Search results for "Informatics"

"Nanodentistry": exploring the beauty of miniature

2011

Feynman’s early vision in 1959 gave birth to the concept of nanotechnology. He saw it as an unavoidable development in the progress of science and said that there is plenty of room at the bottom. Since then, nanotechnology has been part of mainstream scientific theory with potential medical and dental applications. Numerous theoretical predictions have been made based on the potential applications of nanotechnology in dentistry, with varying levels of optimism. While a few layers of nanotechnologic capability have become a reality for oral health in the last decade, many of these applications are still in their puerile stage .The most substantial contribution of nanotechnology to dentistry …

Realistic Implementation of the Particle Model for the Visualization of Nanoparticle Precipitation and Growth

2019

An application for visualizing the aggregation of structureless atoms is presented. The application allows us to demonstrate on a qualitative basis, as well as by quantitatively monitoring the aggregate surface/volume ratio, that the enhanced reactivity of nanoparticles can be connected with their large specific surface. It is suggested that, along with the use of geometric analogies, this bottom-up approach can be effective in discussing the enhanced reactivity proprieties of nanoparticles. The application is based on a two-dimensional realistic dynamic model where atoms move because of their thermal and interaction potential energies, and the trajectories are determined by solving numeric…

CellMap visualizes protein-protein interactions and subcellular localization [version 2; referees: 2 approved]

2018

Many tools visualize protein-protein interaction (PPI) networks. The tool introduced here, CellMap, adds one crucial novelty by visualizing PPI networks in the context of subcellular localization, i.e. the location in the cell or cellular component in which a PPI happens. Users can upload images of cells and define areas of interest against which PPIs for selected proteins are displayed (by default on a cartoon of a cell). Annotations of localization are provided by the user or through our in-house database. The visualizer and server are written in JavaScript, making CellMap easy to customize and to extend by researchers and developers.

A reliable and unbiased human protein network with the disparity filter

2017

AbstractThe living cell operates thanks to an intricate network of protein interactions. Proteins activate, transport, degrade, stabilise and participate in the production of other proteins. As a result, a reliable and systematically generated protein wiring diagram is crucial for a deeper understanding of cellular functions. Unfortunately, current human protein networks are noisy and incomplete. Also, they suffer from both study and technical biases: heavily studied proteins (e.g. those of pharmaceutical interest) are known to be involved in more interactions than proteins described in only a few publications. Here, we use the experimental evidence supporting the interaction between protei…

Bioinformatics and Computational Biology

2009

Bioinformatics is a new, rapidly expanding field that uses computational approaches to answer biological questions (Baxevanis, 2005). These questions are answered by means of analyzing and mining biological data. The field of bioinformatics or computational biology is a multidisciplinary research and development environment, in which a variety of techniques from computer science, applied mathematics, linguistics, physics, and, statistics are used. The terms bioinformatics and computational biology are often used interchangeably (Baldi, 1998; Pevzner, 2000). This new area of research is driven by the wealth of data from high throughput genome projects, such as the human genome sequencing pro…

Conceptualizations of Cyberchondria and Relations to the Anxiety Spectrum: Systematic Review and Meta-analysis

2021

Background Cyberchondria describes the detrimental effects of health-related internet use. Current conceptualizations agree that cyberchondria is associated with anxiety-related pathologies and may best be conceptualized as a safety behavior; however, little is known about its exact underlying mechanisms. Objective This systematic review and meta-analysis aims to give an overview of the conceptualizations of cyberchondria and its relation to anxiety-related pathologies, quantify the strength of association to health anxiety by using meta-analyses, highlight gaps in the literature, and outline a hypothetical integrative cognitive-behavioral model of cyberchondria based on the available empi…

Teaching and Learning School Informatics: A Concept-Based Pedagogical Approach

2009

While informatics is a well-established discipline in higher education around the world, it is not the case in secondary education, with the exception of a few countries. Generally, what is taught is not informatics as a subject with its own methods, concepts, and principles, but some software tools with the goal that the use is sufficient for students to acquire skills. In addition, an analysis of the current situation reveals that the real competencies of teachers and students in informatics are far weaker than might be expected in secondary education. This work proposes a concept-based pedagogical approach to school informatics. The aim is to provide the students with a more thorough und…

Time-resolved imaging of pulse-induced magnetization reversal with a microwave assist field

2015

AbstractThe reversal of the magnetization under the influence of a field pulse has been previously predicted to be an incoherent process with several competing phenomena such as domain wall relaxation, spin wave-mediated instability regions and vortex-core mediated reversal dynamics. However, there has been no study on the direct observation of the switching process with the aid of a microwave signal input. We report a time-resolved imaging study of magnetization reversal in patterned magnetic structures under the influence of a field pulse with microwave assistance. The microwave frequency is varied to demonstrate the effect of resonant microwave-assisted switching. We observe that the swi…

2015

AbstractAtomic manipulation in the scanning tunnelling microscopy, conventionally a tool to build nanostructures one atom at a time, is here employed to enable the atomic-scale imaging of a model low-dimensional system. Specifically, we use low-temperature STM to investigate an ultra thin film (4 atomic layers) of potassium created by epitaxial growth on a graphite substrate. The STM images display an unexpected honeycomb feature, which corresponds to a real-space visualization of the Wigner-Seitz cells of the close-packed surface K atoms. Density functional simulations indicate that this behaviour arises from the elastic, tip-induced vertical manipulation of potassium atoms during imaging,…

Alignment of cone beam computed tomography data using intra-oral fiducial markers.

2009

This article illustrates a new method to align and merge two partially overlapping volumes each of them generated by cone beam computed tomography (CBCT). The aggregate volume covers a larger area of investigation and is determined by localizing one fixed LEGO brick in both of the primal volumes. Based on the LEGO brick an approximate registration of the volumes is determined. Afterwards we improve the transformation by minimizing the difference in overlapping space. In this paper we present a method which automates these two steps and provides an aligned volume.