Search results for "Inde"

The sharedneoantigen landscape of MSI cancers reflects immunoediting during tumor evolution

2019

AbstractThe immune system can recognize and attack cancer cells, especially those with a high load of mutation-inducedneoantigens. Suchneoantigens are particularly abundant in DNA mismatch repair (MMR)-deficient, microsatellite-unstable (MSI) cancers. MMR deficiency leads to insertion/deletion (indel) mutations at coding microsatellites (cMS) and toneoantigen-inducing translational frameshifts. The abundance of mutationalneoantigens renders MSI cancers sensitive to immune checkpoint blockade. However, the neoantigen landscape of MMR-deficient cancers has not yet been systematically mapped. In the present study, we used a novel tool to monitorneoantigen-inducing indel mutations in MSI colore…

Trends in Microbiology publications: are classic scientific journals condemned to extinction?

2020

ABSTRACT Scientific journals have played an essential role in the diffusion of research breakthroughs. For many years there was no competition between journals, but, in recent decades they have become categorized by a careful assessment of their published contents based on several metric parameters. Of greater note, the ‘prestige index’ has become an essential tool used by public and private institutions to develop their scientific policy. Thus, the evaluation of research staffs, the concession of grants or fellowships and even the scholarly reputation and academic positions are mainly founded on a given journal's ‘quality’. As a consequence, the prestige of some journals has gone up, based…

Mapping effective connectivity between the frontal and contralateral primary motor cortex using dual-coil transcranial magnetic stimulation

2019

AbstractCytoarchitectonic, anatomical and electrophysiological studies have divided the frontal cortex into distinct functional subdivisions. Many of these subdivisions are anatomically connected with the contralateral primary motor cortex (M1); however, effective neurophysiological connectivity between these regions is not well defined in humans. Therefore, we aimed to use dual-coil transcranial magnetic stimulation (TMS) to map, with high spatial resolution, the effective connectivity between different frontal regions of the right hemisphere and contralateral M1 (cM1). TMS was applied over the left M1 alone (test pulse) or after a conditioning pulse was applied to different grid points co…

Psychometric Properties Of The Finnish Version Of The Locomotor Capabilities Index-5

2016

Long-term home-based physiotherapy for persons with signs of frailty–RCT (NCT02305433)

2018

Introduction/Background Frailty is a multidimensional condition, which can lead to disability. To postpone long-term care, one alternative is home-based physiotherapy. We study the effects of a 12-month home-based physiotherapy program on functional capacity, and applying successive 12-month register follow-up, on the use and costs of social and health care services, and on the duration of living at home during 24 months (the primary outcome). Here we report about feasibility of the intervention and baseline characteristics. Material and method Three hundred home-dwelling persons (>65 y) with signs of frailty were recruited by September, 2016. Frailty was screened by Morley's FRAIL question…

Effects of a home-based rehabilitation program in community-dwelling older people after discharge from hospital: A subgroup analysis of a randomized …

2021

Objective: To examine whether pre-admission community mobility explains the effects of a rehabilitation program on physical performance and activity in older adults recently discharged from hospital. Design: A secondary analysis of a randomized controlled trial. Setting: Home and community. Participants: Community-dwelling adults aged ⩾60 years recovering from a lower limb or back injury, surgery or other disorder who were randomized to a rehabilitation ( n = 59) or standard care control ( n = 58) group. They were further classified into subgroups that were not planned a priori: (1) mild, (2) moderate, or (3) severe pre-admission restrictions in community mobility. Interventions: The 6-mont…

Effectiveness of Shock Wave Therapy as a Treatment for Spasticity: A Systematic Review

2021

Background: The purpose of this study was to collect and analyse the available scientific evidence on the effectiveness of shock wave therapy as a treatment for spasticity. Methods: the search was performed in the following databases: PubMed, PEDro, Cochrane, Embase, and the Virtual Health Library. All publications from November 2009 to November 2019 were selected that included a sample of patients with spasticity and prior suspension of botulinum toxin, to whom shock wave therapy was applied. The methodological quality of the articles was evaluated using the Jadad scale and the pyramid of quality of scientific evidence. Results: 25 studies involving 866 participants with spasticity were se…

Improving Speaker-Independent Lipreading with Domain-Adversarial Training

2017

We present a Lipreading system, i.e. a speech recognition system using only visual features, which uses domain-adversarial training for speaker independence. Domain-adversarial training is integrated into the optimization of a lipreader based on a stack of feedforward and LSTM (Long Short-Term Memory) recurrent neural networks, yielding an end-to-end trainable system which only requires a very small number of frames of untranscribed target data to substantially improve the recognition accuracy on the target speaker. On pairs of different source and target speakers, we achieve a relative accuracy improvement of around 40% with only 15 to 20 seconds of untranscribed target speech data. On mul…

Trade, financial openness and dual banking economies: Evidence from GCC Region

2021

Abstract The recent wave of liberalization in Gulf Cooperation Council (GCC) countries has opened up a debate on the role of Islamic finance in the financial development of an economy. Using a comprehensive dataset of 43 Islamic and 49 conventional banks for the period 2007–2015, in this paper, we investigate the impact of trade and financial openness on financial development in the GCC region. We find that trade and financial openness have a positive effect on the profitability of both banking systems, while the interaction term of openness is negative for the profitability of Islamic banks. Moreover, trade and financial openness affect Islamic banks differently than conventional banks. No…

Evaluation of geomorphometric characteristics and soil properties after a wildfire using Sentinel-2 MSI imagery for future fire-safe forest

2021

Abstract Understanding spatiotemporal geomorphological and pedological changes as a consequence of wildfires can allow stakeholders, land planners, and policymakers to design efficient fire safety-based afforestation and restoration programs of forest lands. The use of remote sensing techniques is a key tool to achieve this goal. The suitable combination of Sentinel-2 MSI data for mapping of different spectral indices related to burn severity and their relationship with other morphometric and soil properties can contribute to a better understanding of the impact of fire, and this is relevant in regions where is still scarce fire-related research such as Turkey. In this investigation, the us…