Search results for "Inherited"
showing 7 items of 77 documents
An inherited name as the foundation of a person's identity: How the memory of a dead person lived on in the names of his or her descendants
2012
A personal name has always played a central role in the formation of an individual’s identity. In addition to the surname, the forename also defined his or her place within the family community, which for most people was the most important target in the identification process, especially in the early modern period. The identities of the persons in rural families were also to a great extent based on personal names inherited from forebears and the images thus created. In this article, I examine to what extent the naming practices of the population in the hinterland Finnish countryside and the identities created by them were connected with ancestors. The study spans a quite long period, from t…
Hereditary angio-oedema with normal C1 inhibitor in a family with affected women and men
2005
Recurrent angio-oedema is a sign of various acquired and inherited disease entities, including hereditary angio-oedema types I and II that result from a genetic deficiency of C1 inhibitor, and a recently described type of dominantly inherited angio-oedema, which does not show a deficiency of C1 inhibitor. Until now, this new type of hereditary angio-oedema, designated as hereditary angio-oedema type III, has been assumed to be a disorder specific to females. We now describe a four-generation family with dominantly inherited angio-oedema and normal C1 inhibitor in which, in contrast to all previous observations, not only five female but also three male family members were clinically affected…
Could inherited predisposition drive fatty liver disease in non-obese Germans? Results from eight tertiary referral centers
2018
The ISTH bleeding assessment tool as predictor of bleeding events in inherited platelet disorders: Communication from the ISTH SSC Subcommittee on Pl…
2021
Background: The ISTH Bleeding Assessment Tool (ISTH-BAT) has been validated for clinical screening of suspected von Willebrand disease (VWD) and for bleeding prediction. Recently it has been validated for subjects with inherited platelet disorders (IPD) (BAT-VAL study). Objectives: To determine whether the ISTH-BAT bleeding score (BS) predicts subsequent bleeding events requiring treatment in IPD patients. Methods: Patients with IPD, type 1 VWD (VWD-1) and age- and sex-matched healthy controls enrolled in the BAT-VAL study were prospectively followed-up for 2 years and bleeding episodes requiring treatment were recorded. Results: Of the 1098 subjects initially enrolled, 955 were followed-up…
Congenital Factor VII Deficiency
2007
Induction of body weight loss through RNAi-knockdown of APOBEC1 gene expression in transgenic rabbits
2014
In the search of new strategies to fight against obesity, we targeted a gene pathway involved in energy uptake. We have thus investigated the APOB mRNA editing protein (APOBEC1) gene pathway that is involved in fat absorption in the intestine. The APOB gene encodes two proteins, APOB100 and APOB48, via the editing of a single nucleotide in the APOB mRNA by the APOBEC1 enzyme. The APOB48 protein is mandatory for the synthesis of chylomicrons by intestinal cells to transport dietary lipids and cholesterol. We produced transgenic rabbits expressing permanently and ubiquitously a small hairpin RNA targeting the rabbit APOBEC1 mRNA. These rabbits exhibited a moderately but significantly reduced …
La desheredación del menor de edad
2021
This work aims to answer the eternal question of the disinheritance of the child under legal age. To this end, we will approach the institute of disinheritance, its foundation and its jurisprudential evolution. We will also address the capacity and responsibility of the child under legal age and the emancipated minor. Subsequently, we will carry out the study of the disinheritance of the child under legal age, subject to the whim of the specific disinherited causes, since each of the causes provided for in art. 853 Spanish Civil Code are endowed with their own idiosyncrasy, being very complicated, if not impossible, to deal with the subject of this work apart from the vicissitudes that can …