Search results for "Immediate"

Transactivation of cellular genes involved in nucleotide metabolism by the regulatory IE1 protein of murine cytomegalovirus is not critical for viral…

2008

ABSTRACT Despite its high coding capacity, murine CMV (mCMV) does not encode functional enzymes for nucleotide biosynthesis. It thus depends on cellular enzymes, such as ribonucleotide reductase (RNR) and thymidylate synthase (TS), to be supplied with deoxynucleoside triphosphates (dNTPs) for its DNA replication. Viral transactivation of these cellular genes in quiescent cells of host tissues is therefore a parameter of viral fitness relevant to pathogenicity. Previous work has shown that the IE1, but not the IE3, protein of mCMV transactivates RNR and TS gene promoters and has revealed an in vivo attenuation of the mutant virus mCMV-ΔIE1. It was attractive to propose the hypothesis that la…

Involvement of KSRP in the post-transcriptional regulation of human iNOS expression–complex interplay of KSRP with TTP and HuR

2005

We purified the KH-type splicing regulatory protein (KSRP) as a protein interacting with the 3'-untranslated region (3'-UTR) of the human inducible nitric oxide (iNOS) mRNA. Immunodepletion of KSRP enhanced iNOS 3'-UTR RNA stability in in vitro-degradation assays. In DLD-1 cells overexpressing KSRP cytokine-induced iNOS expression was markedly reduced. In accordance, downregulation of KSRP expression increases iNOS expression by stabilizing iNOS mRNA. Co-immunoprecipitations showed interaction of KSRP with the exosome and tristetraprolin (TTP). To analyze the role of KSRP binding to the 3'-UTR we studied iNOS expression in DLD-1 cells overexpressing a non-binding mutant of KSRP. In these ce…

Avoidance and contextual learning induced by a kairomone, a pheromone and a common odorant in female CD1 mice

2015

Copyright © 2015 Fortes-Marco, Lanuza, Martínez-García and Agustín-Pavón.

A 10-Year Cone Beam Computerized Tomography Observation of the Buccal Bony Wall of an Immediately Placed Implant at the Anterior Maxilla: A Case Repo…

2017

Since the introduction of immediate implant placements, the buccal bony wall has been a major consideration for success due to its correlation with soft tissue contour and color. This report presents the stability of the buccal wall thickness of an immediately placed implant at the anterior maxilla over 10 years. Although the width of the buccal wall decreased at the 2-year post-op follow-up, it remained stable afterward according to cone beam computerized tomography (CBCT) scans. Hence, this report suggests that ensuring adequate bony wall thickness with bone augmentation and fixture position may promise the longevity of the buccal bony wall and surrounding soft tissue in an immediate impl…

Forgetting in immediate serial recall: time vs. interference. When the encoding rates determine the winner

2009

Immediate provisionalization of Astra Tech implants in healed and extraction sites: 1 to 11‐year results

2020

Diagnosis and Planning in Immediate Loading: Implant Selection

2019

Despite the increasing patients’ desire for immediate prosthetic loading of implants, several factors must be taken into account before pursuing the immediate loading (IL) protocol. In general, the number, size, characterization, and distribution of implants should be based on the implant-prosthodontic plan, arch form, and available bone quality and quantity, regardless of the loading protocol. However, implant selection in IL represents one of the most important clinical challenges due to the primary stability requirement.

Sensitivity and Specificity of Stability Criteria for Immediately Loaded Splinted Maxillary Implants

2014

Background To assess the suitability of dental implants for immediate loading, primary stability is usually evaluated intraoperatively. Purpose This retrospective study aimed to assess the suitability of three stability parameters – namely, insertion torque (IT), implant stability quotient (ISQ; measured by resonance frequency analysis), and Periotest (PT) values – as potential predictors for the risk of nonosseointegration of immediately loaded splinted implants. The stability parameters were routinely collected under immediate loading. Materials and Methods Nineteen patients with 11 edentulous and 8 partially edentulous maxillae were treated with 105 dental implants, which were immediatel…

Evaluación de 80 implantes, sometidos a carga inmediata en desdentados inferiores tras un seguimiento de dos años

2006

Objetivo: Analizar el comportamiento tanto clínico como radiológico de ochentas implantes con una nueva superficie tratada mediante una disolución de ácido sulfúrico y fluorhídrico con posterior tratamiento térmico, que han sido sometidos a carga inmediata en pacientes rehabilitados con sobredentaduras inferiores. Diseño del artículo: Estudio observacional, prospectivo en 20 pacientes rehabilitados con sobredentaduras inferiores, soportadas sobre cuatro implantes de 13 milímetros de longitud. Todos los pacientes fueron planificados e incluídos tras el consentimiento, anamnesis, exploración clínica y estudio radiográfico y mediante montaje clínico previo de la prótesis inferior. Resultados: …

Role for Chromatin Remodeling Factor Chd1 in Learning and Memory

2019

Precise temporal and spatial regulation of gene expression in the brain is a prerequisite for cognitive processes such as learning and memory. Epigenetic mechanisms that modulate the chromatin structure have emerged as important regulators in this context. While posttranslational modification of histones or the modification of DNA bases have been examined in detail in many studies, the role of ATP-dependent chromatin remodeling factors (ChRFs) in learning- and memory-associated gene regulation has largely remained obscure. Here we present data that implicate the highly conserved chromatin assembly and remodeling factor Chd1 in memory formation and the control of immediate early gene (IEG) r…