Search results for "Indicator"

Cadherin 23 is a component of the transient lateral links in the developing hair bundles of cochlear sensory cells

2005

AbstractCadherin 23 is required for normal development of the sensory hair bundle, and recent evidence suggests it is a component of the tip links, filamentous structures thought to gate the hair cells' mechano-electrical transducer channels. Antibodies against unique peptide epitopes were used to study the properties of cadherin 23 and its spatio-temporal expression patterns in developing cochlear hair cells. In the rat, intra- and extracellular domain epitopes are readily detected in the developing hair bundle between E18 and P5, and become progressively restricted to the distal tip of the hair bundle. From P13 onwards, these epitopes are no longer detected in hair bundles, but immunoreac…

Correlation between the level of the potential biomarker, heat-shock protein, and the occurrence of DNA damage in the dab, Limanda limanda: a field s…

2000

In the present study, heat-shock protein of M-r 70 kDa (HSP70), a marker of cellular stress response, was validated as a potential biomarker under field conditions. The dab, Limanda limanda (female, size greater than or equal to 25 cm, spawning maturity stage 2) was used as the indicator organism. The data on HSP level were correlated with the occurrence of DNA damage, measured in the same specimens of L. limanda, to prove the usefulness of the method. The area under investigation was the North Sea. Four locations were selected: station N01, close to Heligoland, in the North Sea; station N04 at the Dogger Bank; station N06 at the Firth of Forth; and station G08 in the English Channel. Ten a…

Micellar electrokinetic chromatography with bile salts for predicting ecotoxicity of aromatic compounds.

2004

The retention factors of several aromatic compounds were obtained by micellar electrokinetic chromatography (MEKC) using cholate, taurocholate, deoxycholate and deoxytaurocholate as micellar systems. The possibility of using these retention factors to describe and predict several ecotoxicological activities of different aromatic compounds was evaluated. Adequate correlations retention–ecotoxicity (log LC50 in fish and daphnia, log EC50 in green algae and daphnia, chronic values in fish and green algae, bioconcentration factor, and soil sorption coefficient) were obtained for the micellar systems studied. The predictive ability of the models obtained for these micellar systems was compared. …

IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 4: Prediction accuracy and software comparisons with…

2020

Oral drug absorption is a complex process depending on many factors, including the physicochemical properties of the drug, formulation characteristics and their interplay with gastrointestinal physiology and biology. Physiological-based pharmacokinetic (PBPK) models integrate all available information on gastro-intestinal system with drug and formulation data to predict oral drug absorption. The latter together with in vitro-in vivo extrapolation and other preclinical data on drug disposition can be used to predict plasma concentration-time profiles in silico. Despite recent successes of PBPK in many areas of drug development, an improvement in their utility for evaluating oral absorption i…

A low level image analysis approach to starfish detection

2003

Single imputation method of missing values in environmental pollution data sets

2006

Abstract Missing data represent a general problem in many scientific fields above all in environmental research. Several methods have been proposed in literature for handling missing data and the choice of an appropriate method depends, among others, on the missing data pattern and on the missing-data mechanism. One approach to the problem is to impute them to yield a complete data set. The goal of this paper is to propose a new single imputation method and to compare its performance to other single and multiple imputation methods known in literature. Considering a data set of PM 10 concentration measured every 2 h by eight monitoring stations distributed over the metropolitan area of Paler…

A Little Bird Told Me: Discovering KPIs from Twitter Data

2020

The goal of our research and experiments is to find the definitions and values of key performance indicators (KPIs) in unstructured text. The direct access to opinions of customers served as a motivating factor for us to choose Twitter data for our experiments. For our case study, we have chosen the restaurant business domain. As in the other business domains, KPIs often serve as a solution for identification of current problems. Therefore, it is essential to learn which criteria are important to restaurant guests. The mission of our Proof-of-Concept KPI discovery tool presented in this paper is to facilitate the explorative analysis taking Twitter user posts as a data source. After process…

Extending a Metamodel for Formalization of Data Warehouse Requirements

2014

In performance measurement systems that are built on top of a data warehouse, the information requirements in natural language are different performance indicators that should be stored and analyzed. We use the requirement formalization metamodel to create a formal requirement repository out of information requirements in natural language. In the course of this research we tested the compatibility of the existing requirement formalization metamodel applying it to a set of over 150 requirements for the currently operating data warehouse project. As a result, we extended the formal specification of information requirements with some additional classes like themes, grouping, and requirement pr…

Presentation and analysis of an original database of the institutional characteristics of developing, in transition and developed countries

2004

The disparity between the development paths followed by the economies of a limited number of countries, known as ‘emerging’, and the bulk of the other developing countries has shown the limitations of previous development strategies. As a consequence, at the beginning of the 1990s, the question of institutions has been propelled to the top of the economic agenda. Theempirical literature has now solidly documented and validated the general relationship between institutions and development. With this as a starting point, attention is now being concentrated on the actual nature of theinstitutional mechanisms at work, the inter-relationships between them and their combined impact on development…

Energy saving in wastewater treatment plants: A plant-generic cooperative decision support system

2017

Abstract In Europe, the analysis of Waste Water Treatment Plants (WWTPs) shows a significant energy efficiency potential (up to 25%). Optimistically, plant managers assess their plant efficiency once or twice per year. Consequently, the time gap between an inefficiency and its detection produces avoidable operational costs. Although the installation of multiple on-line sensors can provide detailed energy information, for a human operator it is unrealistic to analyse the produced data in a satisfactory time-scale. This paper proposes a cooperative tool for energy saving that remotely accesses and evaluates WWTP databases to produce daily energy assessment reports. The novelty of this decisio…