Search results for "Initiation"
showing 10 items of 174 documents
Physical activity, sugar-sweetened beverages, whole grain bread and insomnia among adolescents and psychological distress in adulthood: prospective d…
2021
Abstract Background In this study, we examined the relationship between low levels of physical activity, high consumption of sugar-sweetened beverages and low consumption of whole grain bread and experiencing insomnia in adolescence and psychological distress in young adults. Methods This prospective study was based on information retrieved from the Trøndelag Health Study (HUNT) in Norway and included adolescents (age 13–19) participating in Young-HUNT3 (2006–2008) and in HUNT4 (2017–2019) 11 years later (age 23–31). The study sample consisted of 2,230 participants (1,287 females and 943 males). The exposure variables collected in adolescence included self-reported physical activity, consum…
eIF2α confers cellular tolerance to S. aureus α-toxin
2015
We report on the role of conserved stress-response pathways for cellular tolerance to a pore forming toxin. First, we observed that small molecular weight inhibitors including of eIF2α-phosphatase, jun-N-terminal kinase (JNK), and PI3-kinase sensitized normal mouse embryonal fibroblasts (MEFs) to the small pore forming S. aureus α-toxin. Sensitization depended on expression of mADAM10, the murine ortholog of a proposed high-affinity receptor for α-toxin in human cells. Similarly, eIF2α (S51A/S51A) MEFs, which harbor an Ala knock-in mutation at the regulated Ser51 phosphorylation site of eukaryotic translation initiation factor 2α, were hyper-sensitive to α-toxin. Inhibition of translation w…
Wybrane aspekty odpowiedzialności z tytułu zdarzeń medycznych podmiotów leczniczych prowadzących szpital
2016
Przedmiotem artykułu jest zastosowanie odpowiedzialności z tytułu zdarzeń medycznych oraz formalne wszczęcie odpowiedniego postępowania w tym zakresie. Autor zwraca szczególną uwagę na te kwestie, które powodują istotne problemy interpretacyjne, a także wymagają komentarza co do poprawności i słuszności rozwiązań przyjętych przez ustawodawcę. Omawia pojęcie „zdarzenia medycznego”, krąg podmiotów uprawnionych do wszczęcia postępowania w przedmiocie odpowiedzialności za zdarzenia medyczne oraz kwestie dotyczące złożenia wniosku do właściwej komisji i opisania jego wymogów formalnych.
Cognitive behavioural therapy interventions for insomnia among shift workers: RCT in an occupational health setting
2019
Abstract Introduction The aim of the study was to compare the effectiveness of cognitive behavioural therapy interventions for insomnia (CBT-I) to that of a sleep hygiene intervention in a randomized controlled design among shift workers. We also studied whether the features of shift work disorder (SWD) affected the results. Methods A total of 83 shift workers with insomnia disorder were partially randomized into a group-based CBT-I, self-help CBT-I, or sleep hygiene control intervention. The outcomes were assessed before and after the interventions and at 6-month follow-up using questionnaires, a sleep diary, and actigraphy. Results Perceived severity of insomnia, sleep-related dysfunction…
A subunit of eukaryotic translation initiation factor 2α-phosphatase (CreP/PPP1R15B) regulates membrane traffic.
2012
The constitutive reverter of eIF2α phosphorylation (CReP)/PPP1r15B targets the catalytic subunit of protein phosphatase 1 (PP1c) to phosphorylated eIF2α (p-eIF2α) to promote its dephosphorylation and translation initiation. Here, we report a novel role and mode of action of CReP. We found that CReP regulates uptake of the pore-forming Staphylococcus aureus α-toxin by epithelial cells. This function was independent of PP1c and translation, although p-eIF2α was involved. The latter accumulated at sites of toxin attack and appeared conjointly with α-toxin in early endosomes. CReP localized to membranes, interacted with phosphomimetic eIF2α, and, upon overexpression, induced and decorated a pop…
Inattentiveness, parental smoking and adolescent smoking initiation
2004
Aims To examine how adolescents’ inattentive behaviour, together with parental smoking patterns, predicts smoking initiation by age 14. Design, settings A prospective, longitudinal study: baseline at ages 11–12, follow-up at age 14. A population-based sample of Finnish twins, born 1983–1987, with parents and classroom teachers as additional informants. Two groups were formed, allocating the co-twins of each family into separate groups: the study sample and a replication sample. Participants Twin individuals (n = 4552), aged 11–12 at baseline and 14 (average 14.04 years) at follow-up. Measurements At baseline, inattentiveness was assessed with the Multidimensional Peer Nomination Invento…
Identification and expansion of human colon-cancer-initiating cells
2007
Colon carcinoma is the second most common cause of death from cancer. The isolation and characterization of tumorigenic colon cancer cells may help to devise novel diagnostic and therapeutic procedures. Although there is increasing evidence that a rare population of undifferentiated cells is responsible for tumour formation and maintenance, this has not been explored for colorectal cancer. Here, we show that tumorigenic cells in colon cancer are included in the high-density CD133+ population, which accounts for about 2.5% of the tumour cells. Subcutaneous injection of colon cancer CD133+ cells readily reproduced the original tumour in immunodeficient mice, whereas CD133- cells did not form …
¿Depende el desarrollo de la RAN de la edad de inicio de la lectoescritura?
2018
Antecedentes:La habilidad del alumno para nombrar rápidamente estímulos familiares (RAN) es un factor implicado en el rendimiento lector evaluable de forma indiscriminada a lo largo de los primeros años de escolarización. El objetivode este estudio, pues, es analizar si la adquisición de dicha habilidad depende de variables relacionadas con una iniciación temprana a la lecto-escritura o si su desarrollo se relaciona con factores de madurez cronológica. Método: Para ello se aplicó la prueba RAN a 71 niños de 6-7 años croatas (cultura en la que la iniciación a la lectura es más tardía); a 44 niños de 4-5 años españoles (equiparando los dos grupos por edad de inicio de la lecto-escritura) y a …
Fertility and Polarized Cell Growth Depends on eIF5A for Translation of Polyproline-Rich Formins in Saccharomyces cerevisiae
2014
eIF5A is an essential and evolutionary conserved translation elongation factor, which has recently been proposed to be required for the translation of proteins with consecutive prolines. The binding of eIF5A to ribosomes occurs upon its activation by hypusination, a modification that requires spermidine, an essential factor for mammalian fertility that also promotes yeast mating. We show that in response to pheromone, hypusinated eIF5A is required for shmoo formation, localization of polarisome components, induction of cell fusion proteins, and actin assembly in yeast. We also show that eIF5A is required for the translation of Bni1, a proline-rich formin involved in polarized growth during …
Student-initiated multi-unit questions in EMI classrooms
2021
This conversation analytic study investigates student-initiated multi-unit questions (MUQs) in whole class interaction. Based on a corpus of 30 hours of videotaped interactions from teacher education classrooms in an English-medium instruction university, we demonstrate that students use MUQs to introduce topics, either by recontextualizing some aspect of the prior topic, or alternatively, without these cohesive ties, which requires more interactional work to achieve intersubjectivity. Findings reveal that MUQs render student professional concerns more relevant and salient, foregrounding those inquiries as a space for launching topics. Students bring up issues such as ways of handling parti…