Search results for "Inflammaging"
showing 7 items of 17 documents
Cellular Senescence in Age-Related Diseases: Molecular Bases and Therapeutic Interventions
2022
Due to the increase in life expectancy, the aging population around the globe has been growing significantly and is estimated to triple by 2050 [...]
Aging and chronic inflammation: highlights from a multidisciplinary workshop
2023
Abstract: Aging is a gradual, continuous series of natural changes in biological, physiological, immunological, environmental, psychological, behavioral, and social processes. Aging entails changes in the immune system characterized by a decrease in thymic output of naïve lymphocytes, an accumulated chronic antigenic stress notably caused by chronic infections such as cytomegalovirus (CMV), and immune cell senescence with acquisition of an inflammatory senescence-associated secretory phenotype (SASP). For this reason, and due to the SASP originating from other tissues, aging is commonly accompanied by low-grade chronic inflammation, termed “inflammaging”. After decades of accumulating evide…
Immunity and Aging
2016
In the elderly, many alterations of innate and acquired immunity have been described and viewed as deleterious, hence the term immunosenescence. Immunosenescence is a complex process involving multiple reorganizational and developmentally regulated changes, rather than simple unidirectional decline of complete immune function. On the other hand, some immunological parameters are commonly notably reduced in the elderly, and reciprocally good function is tightly correlated to health status. Whereas innate immunity is relatively well preserved in elderly, acquired immunity is more susceptible due to both the functional decline associated with the passage of time, and to antigen burden to which…
Effects of Oleuropein and Hydroxytyrosol on Inflammatory Mediators: Consequences on Inflammaging
2022
Aging is associated with a low-grade, systemic inflammatory state defined as “inflammaging”, ruled by the loss of proper regulation of the immune system leading to the accumulation of pro-inflammatory mediators. Such a condition is closely connected to an increased risk of developing chronic diseases. A number of studies demonstrate that olive oil phenolic compound oleuropein and its derivative hydroxytyrosol contribute to modulating tissue inflammation and oxidative stress, thus becoming attractive potential candidates to be used in the context of nutraceutical interventions, in order to ameliorate systemic inflammation in aging subjects. In this review, we aim to summarize the available d…
Anti-Inflammatory Effects of Nutritionally Relevant Concentrations of Oleuropein and Hydroxytyrosol on Peripheral Blood Mononuclear Cells: An Age-Rel…
2023
: Immunosenescence and inflammaging facilitate the insurgence of chronic diseases. The Mediterranean diet is a non-invasive intervention to improve the chronic low-grade inflammatory status associated with aging. Olive oil oleuropein (OLE) and hydroxytyrosol (HT) demonstrated a controversial modulatory action on inflammation in vitro when tested at concentrations exceeding those detectable in human plasma. We studied the potential anti-inflammatory effects of OLE and HT at nutritionally relevant concentrations on peripheral blood mononuclear cells (PBMCs) as regards cell viability, frequency of leukocyte subsets, and cytokine release, performing an age-focused analysis on two groups of subj…
LONGEVITY AND THE SECRETS OF CENTENARIANS
2017
Aging of the world populations represents one of the most remarkable success stories of medicine and of humankind. Hence, the search for ways to prolong health expectancy is a primary goal in medicine. Human life expectancy increased extraordinarily during the last century worldwide. Life expectancy at birth has almost doubled in most developed countries over the last century, with the oldest group being the most rapidly growing segment of the population. The number of centenarians in Italy is over 16.000 and the number is over tripled in few years (they were 5.000 in 2001). Among older population, centenarians may be considered the best example of successful aging. The capacity to avoid, d…
Valoración de parámetros celulares y bioquímicos como marcadores de inmunosenescencia y su relación con variables clínicas en pacientes con cáncer de…
2022
Los cambios que se producen en el sistema inmune con la edad son poco conocidos en los pacientes con cáncer de pulmón no microcítico (CPNM) y esto es clave para realizar un uso óptimo de las nuevas terapias. Por tanto, nuestro objetivo principal fue estudiar los parámetros descritos como marcadores de inmunosenescencia en los pacientes con CPNM y comprobar si existen alteraciones significativas con la edad. Entre los objetivos secundarios, se examinó la relación entre dichos marcadores y otras variables clínicas. Metodología El presente trabajo es un estudio prospectivo, transversal, descriptivo y analítico de los pacientes diagnosticados de CPNM entre marzo-18 y febrero-21 en el Hospital U…