Search results for "Import"
showing 10 items of 286 documents
El ajuste de las características del trabajo como indicador de calidad del trabajo
2017
La calidad del trabajo es un fenómeno complejo que es de interés tanto para la academia, como para los profesionales en RRHH y organismos internacionales. Sin embargo, hoy día no hay consenso sobre las características que deberían integrar este fenómeno, ya que dependiendo del marco conceptual desde el cual se esté trabajando, se pueden incluir unas características y excluir otras. Desde la psicología del trabajo y las organizaciones, el estudio de la calidad del trabajo se ha enfocado en las características del trabajo en sí, es decir las actividades laborales que se realizan durante la jornada de trabajo y el contexto que rodea a dichas actividades. Para investigar estas características, …
Cytoplasmic Parvovirus Capsids Recruit Importin Beta for Nuclear Delivery
2019
Parvoviruses are an important platform for gene and cancer therapy. Their cell entry and the following steps, including nuclear import, are inefficient, limiting their use in therapeutic applications. Two models exist on parvoviral nuclear entry: the classical import of the viral capsid using nuclear transport receptors of the importin (karyopherin) family or the direct attachment of the capsid to the nuclear pore complex leading to the local disintegration of the nuclear envelope. Here, by laser scanning confocal microscopy and in situ proximity ligation analyses combined with coimmunoprecipitation, we show that infection requires importin β-mediated access to the nuclear pore complex and …
Tres artistas en el exilio: Max Aub, Félix Candela y Josep Renau
2020
Three artists in exile focuses on the historical diaspora provoked by the Spanish civil war (1936- 1939), and how it influenced three prominent figures of the cultural scene of that period: the writer and typographer Max Aub Mohrenwitz (Paris, 1903-Ciudad de Mexico, 1972); the architect Félix Candela Outeriño (Madrid, 1910-Raleigh, US, 1977); and the artist Josep Renau Berenguer (Valencia, 1907-Berlín, 1982). They are the three protagonists of this article, who were simultaneously living in Mexico during the exile and who made notable contributions in the fields of arts and humanities (Max Aub), architecture (Félix Candela), and graphic design and photomontage (Josep Renau). While they were…
Metodologia per l’individuazione di aree di importanza faunistica
2008
Chemical Proteomics-Guided Identification of a Novel Biological Target of the Bioactive Neolignan Magnolol
2019
Understanding the recognition process between bioactive natural products and their specific cellular receptors is of key importance in the drug discovery process. In this outline, some potential targets of Magnolol, a natural bioactive compound, have been identified by proteomic approaches. Among them, Importin-β1 has been considered as the most relevant one. A direct binding between Magnolol and this nuclear chaperone has been confirmed by DARTS and molecular docking, while its influence on Importin-β1 translocation has been evaluated by in vitro assays.
Promoter Activation in Dhfq Mutants as an Efficient Tool for Specialized Metabolite Production Enabling Direct Bioactivity Testing
2019
Abstract Natural products (NPs) from microorganisms have been important sources for discovering new therapeutic and chemical entities. While their corresponding biosynthetic gene clusters (BGCs) can be easily identified by gene‐sequence‐similarity‐based bioinformatics strategies, the actual access to these NPs for structure elucidation and bioactivity testing remains difficult. Deletion of the gene encoding the RNA chaperone, Hfq, results in strains losing the production of most NPs. By exchanging the native promoter of a desired BGC against an inducible promoter in Δhfq mutants, almost exclusive production of the corresponding NP from the targeted BGC in Photorhabdus, Xenorhabdus and Pseud…
Sport and Quality of Life
2022
Negli ultimi trent’anni lo sport ha assunto un significato molto rilevante nella vita delle persone e, seppure con notevoli differenze, sia nei paesi a sviluppo economico avanzato, sia in quelli in via di sviluppo. A livello individuale, esso ha costituito un’area di investimento identitario quando ha assunto la forma di sport spettacolo del quale fruire, alimentando la pratica del tifo e il fandom o costituendo il modello di uno stile di vita vincente; ma anche quando ha assunto la forma di pratica del tempo libero attraverso la quale tenersi in forma, facendo crescere, in questo caso, la diffusione di una cultura della salute e del benessere. Si tratta di due modalità di approcciare al co…
Importaciones de los siglos VI-V aC en el centro y norte del País Valenciano
2000
En el siguiente trabajo hacemos una aproximación a las cerámicas de filiación griega de época arcaica (siglos VI-V a.C.) llegadas a los poblados ibéricos de la zona Norte y centro del País Valenciano fruto del intercambio comercial entre indígenas y navegantes de origen griego o púnico. Quedan fuera las comarcas meridionales ya que son objeto, en esta misma reunión, de otras dos comunicaciones de esta misma reunión. This paper is an overview about all archaic imports found in north and center of Valencian country. These imports are diverse provenance and it is important to note the greek trade amphoras scarcity, placed along the coast; whereas, the phenico-punic amphoras and the greek table…
Engineered Multifunctional Nanotools for Biological Applications
2011
Smart multifunctional magnetic nanoparticles are popular candidates for several biological applications owing to their intrinsic magnetic property and diverse applications that range from rare protein separation and biomedical utilization to cancer therapy and diagnostics. A universal protocol, for the development of such nanocarriers, is highly desirable for scientists with different backgrounds so that custom-made multifunctional nanoparticles can be developed to address their needs, among which are the superparamagnetic iron oxide and manganese oxide nanoparticles that are synthesized through high temperature decomposition reactions. However, an interface is needed to present these inorg…