Search results for "Immunizations"

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Retinal ganglion cell loss is accompanied by antibody depositions and increased levels of microglia after immunization with retinal antigens.

2012

BackgroundAntibodies against retinal and optic nerve antigens are detectable in glaucoma patients. Recent studies using a model of experimental autoimmune glaucoma demonstrated that immunization with certain ocular antigens causes an immun-mediated retinal ganglion cell loss in rats.Methodology/principal findingsRats immunized with a retinal ganglion cell layer homogenate (RGA) had a reduced retinal ganglion cell density on retinal flatmounts (p = 0.007) and a lower number of Brn3(+) retinal ganglion cells (p = 0.0001) after six weeks. The autoreactive antibody development against retina and optic nerve was examined throughout the study. The levels of autoreactive antibodies continuously in…

MaleRetinal Ganglion Cellsgenetic structuresGlaucomaAutoimmunityImmune PrivilegeAutoantigenschemistry.chemical_compoundNeurobiology of Disease and RegenerationImmune ResponseMultidisciplinaryCell DeathMicrogliaQRAnimal ModelsImmunizationsmedicine.anatomical_structureNeurologyRetinal ganglion cellOptic nerveMedicineMicrogliaImmunohistochemical AnalysisResearch ArticleHistologyImmune CellsScienceImmunologyImmunoglobulinsModel OrganismsAntigenmedicineAnimalsAntibody-Producing CellsBiologyAutoantibodiesRetinabusiness.industryImmunityAutoantibodyGlaucomaRetinalbiochemical phenomena metabolism and nutritionmedicine.diseaseeye diseasesRatsOphthalmologychemistryRats Inbred LewImmunologyImmunologic TechniquesNeuro-OphthalmologyRatClinical ImmunologyImmunizationsense organsbusinessNeurosciencePLoS ONE

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