Search results for "Infiltration"

Maximizing the Extent of Resection in High-Grade Glioma.

2019

High-grade gliomas (HGGs) are devastating tumors associated with one of the worst prognoses in oncology. Glioblastoma multiforme (GBM) is the most frequently reported histologic type, with a median survival after surgery and combined treatment with chemotherapy and radiotherapy of 12–16 months. Several studies have shown that the extent of resection (EOR) of the contrast-enhancing part of the tumor improves survival in patients with HGGs, although the quest to achieve optimal oncologic outcomes must be tempered with the neurologic result following radical resection. To date, limited evidence exists on the relationship between EOR and level of clinical benefit for patients with HGGs. Brown e…

Liver vein infiltration in patients with hepatocellular carcinoma in a large German cohort

2018

Giant cell granuloma of the maxilla. Global management, review of literature and case report.

2012

Giant cell granuloma is a relatively rare benign entity but can be locally aggressive. Histologically characterized by intense proliferation of multinucleated giant cells and fibroblasts. Affects bone supported tissues. Definitive diagnosis is given by biopsy. Clinically manifest as a mass or nodule of reddish color and fleshy, occasionally ulcerated surface. They can range from asymptomatic to destructive lesions that grow quickly. It is a lesion to be considered in the differential diagnosis of osteolytic lesions affecting the maxilla or jaw. Its management passed from conservative treatment with intralesional infiltration of corticosteroids, calcitonin or interferon, to the surgical rese…

Comparison of Procedures to estimate Steady Flow Rate in Field Measurement of Saturated Hydraulic Conductivity by the Guelph Permeameter Method

1999

Abstract Different procedures for estimating steady flow rate during field application of the Guelph permeameter method were compared in terms of field-saturated hydraulic conductivity K fs and equilibration time t s estimates. The steady flow rate was evaluated by the slope of the linear portion of the cumulative drop in water level in the permeameter reservoir versus time plot (reference procedure) and by approximate procedures that use the first three or four consecutive values of the rate of fall of the water level equal or differing by less than a given percentage. The influence of the selected time interval between two successive readings ( Δt =2 or 10 min) at the permeameter was also…

Sodium/hydrogen exchange inhibition with cariporide reduces leukocyte adhesion via P-selectin suppression during inflammation

2008

Background and purpose: The Na+/H+ exchange (NHE) inhibitor cariporide is known to ameliorate ischaemia/reperfusion (I/R) injury by reduction of cytosolic Ca2+ overload. Leukocyte activation and infiltration also mediates I/R injury but whether cariporide reduces I/R injury by affecting leukocyte activation is unknown. We studied the effect of cariporide on thrombin and I/R induced leukocyte activation and infiltration models and examined P-selectin expression as a potential mechanism for any identified effects. Experimental approach: An in vivo rat mesenteric microcirculation microscopy model was used with stimulation by thrombin (0.5 μ ml−1) superfusion or ischaemia (by haemorrhagic shock…

Comparison of unconfined and confined unsaturated hydraulic conductivity

2007

Abstract The field tension infiltrometer (TI) and the laboratory unit hydraulic gradient (UHG) methods are widely applied to determine the near-saturated soil hydraulic conductivity, K . Comparison between the two methods is relevant given that they differ in the explored soil volume (undetached or detached) and in the flow process (unconfined or confined). The objective of this investigation was to compare unconfined and confined measurements of unsaturated hydraulic conductivity. Twenty TI experiments were conducted in a relatively coarse-textured soil having an appreciable hysteretic behavior by using two different dry-to-wet-to-dry (DTWTD) sequences of pressure head, h 0 , values that d…

Natural Products as Modulators of Apoptosis and their Role in Inflammation

2006

ABSTRACT: Modifications in apoptosis, a programmed form of cell death that participates in a wide variety of physiological processes, can contribute to many diseases, principally those associated with cell accumulation, such as inflammation. One hallmark of inflammation is the infiltration of leukocytes, which are programmed to undergo apoptosis at inflamed tissues. Resolution of inflammation thus involves the elimination of excess inflammatory cells by physiological cell death and the subsequent removal of apoptotic cells by phagocytes. Controlling this process may therefore be useful in the treatment of pathologies, which include an inflammatory component. Interestingly, while in some cas…

Chronic obstructive pulmonary disease and neutrophil infiltration: role of cigarette smoke and cyclooxygenase products.

2010

Cigarette smoke is the main cause of chronic obstructive pulmonary disease (COPD), where it can contribute to the observed airway inflammation. PGE(2) is produced within human airways, and both pro- and anti-inflammatory activities have been reported. We quantitated PGE(2) concentrations in induced sputum supernatants from different groups of subjects and correlated the obtained values to neutrophil infiltration as well as to the expression of cyclooxygenase-2 (COX-2). Cigarette smoke extract (CSE) was used to evaluate the effect of smoking on COX-2 and PGE(2) receptor expression as well as on PGE(2) release in neutrophils and alveolar macrophages (AM) obtained from normal donors. The effec…

Divergent effects of biolistic gene transfer in a mouse model of allergic airway inflammation.

2007

Particle-mediated epidermal delivery (PMED) of allergen genes efficiently prevents systemic sensitization and suppresses specific immunoglobulin E synthesis. We investigated in a mouse model of allergic airway disease the effect of PMED on the elicitation of local inflammatory reactions in the lung. BALB/c mice were biolistically transfected with plasmids encoding beta-galactosidase (betaGal) as model allergen under control of the DC-targeting fascin promoter and the ubiquitously active cytomegalovirus promoter, respectively. Mice were challenged intranasally with betaGal-protein with or without intermediate sensitization with betaGal adsorbed to aluminiumhydroxide. Subsequently, local cyto…

Urban Storm-Water Quality Management: Centralized versus Source Control

2010

The continuous growth of urban areas and the increasing public awareness of the environmental impacts of storm water have raised interest on the quality of the receiving water bodies. In the past two decades, many efforts have been directed at improving urban drainage systems by introducing mitigation measures to limit the negative environmental impacts of storm water. These mitigation measures are generally called best management practices (BMPs), sustainable urban drainage systems, or low impact developments, and they include practices such as infiltration and storage tanks that reduce the peak flow and retain some of the polluting materials. Choosing the best mitigation measure is still …