Search results for "Information Science"

Beyond the Cultural Turn: A Critical Perspective on Culture-Discourse within Public Relations

2017

International audience; In 1992, Sriramesh and White (1992) pointed to the importance of culture for public relations. Two decades later, public relations scholars had answered their call in force (e.g., Bardhan & Weaver, 2011; Carayol & Frame, 2012; Edwards & Hodges, 2011; Sriramesh & Vercic, 2012). Sriramesh and other PR scholars have criticized much previous public relations research for its focus on the work of Hofstede and cultural characteristics that are apparently common across countries (Sriramesh, 2009), rather than approaches which present culture as a social phenomenon on the level of the social group (Frame, 2012), or as a communication resource or tool-kit (Swidler, 1986). Sri…

2020

Abstract Information technology (IT) engagement is defined as a need to spend more time using IT. Practice-based examples show that IT engagement can have adverse effects in organizations. Although users can potentially get more work done through IT engagement, observations show that the users might jeopardize their well-being and hamper their work performance. We aimed to investigate this complexity in the research on IT engagement by examining its potential antecedents and outcomes in organizations. Considering the potentially mixed outcomes, we developed a model to examine the effects of IT engagement on personal productivity and strain. We also aimed to explain the antecedents of IT eng…

Customer’s role in knowledge management and in the innovation process: effects on innovation capacity and marketing results

2016

Scholars have acknowledged customer knowledge management (CKM) as a key strategic resource for improving innovation and supporting long-term customer relationship management. This study provides a deeper understanding of the internal antecedents of business innovation capacity overcoming previous approaches. A model that had not previously been tested was used to analyse the role of customer collaboration and CKM – measured as a second-order construct – in innovation processes and marketing results. To test the model, structural equation modelling (partial least squares) was applied to a random sample of 210 Spanish companies. Results confirm that CKM and customer collaboration are antecede…

Comparison of virtual high-throughput screening methods for the identification of phosphodiesterase-5 inhibitors.

2011

Reliable and effective virtual high-throughput screening (vHTS) methods are desperately needed to minimize the expenses involved in drug discovery projects. Here, we present an improvement to the negative image-based (NIB) screening: the shape, the electrostatics, and the solvation state of the target protein’s ligand-binding site are included into the vHTS. Additionally, the initial vHTS results are postprocessed with molecular mechanics/generalized Born surface area (MMGBSA) calculations to estimate the favorability of ligand-protein interactions. The results show that docking produces very good early enrichment for phosphodiesterase-5 (PDE-5); however, in general, the NIB and the ligand-…

Post-Translational Regulation of CYP450s Metabolism As Revealed by All-Atoms Simulations of the Aromatase Enzyme.

2019

Phosphorylation by kinases enzymes is a widespread regulatory mechanism able of rapidly altering the function of target proteins. Among these are cytochrome P450s (CYP450), a superfamily of enzymes performing the oxidation of endogenous and exogenous substrates thanks to the electron supply of a redox partner. In spite of its pivotal role, the molecular mechanism by which phosphorylation modulates CYP450s metabolism remains elusive. Here by performing microsecond-long all-atom molecular dynamics simulations, we disclose how phosphorylation regulates estrogen biosynthesis, catalyzed by the Human Aromatase (HA) enzyme. Namely, we unprecedentedly propose that HA phosphorylation at Y361 markedl…

The International Comparable Corpus: Challenges in building multilingual spoken and written comparable corpora

2021

This paper reports on the efforts of twelve national teams in building the International Comparable Corpus (ICC; https://korpus.cz/icc) that will contain highly comparable datasets of spoken, written and electronic registers. The languages currently covered are Czech, Finnish, French, German, Irish, Italian, Norwegian, Polish, Slovak, Swedish and, more recently, Chinese, as well as English, which is considered to be the pivot language. The goal of the project is to provide much-needed data for contrastive corpus-based linguistics. The ICC corpus is committed to the idea of re-using existing multilingual resources as much as possible and the design is modelled, with various adjustments, on t…

Effet de l'orientation des fibres des plis adjacents sur la résistance au délaminage en mode I pur = Effect of the fibre's orientation of adjacent pl…

2009

National audience; Ce travail concerne l'étude de l'effet de l'orientation des fibres des plis adjacents à la fissure dans une éprouvette DCB (Double Cantilever Beam) sur la résistance au délaminage en mode I pur. Afin d'isoler l'influence de l'orientation l'étude porte sur des stratifiés particuliers ayant tous les mêmes matrices de comportement global A B D. Les résultats expérimentaux montrent une grande variation de résistance au délaminage GIC et des courbes R selon l'orientation des plis situés de part et d'autre du plan de fissure. Une modélisation par éléments finis permet de mettre en évidence l'importance de l'état de contraintes locales et donc de l'endommagement au voisinage du …

Information territoriale : une construction collective nécessaire

2011

Les récents événements sociaux observés au niveau mondial, des crises financières et économiques à la crise sociale actuelle, poussent à imaginer de nouveaux modes de conception d'une organisation territoriale revisitée. Il semble inopportun dans le contexte actuel de continuer à vouloir structurer des sociétés selon des schémas verticaux (du haut vers le bas, du bas vers le haut) sans une réelle co-construction d'une vision concertée des enjeux comme des besoins sociaux. Décréter la participation citoyenne ne suffit pas ; l'appropriation d'une vision prospective s'avère parcellaire car encore inscrite dans une expression extra-territoriale dominante et surtout dans un schéma autoritaire. L…

Computational Models That Matter During a Global Pandemic Outbreak

2020

The COVID-19 pandemic is causing a dramatic loss of lives worldwide, challenging the sustainability of our health care systems, threatening economic meltdown, and putting pressure on the mental health of individuals (due to social distancing and lock-down measures). The pandemic is also posing severe challenges to the scientific community, with scholars under pressure to respond to policymakers’ demands for advice despite the absence of adequate, trusted data. Understanding the pandemic requires fine-grained data representing specific local conditions and the social reactions of individuals. While experts have built simulation models to estimate disease trajectories that may be enough to gu…

Quantum-state transfer via resonant tunneling through local-field-induced barriers

2013

Efficient quantum-state transfer is achieved in a uniformly coupled spin-1/2 chain, with open boundaries, by application of local magnetic fields on the second and last-but-one spins, respectively. These effective barriers induce the appearance of two eigenstates, bilocalized at the edges of the chain, which allow a high-quality transfer also at relatively long distances. The same mechanism may be used to send an entire e-bit (e.g., an entangled qubit pair) from one to the other end of the chain. DOI: 10.1103/PhysRevA.87.042313