādi bāziskie jonu šķidrumi, kas savā starpā atšķiras ar struktūras elementiem. To identitāte un tīrība tika pierādīta ar 1H KMR spektriem. Tika veikta 2,3-difenilpropēnnitrila sintēze iegūto bāzisko jonu šķidrumu …