Search results for "Ingold"
showing 5 items of 5 documents
The MRN complex is transcriptionally regulated by MYCN during neural cell proliferation to control replication stress
2015
The MRE11/RAD50/NBS1 (MRN) complex is a major sensor of DNA double strand breaks, whose role in controlling faithful DNA replication and preventing replication stress is also emerging. Inactivation of the MRN complex invariably leads to developmental and/or degenerative neuronal defects, the pathogenesis of which still remains poorly understood. In particular, NBS1 gene mutations are associated with microcephaly and strongly impaired cerebellar development, both in humans and in the mouse model. These phenotypes strikingly overlap those induced by inactivation of MYCN, an essential promoter of the expansion of neuronal stem and progenitor cells, suggesting that MYCN and the MRN complex migh…
Novel examples of the N-methyl effect on cyclisations of N-Boc derivatives of amino alcohols. A theoretical study
2004
New examples of the N-methyl effect on the cyclisation of N-tert-butoxycarbonyl derivatives of amino alcohols are reported. Ab initio studies for the displacement step with formation of the five-membered heterocycle indicate that the increase of the nucleophile character of the carbonyl oxygen of the carbamate group with the N-methyl substitution is responsible for the acceleration of the cyclisation step.
Nothing matters: the significance of the unidentifiable, the superficial and nonsense
2019
ABSTRACT Purpose: The aim of this study is to explore the ways in which “small things” may be of importance for people with mental health difficulties. Method: Empirical material from three different studies was reanalysed through a phenomenological, dialogical, approach. Results: We discovered some paradoxical aspects of small things: i.e., they could be about “something” that was difficult or even impossible to identify. The unidentifiable could be about bodily, sensual experiences that are superficial (i.e., belonging to the surface). The interaction with others highlighted as significant could be about doing something fun, talking nonsense or kidding around, and hence not at all about m…
Arte da Linguagem na Era da Panofonia
2018
This article calls attention to the hybrid genre of voice-based performances and its blending of the supposed binaries of human and machinic speech. Using the concept of panophonia, the author refers to the animatronic sculptures of speaking figures created by Ken Feingold and to Mark Böhlen’s talking robots. Through their comparative analysis, the author explores different poetic metalanguages both artists create to deconstruct communicative structures that demarcate post-human era.
Animalità, umanità, cultura, vita. A margine della discussione tra antropologi socioculturali.
2017
L'articolo ricostruisce alcuni momenti del dibattito sui rapporti tra umanità e animalità, evidenziando, sulla scorta di Ingold, come l'umanità sia stata pensata sia in quanto appartenenza a una specie biologica, sia in quanto condizione distintiva rispetto all'animalità. La necessità di dovere superare le antinomie che derivano dall'attribuzione di questo doppio statuto all'essere umano passa per un ripensamento del concetto di cultura