Search results for "Immunologia"
showing 6 items of 16 documents
Borrelia burgdorferi Outer Membrane Vesicles Contain Antigenic Proteins, but Do Not Induce Cell Death in Human Cells
2022
Like many bacterial species, Borrelia burgdorferi, the pleomorphic bacterium that causes Lyme borreliosis, produces outer membrane vesicles (OMVs). Borrelial OMVs (BbOMVs) have been identified as containing virulence factors, such as outer surface proteins (Osps) A, B, and C, as well as DNA. However, the pathogenicity of BbOMVs in disease development is still unclear. In this study, we characterized purified BbOMVs by analyzing their size and immunolabeling for known antigenic markers: OspA, OspC, p39, and peptidoglycan. In addition, BbOMVs were cocultured with human non-immune cells for cytotoxicity analysis. The results demonstrated that, on average, the vesicles were small, ranging betwe…
Immune system adaptations during competition period in female cross-country skiers
2011
Stenholm, Johanna. Immune system adaptations during competition period in female cross-country skiers. Master’s Thesis in Exercise Physiology, Department of Biology of Physical Activity. University of Jyväskylä. 95pp. Purpose. This study was undertaken to characterize the extent of immune and endocrine changes in competition period and related to two competition weekends in well trained athletes in different parts of the competition period. An additional purpose was to evaluate if the changes in immunological variables would have an effect on the incidence of upper-respiratory-tract infections. The effect of the nutrition, nutrient and training status was also studied. Methods. Ten (10) nat…
Metsäsaarekkeen koon vaikutukset puukiipijän (Certhia familiaris) lisääntymismenestykseen ja optimaaliseen pesyekokoon
2003
Kestävyysharjoittelujakson vaikutukset syljen immunologisiin muuttujiin ja sairastuvuuteen
2014
Johdanto. Ylähengitystieinfektiot ovat yleisesti tunnettu ongelma niin urheilijoiden, kuin myös kuntoilijoiden keskuudessa. Etenkin kilpaurheilijoille terveenä pysyminen on erittäin tärkeää, jotta vältytään harjoittelua ja kilpailemista haittaavilta sairauspäiviltä. Kuitenkin urheilijat näyttävät olevan alttiimpia hengitystieinfektioille ja tutkimusten perusteella kurkkukipu sekä flunssan kaltaiset oireet ovat yleisempiä ja pitkäkestoisempia kuin muulla väestöllä. Tämän tutkimuksen tarkoituksena oli selvittää kestävyysjuoksuharjoittelun vaikutuksia syljen immunologisiin muuttujiin, lyhytaikaisiin vasteisiin maksimaalisessa hapenottotestissä sekä ylähengitystieinfektioiden esiintyvyyteen. Me…
Ruolo dei linfociti citotossici T CD8+ HLA-E ristretti in risposta ad epitopi di Mycobacterium tuberculosis veicolati tramite un tossoide ricombinant…
2023
Pathogenic mechanisms of how human parvovirus breaks self-tolerance
2017
It is known that viral infections can cause acute, chronic, and autoimmune diseases (ADs). However, the mechanism of how a persistent viral infection contributes to ADs remains still unclear. In this thesis, pathological and immunological aspects of how common viruses can initiate autoimmunity were investigated, and human parvovirus B19 (B19V) was employed as a model virus. B19V non-structural protein 1 (NS1), a superfamily 3 (SF3) helicase, initiated DNA damage resulting in cellular apoptosis. The apoptotic bodies (ApoBods) induced by B19V NS1 were purified and characterized. These ApoBods contained viral NS1 proteins with modified autoimmune-associated self-antigens, e.g. DNA, Smith, Apol…