Search results for "Information Science"

showing 10 items of 3627 documents

Exploiting Cryo-EM Structural Information and All-Atom Simulations To Decrypt the Molecular Mechanism of Splicing Modulators.

2019

Splicing modulators (SMs) pladienolides, herboxidienes, and spliceostatins exert their antitumor activity by altering the ability of SF3B1 and PHF5A proteins, components of SF3b splicing factor, to recognize distinct intron branching point sequences, thus finely calibrating constitutive/alternative/aberrant splicing of pre-mRNA. Here, by exploiting structural information obtained from cryo-EM data, and by performing multiple μs-long all-atom simulations of SF3b in apo form and in complex with selected SMs, we disclose how these latter seep into the narrow slit at the SF3B1/PHF5A protein interface. This locks the intrinsic open/closed conformational transitions of SFB1's solenoidal structure…

Cryo-electron microscopyGeneral Chemical EngineeringRNA SplicingComputational biologyLibrary and Information SciencesEncryption01 natural sciencesSplicing factorAtom (programming language)0103 physical sciencesRNA PrecursorsAberrant splicingPhysics010304 chemical physicsbusiness.industryCryoelectron MicroscopyIntronGeneral ChemistryPhosphoproteins0104 chemical sciencesComputer Science Applications010404 medicinal & biomolecular chemistrySettore CHIM/03 - Chimica Generale E InorganicaRNA splicingMolecular mechanismRNA Splicing FactorsbusinessJournal of chemical information and modeling
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La cuisine a-t-elle un sexe ?

2018

Le genre féminin et masculin, dans les métiers de bouche comme dans la vie ménagère, est le coeur de l'évolution d'une société. L'homme aux fourneaux des cuisines des grands restaurants, la femme chargée de la préparation du repas quotidien, sont autant des stéréotypes, des caricatures que des réalités encore présentes. Les modes et conduites alimentaires individuelles ou communautaires font également naitre des relations particulières avec la nourriture, assignées à chacun des genres : la privation pour les femmes et l'excès pour les hommes. Cet ouvrage regorge de nombreuses études, remarques et recommandations, qui appellent à consacrer davantage de temps à construire une égalité entre le…

Cuisine[SHS.SOCIO] Humanities and Social Sciences/Sociology[SHS.HIST] Humanities and Social Sciences/History[SHS.EDU] Humanities and Social Sciences/EducationFeminisme[SHS.INFO] Humanities and Social Sciences/Library and information sciences
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Focus sur Marc Meneau, le cuisinier des champs devenu "sain père" de Vézelay

2014

International audience; Marc Meneau, grand chef cuisinier, a créé un “pèlerinage gastronomique” à quelques kilomètres de la basilique de Vézelay (Yonne). Il y valorise les produits régionaux, avec des recettes inspirées par la spiritualité du lieu. Non seulement il a fait de son village une destination de court séjour, mais, en outre, il l’a fait renouer avec une tradition vinicole oubliée. Il fait partie des six grands chefs grâce à qui la Bourgogne peut fièrement se revendiquer comme “une des capitales de la gastronomie”.

Cuisinier[SHS.SOCIO]Humanities and Social Sciences/Sociology[ SHS.HIST ] Humanities and Social Sciences/HistoryCuisine[SHS.SOCIO] Humanities and Social Sciences/Sociology[SHS.INFO]Humanities and Social Sciences/Library and information sciences[SHS.GEO] Humanities and Social Sciences/Geography[ SHS.SOCIO ] Humanities and Social Sciences/Sociology[SHS.GEO]Humanities and Social Sciences/Geography[SHS.INFO] Humanities and Social Sciences/Library and information sciences[ SHS.GEO ] Humanities and Social Sciences/Geography[SHS.HIST] Humanities and Social Sciences/History[ SHS.INFO ] Humanities and Social Sciences/Library and information sciencesBourgogne[SHS.HIST]Humanities and Social Sciences/HistoryChef
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Jeu communicationnel des cuisiniers : des registres de discours variés

2017

International audience

Cuisinier[SHS.SOCIO]Humanities and Social Sciences/Sociology[ SHS.HIST ] Humanities and Social Sciences/History[SHS.SOCIO] Humanities and Social Sciences/Sociology[SHS.INFO]Humanities and Social Sciences/Library and information sciences[SHS.EDU]Humanities and Social Sciences/Education[SHS.EDU] Humanities and Social Sciences/Education[ SHS.EDU ] Humanities and Social Sciences/Education[ SHS.SOCIO ] Humanities and Social Sciences/Sociology[SHS.INFO] Humanities and Social Sciences/Library and information sciences[SHS.HIST] Humanities and Social Sciences/History[ SHS.INFO ] Humanities and Social Sciences/Library and information sciences[SHS.HIST]Humanities and Social Sciences/HistoryComputingMilieux_MISCELLANEOUS
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Le vin et l’éveil des sens. L’expérience du goût en partage

2016

International audience; Entre tous les éléments de la scène alimentaire, le vin offre sans conteste le plus large espace de représentation, de figuration. Tout fait sens en lui, prend valeur de signe, de figure : la terre et le terroir, le climat et la vigne, le travail en cave, la bouteille et l'étiquette, la table et les relations commensales, conviviales. Tout ce monde de signes, ce peuple de figures, donne saveur et valeur à nos émotions gustatives. Elles relèvent déjà d'un ordre sensoriel, du domaine de l'expertise mais avec des grilles et des normes de qualification, de catégorisation désormais entrées dans l'appréciation courante du vin lorsqu'on s'attarde sur sa dégustation. Au-delà…

Cultural StudiesDéploiement figuratif et sensorielSociology and Political Science[SHS.INFO]Humanities and Social Sciences/Library and information sciencesCommunicationmedia_common.quotation_subjectExpérience sensorielle et digitaleArt[SHS.INFO] Humanities and Social Sciences/Library and information sciencesAnalyse sensorielleVin[ SHS.INFO ] Humanities and Social Sciences/Library and information sciencesHumanitiesmedia_commonHermès
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A New Weber for the International Academic Audience

2020

It has been almost a century since Max Weber’s Wirtschaft und Gesellschaft was first published and for the first time we have an English translation of the text as it most truly originally stood. T...

Cultural StudiesHistoryArts and Humanities (miscellaneous)PhilosophyLibrary and Information SciencesClassicsGlobal Intellectual History
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The parliamentary momentum

2019

Democracy, participation, deliberation and representation have been the leading slogans of recent decades in academic political theorising. Remarkable studies have been written in terms of each of ...

Cultural StudiesHistoryPoliticsMomentum (finance)Arts and Humanities (miscellaneous)media_common.quotation_subjectPolitical scienceRepresentation (systemics)Library and Information SciencesDeliberationDemocracymedia_commonEpistemologyGlobal Intellectual History
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Negations and negativity as linguistic devices in policy discourse of intercultural cities

2015

International audience; Intercultural cities – a joint initiative launched in 2008 by the European Commission and the Council of Europe – aims to develop a model supporting intercultural integration within diversified urban communities. This article examines, using methods of applied linguistics and discourse analysis, how intercultural urban policy is linguistically produced in the initiative. The examination indicates that the intercultural urban policy in the initiative is ‘negative politics’: the policy rhetoric commonly outlines the content of interculturalism by describing what is not included in it and what the policy is not about. The language used in the intercultural urban policy …

Cultural StudiesLinguistics and LanguageDiscourse analysismedia_common.quotation_subject[SHS.INFO]Humanities and Social Sciences/Library and information sciencesta6121kaupunkipolitiikka[SHS]Humanities and Social SciencesPoliticsNegationurban policynegativitykielita616Sociologyinterculturalismdiscourse analysiskulttuurienvälisyysmedia_common[SHS.SOCIO]Humanities and Social Sciences/SociologylanguageCommunicationnegationsNegativity effectApplied linguisticsLinguisticsdiskurssianalyysiIntercultural relationsnegatiivisuusRhetoricInterculturalismJournal of Multicultural Discourses
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¿Guerrilla unisex? Ser mujer u hombre en el conflicto guatemalteco a partir de los testimonios de combatientes

2016

Resumen: A partir de los testimonios de combatientes guatemaltecos: Autobiografia de una guerriglia (Ramirez, 1969), Los dias de la selva (Payeras, 1980), Rosa Maria, una mujer en la guerrilla. Relatos de la insurgencia guatemalteca en los anos sesenta (Paiz Carcamo, 2015), Mujeres en la alborada (Colom, 1998) y Ese obstinado sobrevivir. Autoetnografia de una mujer guatemalteca (Arriola, 2000); el texto analiza los posibles cambios acaecidos en las relaciones de genero en la sociedad guatemalteca durante y despues de la gesta revolucionaria. Palabras clave: Genero, testimonio, Guatemala y estereotipos. Abstract: The text analyses the testimonies of Guatemalan combatants : Autobiografia de u…

Cultural StudiesLinguistics and LanguageHistoryUNESCO::CIENCIAS DE LAS ARTES Y LAS LETRASLiterature and Literary Theory[SHS.LITT]Humanities and Social Sciences/LiteratureCommunicationmedia_common.quotation_subject[SHS.INFO]Humanities and Social Sciences/Library and information sciencesHumanidadesArt16. Peace & justiceLanguage and Linguistics5. Gender equality:CIENCIAS DE LAS ARTES Y LAS LETRAS [UNESCO]Humanidades. Generalidades[SHS.LANGUE]Humanities and Social Sciences/Linguistics[SHS.GENRE]Humanities and Social Sciences/Gender studiesHumanitiesComputingMilieux_MISCELLANEOUSmedia_common
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No hay capital hecho sin sangre. Entrevista a Yolanda Colom

2016

Esta entrevista tuvo lugar en los dias seis y siete de julio de 2015 en Guatemala. Nos vimos el primer dia en la gran casa de la cultura y editorial Del Pensativo, de estilo colonial, afincada en la hermosa ciudad de Antigua. El segundo dia nos encontramos en la Universidad Rafael Landivar, en ciudad de Guatemala, donde la autora habia sido invitada a un encuentro con estudiantes de literatura para hablar sobre su testimonio y responder a los interrogantes surgidos tras la lectura de su libro en el seno de este grupo de jovenes. La generosidad y simpatia con las que Yolanda Colom relata su vida, su sonrisa y su profunda mirada acompanando sus palabras han hecho de este encuentro un maravill…

Cultural StudiesLinguistics and LanguageHistoryUNESCO::CIENCIAS DE LAS ARTES Y LAS LETRASLiterature and Literary Theory[SHS.LITT]Humanities and Social Sciences/LiteratureCommunicationmedia_common.quotation_subject[SHS.INFO]Humanities and Social Sciences/Library and information sciencesHumanidadesArtLanguage and Linguistics:CIENCIAS DE LAS ARTES Y LAS LETRAS [UNESCO]Humanidades. Generalidades[SHS.LANGUE]Humanities and Social Sciences/Linguistics[SHS.GENRE]Humanities and Social Sciences/Gender studiesHumanitiesComputingMilieux_MISCELLANEOUSmedia_common
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