Search results for "Ink"
showing 10 items of 4279 documents
An APOE haplotype associated with decreased ε4 expression increases the risk of late onset Alzheimer's disease.
2011
This paper addresses a tenet of the literature on APOE, i.e., the relationship between the effects of the e4, one of the established genetic risk factor for Alzheimer's disease (AD), and its expression levels as determined by APOE promoter polymorphisms. Five polymorphisms (-491 rs449647, -427 rs769446, -219 rs405509, and e rs429358-rs7412) were studied in 1308 AD patients and 1082 control individuals from the Central-Northern Italy. Major findings of the present study are the following: 1) the variants -219T and e4 increase the risk for late onset AD (LOAD) when they are both present in cis on the same chromosome (in phase); 2) the correlation between the haplotype (-219T/e4) and AD risk p…
Haptoglobin interacts with apolipoprotein E and beta-amyloid and influences their crosstalk.
2014
Beta-amyloid accumulation in brain is a driving force for Alzheimer's disease pathogenesis. Apolipoprotein E (ApoE) represents a critical player in beta-amyloid homeostasis, but its role in disease progression is controversial. We previously reported that the acute-phase protein haptoglobin binds ApoE and impairs its function in cholesterol homeostasis. The major aims of this study were to characterize the binding of haptoglobin to beta-amyloid, and to evaluate whether haptoglobin affects ApoE binding to beta-amyloid. Haptoglobin is here reported to form a complex with beta-amyloid as shown by immunoblotting experiments with purified proteins, or by its immunoprecipitation in brain tissues …
APOE epsilon variation in multiple sclerosis susceptibility and disease severity: some answers
2006
Background: Previous studies have examined the role of APOE variation in multiple sclerosis (MS), but have lacked the statistical power to detect modest genetic influences on risk and disease severity. The meta- and pooled analyses presented here utilize the largest collection, to date, of MS cases, controls, and families genotyped for the APOE epsilon polymorphism. Methods: Studies of MS and APOE were identified by searches of PubMed, Biosis, Web of Science, Cochrane Review, and Embase. When possible, authors were contacted for individual genotype data. Meta-analyses of MS case-control data and family-based analyses were performed to assess the association of APOE epsilon genotype with dis…
Neuronal cell cycle: the neuron itself and its circumstances.
2015
Neurons are usually regarded as postmitotic cells that undergo apoptosis in response to cell cycle reactivation. Nevertheless, recent evidence indicates the existence of a defined developmental program that induces DNA replication in specific populations of neurons, which remain in a tetraploid state for the rest of their adult life. Similarly, de novo neuronal tetraploidization has also been described in the adult brain as an early hallmark of neurodegeneration. The aim of this review is to integrate these recent developments in the context of cell cycle regulation and apoptotic cell death in neurons. We conclude that a variety of mechanisms exists in neuronal cells for G1/S and G2/M check…
Bifurcations of links of periodic orbits in non-singular Morse - Smale systems on
1997
The set of periodic orbits of a non-singular Morse - Smale (NMS) flow on defines a link; a characterization of all possible links of NMS flows on has been developed by Wada. In the frame of codimension-one bifurcations, this characterization allows us to study the restrictions a link requires for suffering a given bifurcation. We also derive the topological description of the new link and the possibility of relating links by a chain of this type of bifurcation.
Visible parts and dimensions
2003
We study the visible parts of subsets of n-dimensional Euclidean space: a point a of a compact set A is visible from an affine subspace K of n, if the line segment joining PK(a) to a only intersects A at a (here PK denotes projection onto K). The set of all such points visible from a given subspace K is called the visible part of A from K. We prove that if the Hausdorff dimension of a compact set is at most n−1, then the Hausdorff dimension of a visible part is almost surely equal to the Hausdorff dimension of the set. On the other hand, provided that the set has Hausdorff dimension larger than n−1, we have the almost sure lower bound n−1 for the Hausdorff dimensions of visible parts. We al…
One-dimensional families of projections
2008
Let m and n be integers with 0 < m < n. We consider the question of how much the Hausdorff dimension of a measure may decrease under typical orthogonal projections from onto m-planes provided that the dimension of the parameter space is one. We verify the best possible lower bound for the dimension drop and illustrate the sharpness of our results by examples. The question stems naturally from the study of measures which are invariant under the geodesic flow.
Mark-Houwink Parameters of Biosynthetic Poly(γ-glutamic acid) in Aqueous Solution
2001
A combined viscosity–light scattering–gel permeation chromatography (GPC) study was carried out on bacterially produced poly(γ-glutamic acid) (PGGA). PGGA samples with weight-average molecular weights ranging from 8×104 up to 8×105 g·mol–1 dissolved in phosphate buffer at 0.13 M ionic strength were used. It was found that the Mark–Houwink relation is acceptably obeyed, giving K and a values of 1.84×10–6 dL·g–1 and 1.16, respectively. As expected, GPC analysis showed that PGGA does not follow the universal calibration plot and that deviations can not be avoided by modifying the ionic strength.
Sources of geomaterials in the Sicani Mountains during the Early Middle Ages: A case study of Contrada Castro, central western Sicily
2022
From 2017, an unknown rural settlement in Contrada Castro at Corleone (Palermo Province, western Sicily) was investigated as part of the `Harvesting Memories Project¿. The stratigraphic sequence, supported by radiocarbon dating, has demonstrated a reoccupation of a pre-Roman site during the transition between the Byzantine and Islamic periods. In particular, the main occupation occurred in the late 8th¿9th century when pottery kilns and a probable warehouse were constructed. During the 10th¿11th century, a new structure with different orientations replaced the previous buildings that had already collapsed. Specifically focusing on a perspective of the household production and its relationsh…
Jatkosodan retoriikka : argumentaatioanalyysi pääministeri Rangellin ja pääministeri Linkomiehen puheista
2009
Tutkimuksen tehtävänä on selvittää, millaista retoriikkaa Suomen jatkosodan aikaiset pääministerit JW Rangell sekä Edwin Linkomies puheissaan käyttivät. Tarkastelen tutkimuskysymystä analysoimalla kaksi puhetta, joista toisen puheen piti Rangell syksyllä 1941. Toinen on Linkomiehen kesällä 1944 pitämä puhe. Analysoin puheet erittäin tarkasti käyttämällä metodina valtio-opin alalla yleistä argumentaatioanalyysia. Pääasiallisena teoreetikkona käytän Chaim Perelmanin retoriikkatutkimusta ja tukena myös Aristoteleen Retoriikka-teosta sekä uudempaa retoriikka- ja sotaretoriikkatutkimusta. Aineistona työssä ovat puheet, jotka ovat kokonaisuudessaan myös gradussa mukana. Tutkimus osoittaa, että su…