Search results for "Inbred SHR"

showing 2 items of 42 documents

Acute and Chronic Captopril, but Not Prazosin or Nifedipine, Normalize Alterations in Adrenergic Intracellular Ca2+ Handling Observed in the Mesenter…

2004

The effect of hypertension and acute (36-h) or chronic (from age 6 to 16 weeks) antihypertensive treatment with prazosin (2 mg kg(-1) per day), nifedipine (50 mg kg(-1) per day), or captopril (50 mg kg(-1) per day) on Ca2+ mobilization due to alpha1-adrenoceptor activation was analyzed in functional studies using arterial rings [four conductance/distributing vessels: aorta, main mesenteric, iliac, and tail arteries and two resistance vessels; first and second small mesenteric artery branches obtained from spontaneously hypertensive rats (SHR, 6 and 16 weeks old) and age-matched Wistar Kyoto rats (WKY)]. Maximal response to noradrenaline in the presence of extracellular Ca2+ is not affected …

medicine.medical_specialtyCaptoprilSympathetic Nervous SystemNifedipineAdrenergicAngiotensin-Converting Enzyme InhibitorsBlood PressureRats Inbred WKYMuscle Smooth VascularNorepinephrineNifedipineRats Inbred SHRInternal medicinemedicine.arteryPrazosinAnimalsVasoconstrictor AgentsMedicineMesenteric arteriesAdrenergic alpha-AntagonistsPharmacologyAortabusiness.industryCaptoprilPrazosinCalcium Channel BlockersMesenteric ArteriesRatsEndocrinologyBlood pressuremedicine.anatomical_structurecardiovascular systemMolecular MedicineCalciumbusinessMuscle Contractionmedicine.drugArteryJournal of Pharmacology and Experimental Therapeutics
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The impact of alpha1-adrenoceptors up-regulation accompanied by the impairment of beta-adrenergic vasodilatation in hypertension

2008

9 pages, 7 figures, 3 tables.-- PMID: 19060223 [PubMed]

medicine.medical_specialtyG-Protein-Coupled Receptor Kinase 2Adrenergic receptorSystolemedia_common.quotation_subjectAdrenergicVasodilationModels BiologicalRats Inbred WKYDownregulation and upregulationHeart RateRats Inbred SHRReceptors Adrenergic alpha-1Internal medicineReceptors Adrenergic betamedicineAnimalsHumansRNA MessengerReceptorInternalizationAortamedia_commonPharmacologybiologyChemistryKinaseBeta adrenergic receptor kinaseRatsUp-RegulationVasodilationEndocrinologyHypertensionbiology.proteinMolecular Medicine
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