Search results for "Injection"
showing 10 items of 920 documents
Rapid, reproducible transduction of select forebrain regions by targeted recombinant virus injection into the neonatal mouse brain
2009
Viral vectors can mediate long-term gene expression in different regions of the brain. Recombinant adeno-associated virus (rAAV) and Lenti virus (LV) have both gained prominence due to their ability to achieve specific transduction of various neuronal populations. Whilst widespread gene delivery has been obtained by targeted injection of rAAV in various brain structures, LV has also been utilized for infection of stem cell populations for cell lineage tracing. Both viral vector systems are most commonly used for gene delivery in mature brains, but the great potential of somatic gene delivery into the neonate brain has not been systematically exploited. Here we provide a systematic guideline…
Flexible Spare Core Placement in Torus Topology based NoCs and its validation on an FPGA
2021
In the nano-scale era, Network-on-Chip (NoC) interconnection paradigm has gained importance to abide by the communication challenges in Chip Multi-Processors (CMPs). With increased integration density on CMPs, NoC components namely cores, routers, and links are susceptible to failures. Therefore, to improve system reliability, there is a need for efficient fault-tolerant techniques that mitigate permanent faults in NoC based CMPs. There exists several fault-tolerant techniques that address the permanent faults in application cores while placing the spare cores onto NoC topologies. However, these techniques are limited to Mesh topology based NoCs. There are few approaches that have realized …
Sorafenib for Hepatocellular Carcinoma: From Randomized Controlled Trials to Clinical Practice.
2015
Hepatocellular carcinoma is a challenging malignancy of global importance. It is the sixth most common solid malignancy and the third leading cause of cancer-related death, worldwide. Curative treatments at early stages include liver transplantation, resection and percutaneous ablation, while transarterial chemoembolization can improve survival in patients with intermediate tumor stage. Patients with mild, related symptoms and/or macrovascular invasion or extrahepatic spread are classified under the advanced stage. The standard of care in this group is sorafenib, an inhibitor of Raf kinase and vascular endothelial growth factor receptor, whose effectiveness has been proven by 2 recent rando…
Technique of CT and MR Examinations
1989
The three original groups participating in our study used the EMI Mark I scanner from 1975 to the middle of 1977 and the EMI CT 1010 scanner after mid-1977. The Siemens Somatom DR has been used in Augsburg and Berlin since 1983, and the Philips Tomoscan CT 350 in Mainz since mid-1986.
Recent developments in flow-analysis vibrational spectroscopy
2007
Abstract This review deals with developments in the new century on the use of vibrational spectroscopy techniques for detection in flow-injection analysis (FIA) systems. To provide a picture of the evolution, highlights and future developments in this field, we revisited Fourier transform infrared (FTIR), in the mid-IR and near-IR ranges, and FT-Raman spectrometry applications using different approaches, from classical FIA to modern (sequential injection analysis (SIA) or multicommutation). We used the analytical abstracts database for 2000–06 for the literature search, but we based this review very much on the experience of our team in this field.
Application of sequential injection analysis to pharmaceutical analysis.
2005
Sequential injection analysis is a well established tool for automation of pharmaceutical analysis. A short historical background of this technique is given as well as a brief discussion on the basic principles and potentials. The current applications of SIA in the pharmaceutical analysis are also described and discussed. The manifolds developed offer good analytical characteristics and are suitable for analysis of drug formulations, process analysis, drug-dissolution, drug-release testing and functional assays for screening potential drugs. The results obtained are in good agreement with those furnished by the application of the reference methods presented in the pharmacopoeias.
Scientometric Picture of the Evolution of the Literature of Automation in Spectroscopy and Its Current State
2006
Abstract The current study focuses on the status of automation and mechanization in spectroscopy for analytical chemistry publications compiled during the period 1980–2006, in Analytical Abstracts. Flow injection analysis (FIA), sequential injection analysis (SIA), multicommutation, and monosegmented and segmented flow strategies were considered. For assessing the evolution of scientific productivity, the total number of publications concerned with the different methodologies was evaluated. In order to provide a picture of the state of the art of this field, the most important journals, the most active authors, and the most productive countries in the field of automation were evaluated in t…
Recent applications of flow-injection and sequential-injection analysis techniques to chemiluminescence determination of pharmaceuticals
2007
Abstract A review is presented on the state of the art of the chemiluminescence analysis of pharmaceuticals by the two most relevant automated controlled-flow methodologies—flow-injection analysis (FIA) and sequential-injection analysis (SIA). The current chemiluminometric applications of FIA and SIA in pharmaceutical analysis are discussed with special emphasis on the analytical figures of merit and sample matrix characteristics. The review involving 211 references and covering papers published between 2001 and 2006 is divided into several sections according to the fundamental types of chemiluminescence systems employed.
Effectiveness of different vaccine formulations against vibriosis caused by Vibrio vulnificus serovar E (biotype 2) in European eels Anguilla anguilla
2001
Vibriosis due to Vibrio vulnificus serovar E (biotype 2) is one of the main causes of mortality in European eels cultured in Europe. The main objective of this study was to develop a vaccine and a vaccination procedure against this pathogen. With this aim, we tested several vaccine formulations (inactivated whole-cells with and without toxoids‹inactivated extracellular products‹from capsulated and uncapsulated strains, attenuated live vaccines and purified lipopolysaccharide [LPS]) on eels maintained under controlled laboratory conditions using different delivery routes (injection and immersion). To study the immune response we estimated antibody titers and bactericidal/bacteriostatic activ…
Efficacy of a bivalent vaccine against eel diseases caused by Vibrio vulnificus after its administration by four different routes
2003
Vulnivaccine, a vaccine against vibriosis caused by Vibrio vulnificus serovar E (formerly biotype 2), confers acceptable levels of protection to eels after its administration by prolonged immersion in three doses. Recently, a new pathogenic serovar, named serovar A, has been isolated from vaccinated eels in a Spanish freshwater eel farm. The main objective of this work was to design a bivalent vaccine, and to study its effectiveness against the two pathogenic serovars. With this aim, eels weighing around 20 g were immunised with the bivalent vaccine by oral and anal intubation, intraperitoneal injection (i.p.) and prolonged immersion. The overall results indicated that: (i) the new vaccine …