Search results for "Ink"

Spatial Cognition 2020/1: Book of abstracts : August 2-4, 2021, University of Latvia

2021

Spatial Cognition is concerned with the acquisition, development, representation, organization, and use of knowledge about spatial objects in real, virtual or hybrid environments and processed by human or artificial agents. Spatial Cognition includes research from different fields insofar as they are concerned with cognitive agents and space, such as cognitive and developmental psychology, linguistics, computer science, geography, cartography, philosophy, neuroscience, and education. Research issues in the field range from the investigation of human spatial cognition to mobile robot navigation, including topics such as wayfinding, spatial planning, spatial learning, internal and external re…

Media landscapes in school and in free time – two paralel realities?

2008

This article is based on an extensive research project (Towards Future Literacy Pedagogies, ToLP1 ) that deals with the literacy practices of Finnish and immigrant pupils, mother tongue (MT) and foreign language (FL) teachers. The overall aim of the project is to explore and interpret literacy practices both in school and out-of-school contexts by employing large-scale quantitative research approaches as well as qualitative classroom observations and teacher and pupil interviews. In this article, we will report findings of the comprehensive survey, our specific focus being on the materials and media the teachers and pupils use in school and in their free time. We are interested in exploring…

Transcriptional profiles from patients with dystrophinopathies and limb girdle muscular dystrophies as determined by qRT-PCR.

2003

Mutations in genes coding for the dystrophin-glycoprotein complex (DGC) cause inherited muscular dystrophies (MD), including Morbus Duchenne (DMD) and M. Becker (BMB) as well as limb-girdle muscular dystrophies (LGMD). New insights into the pathophysiology of the dystrophic muscle, the identification of compensatory mechanisms and additional proteins interacting with dystrophin are essential for developing new treatments. In order to define molecular mechanisms induced by lack of dystrophin and the subsequent counter-regulatory transcriptional response of degenerating muscle fibres, we have investigated the mRNA expression of 19 functionally linked genes in biopsies of patients with MD by m…

Micromechanical Properties and Collagen Composition of Ruptured Human Achilles Tendon

2012

Background:The Achilles tendon is one of the strongest tendons in the human body, and yet it frequently ruptures, which is a substantial clinical problem. However, the cause of ruptures remains elusive.Hypothesis:Ruptured human Achilles tendon displays inferior biomechanical properties and altered collagen composition compared with noninjured tendon.Study Design:Controlled laboratory study.Methods:Biopsy specimens were obtained at the rupture site and the noninjured part of the tendon (internal controls) in 17 patients with acute Achilles tendon rupture. Age- and weight-matched human cadaveric Achilles tendons (external controls) were also obtained. Tendon samples were tested micromechanica…

Analysis of HLA-DRB1,DQA1,DQB1 haplotypes in Sardinian centenarians

2008

Some genetic determinants of longevity might reside in those polymorphisms for the immune system genes that regulate immune responses. Many longevity association studies focused their attention on HLA (the human MHC) polymorphisms, but discordant results have been obtained. Sardinians are a relatively isolate population and represent a suitable population for association studies. Some HLA-DR and DQ alleles form very stable haplotypes with a strong linkage disequilibrium. In a previous study on Sardinian centenarians we have suggested that HLA-DRB1 *15 allele might be marginally associated to longevity. HLA-DR,DQ haplotypes are in strong linkage disequilibrium and well conserved playing a ro…

Osteogenic differentiation of periodontal fibroblasts is dependent on the strength of mechanical strain

2012

Abstract Objective During orthodontic therapy the correct strength of mechanical strain plays a key role for bone remodelling during tooth movement. Aim of this study was to investigate the osteogenic differentiation of human periodontal ligament fibroblasts (HPdLF) depending on the applied strength of mechanical strain compared to osteoblasts (HOB). Design HPdLF and HOB were loaded with different strengths (1%, 5% and 10%) of static mechanical strain (SMS) for 12 h in vitro. Viability was verified by MTT and apoptosis by TUNEL assay. Gene expression of cyclin D1, collagen type-1 (COL-I), alkaline phosphatase (ALP), osteocalcin, osteoprotegerin (OPG) and receptor activator of the NF-κB liga…

Endocannabinoid Role in Synaptic Plasticity and Learning

2009

Endocannabinoids have recently emerged as versatile modulators of synaptic transmission and can act as retrograde neurotransmitters. As they cannot be stored in synaptic vesicles, endocannabinoid signaling is believed to start ‘on-demand,’ via a stimulus-dependent synthesis from membranous precursors at the postsynaptic site. After synthesis, endocannabinoids bind presynaptically to cannabinoid type 1 (CB1) receptors, leading to a short- or long-term suppression of neurotransmitter release. CB1 receptors are present in a plethora of different synaptic connections in the brain. Electrophysiological and behavioral analyses of mutant mice lacking CB1 receptors and of pharmacologically treated …

Ruvetkaasme, rohjetkaasme, älkääs ääntämme hävetkö : kansanmusiikkikerhon vaikutus Tolppilan koulun 1.-3. luokkalaisten asennoitumiseen suomalaista k…

2004

Mämminkosket

1897

Tuntematon päihde : sotilaiden päihteiden käyttö toisen maailmansodan aikana

2017

Tämä tutkielma käsittelee sotilaiden päihteiden käyttöä toisen maailmansodan aikana. Lähdeaineistona on käytetty muistelmateoksia sekä Kansa taisteli -lehden artikkeleita. Työssä on myös siteerattu sotaa käsittelevistä kaunokirjallisista teoksista Sotaromaania, Sissiluutnanttia ja Unohdettua sotilasta. Tarkastelu on tapahtunut sosiaalihistorian näkökulmasta hyödyntäen uuden sotilashistorian sekä muistihistorian näkökulmia. Päihteillä oli oma osansa toisessa maailmansodassa. Tämä tutkielma selvittää syitä miksi päihteitä käytettiin ja mihin tapahtumiin tai tapauksiin päihteiden käyttö liittyi. Käsiteltävät päihteet ovat alkoholi sekä huumeista morfiini, heroiini ja amfetamiinivalmiste Pervit…