Search results for "InVEST"
showing 10 items of 2596 documents
Meta-action research with pre-service teachers: a case study
2014
This article analyses a case of action research collaboratively conducted by a university teacher and 50 students in a master's course in teacher training. Its originality resides in the socio-economic, academic, and conceptual nature of the obstacles encountered in the module; in the meta-theoretical orientation of the action research that was chosen to overcome them; and in how triangulation strategies were devised to compensate for the limitations imposed by the academic framing of the course. In spite of the brevity of the research cycle, both the structure of the course and teacher-student interaction improved rapidly and significantly, as did the latter's trust in the teacher. As a re…
Espacios y prácticas de participación ciudadana. Propuestas educativas desde una mirada intercultural
2018
El artículo presenta la investigación de tesis doctoral que se ha desarrollado en cuatro espacios de participación ciudadana de la ciudad de Madrid durante tres años (2015/2017). Consideramos que la ciudadanía se aprende ejerciéndola y que los espacios de participación son escuelas de ciudadanía. La finalidad del estudio es formular propuestas educativas para el aprendizaje de la ciudadanía activa a partir del análisis de lo que sucede en dichos espacios. El texto se estructura en torno a estos apartados: 1) reflexiones y premisas en relación a la participación y la educación para la ciudadanía; 2) antecedentes directos de la investigación y las continuidades que se dan en este trabajo…
Expectation Damages and Bilateral Cooperative Investments
2012
We examine the efficiency of the standard breach remedy expectation damages in a setting where the buyer invests cooperatively and the seller invests both cooperatively and selfishly. Contracts may specify a required quality level and an upper bound to the seller's coordination costs. We find that it is optimal to write an augmented Cadillac contract in which quality is stipulated such that it cannot be met with positive probability together with a very low price. Thus, the seller becomes a residual claimant and the coordination-cost threshold can be used to balance the incentives of the buyer.
Syyllisyyden kirjoittuminen rikoksesta epäillyn kuulustelukertomukseen
2020
How guilt or innocence is constructed in Finnish suspects written police records
 The present study focuses on written police records in Finland. The aim is to investigate how guilt or innocence is constructed in written police records. The research data contains 168 copy of suspects police records from Helsinki, Tampere and Turku police departments. Police records are being analyzed by using the discursive and linguistic approach. The results show that there are nine discursive categories in which guilt is constructed. The results also show that there are three types of metafunctions in which guilt is constructed: content, interaction and linguistic presentation. All them together con…
Identity and socio-educational responsibilities of the educational mediator and the intercultural mediator: towards a clarification of functions
2012
El presente artículo reconoce que, ante la creciente presencia en escenarios socioeducativos de la figura profesional del mediador en los dos ámbitos principales relacionados con la educación (el escolar y el intercultural), deben identificarse los rasgos idiosincrásicos de cada uno de ellos, lo que no es óbice para reconocer cómo, a pesar de que existen, en efecto, diferencias en la definición de estos dos modelos de mediación, se evidencian aspectos coincidentes que los vinculan a un tronco común: las competencias y responsabilidades socioeducativas que adquieren cada uno de ellos. Las autoras del artículo aplican la metodología comparada para demostrar ambas realidades compatibles en las…
Anti-endothelin drugs in solid tumors
2010
Importance of the field: The endothelin (ET) axis, which includes the biological functions of ETs and their receptors, has played a physiological role in normal tissue, acting as a modulator of vasomotor tone, tissue differentiation and development, cell proliferation and hormone production. Interestingly, it also functions in the growth and progression of various tumors. Several researchers have identified the blockade of the ET-1 receptor as a promising therapeutic approach. Areas covered in this review: The clinical investigation of an orally bioavailable ET antagonist, atrasentan, in prostate cancer, is encouraging. In this neoplasia, it has shown antitumor activity, bone metastasis con…
Phase III, Multicenter Open-Label Study to Investigate the Efficacy of Elbasvir and Grazoprevir Fixed-Dose Combination for Eight Weeks in Treatment-N…
2020
Background: Genotype 1b is the most common HCV genotype worldwide, accounting for the largest proportion of infections in Europe, Russia, Latin America and Asia. Reducing treatment duration can improve adherence, reduce drug exposure and cost. Accordingly, we evaluated the efficacy of eight weeks fixed dose combination of grazoprevir-elbasvir in treatment-naive patients, with non-severe fibrosis. Methods: HCV mono-infected and treatment naive patients with non-severe fibrosis (Fibroscan®<9·5kPa and Fibrotest®<0·59) were enrolled in a study which included 117 patients. Genotyping by sequencing identified five patients with non-1b genotype (two GT1a, one GT1h, one GT1e and one GT1l). Thus, we…
Emerging therapies for raising high-density lipoprotein cholesterol (HDL-C) and augmenting HDL particle functionality.
2014
High-density lipoprotein (HDL) particles are highly complex polymolecular aggregates capable of performing a remarkable range of atheroprotective functions. Considerable research is being performed throughout the world to develop novel pharmacologic approaches to: (1) promote apoprotein A-I and HDL particle biosynthesis; (2) augment capacity for reverse cholesterol transport so as to reduce risk for the development and progression of atherosclerotic disease; and (3) modulate the functionality of HDL particles in order to increase their capacity to antagonize oxidation, inflammation, thrombosis, endothelial dysfunction, insulin resistance, and other processes that participate in arterial wal…
The use of low level laser therapy in the treatment of temporomandibular joint disorders: review of the literature
2013
Introduction: The temporomandibular disorders (TMDs) have been identified as the most important cause of pain in the facial region. The low level laser therapy (LLLT) has demonstrated to have an analgesic, anti-inflammatory and biostimulating effects. The LLLT is a noninvasive, quick and safe, non-pharmaceutical intervention that may be beneficial for patients with TMDs. However the clinical efficiency of LLLT in the treatment of this kind of disorders is controversial. Objectives: Literature review in reference to the use of LLLT in the treatment of TMDs, considering the scientific evidence level of the published studies. Material and Methods: A MEDLINE and COCHRANE database search was mad…
Intraoperative DNA methylation classification of brain tumors impacts neurosurgical strategy
2021
Abstract Background Brain tumor surgery must balance the benefit of maximal resection against the risk of inflicting severe damage. The impact of increased resection is diagnosis-specific. However, the precise diagnosis is typically uncertain at surgery due to limitations of imaging and intraoperative histomorphological methods. Novel and accurate strategies for brain tumor classification are necessary to support personalized intraoperative neurosurgical treatment decisions. Here, we describe a fast and cost-efficient workflow for intraoperative classification of brain tumors based on DNA methylation profiles generated by low coverage nanopore sequencing and machine learning algorithms. Met…