Search results for "Instability"
showing 10 items of 724 documents
In Vitro Assessment of the Genotoxic Hazard of Novel Hydroxamic Acid- and Benzamide-Type Histone Deacetylase Inhibitors (HDACi)
2020
Histone deacetylase inhibitors (HDACi) are already approved for the therapy of leukemias. Since they are also emerging candidate compounds for the treatment of non-malignant diseases, HDACi with a wide therapeutic window and low hazard potential are desirable. Here, we investigated a panel of 12 novel hydroxamic acid- and benzamide-type HDACi employing non-malignant V79 hamster cells as toxicology guideline-conform in vitro model. HDACi causing a &ge
Genomic instability induced by α-pinene in Chinese hamster cell line.
2012
Here, we report the effects of exposure of mammalian cells to α-pinene, a bicyclic monoterpene used in insecticides, solvents and perfumes. Morphological analysis, performed in V79-Cl3 cells exposed for 1 h to increasing concentrations (25 up to 50 μM) of α-pinene, indicated a statistically significant increase in micronucleated and multinucleated cell frequencies; apoptotic cells were seen at 40 and 50 μM. This monoterpene caused genomic instability by interfering with mitotic process; in fact, 50% of cells (versus 19% of control cells) showed irregular mitosis with multipolar or incorrectly localised spindles. Cytogenetic analysis demonstrated high-frequency hypodiploid metaphases as well…
Modulational instability and generation of self-induced transparency solitons in resonant optical fibers
2009
International audience; We consider continuous-wave propagation through a fiber doped with two-level resonant atoms, which is described by a system of nonlinear Schrodinger-Maxwell-Bloch (NLS-MB) equations. We identify the modulational instability (MI) conditions required for the generation of ultrashort pulses, in cases of both anomalous and normal GVD (group-velocity dispersion). It is shown that the self-induced transparency (SIT) induces non-conventional MI sidebands. The main result is a prediction of the existence of both bright and dark SIT solitons in the anomalous and normal GVD regimes.
Ultrasound measurement of detrusor thickness in bladder instability in women
1997
– Ultrasound was used to measure the detrusor thickness in 20 women with urodynamically-proved detrusorial instability. In 95% of the cases, detrusor thickness is greater than or equal to 5 mm. Comparison with a control group confirms the reliability of these results.
Environmental and ontogenetic constraints on developmental stability in the spatangoid sea urchin Echinocardium (Echinoidea).
2006
13 pages; International audience; Spatangoid irregular sea urchins are detritivorous benthic organisms particularly prone to variations of environment, and their mode of growth and plate morphology make them an appropriate model to assess the effects of environmental variations. Two populations of Echinocardium flavescens were sampled in two sites of the Norwegian coast characterized by contrasted environmental conditions. Different morphological descriptors (plate areas, interlandmarks distances, overall size, and shape of the posterior ambulacra) were used to appraise interindividual variations, and fluctuating asymmetry. The comparisons were carried out using classical fluctuating asymme…
Fluids of hard ellipsoids: Phase diagram including a nematic instability from Percus-Yevick theory
1999
An important aspect of molecular fluids is the relation between orientation and translation parts of the two-particle correlations. Especially the detailed knowledge of the influence of orientation correlations is needed to explain and calculate in detail the occurrence of a nematic phase. The simplest model system which shows both orientation and translation correlations is a system of hard ellipsoids. We investigate an isotropic fluid formed of hard ellipsoids with Percus-Yevick theory. Solving the Percus-Yevick equations self-consistently in the high density regime gives a clear criterion for a nematic instability. We calculate in detail the equilibrium phase diagram for a fluid of hard …
Instability of the faecal microbiota in diarrhoea-predominant irritable bowel syndrome
2013
The irritable bowel syndrome (IBS) is a functional gastrointestinal disorder with a largely unknown aetiology and a wide range of symptoms. Most cross-sectional studies carried out so far suggest subtle alterations in the structure of the intestinal microbiota that are barely reproduced, partly because of the high inter-subject variation in the community composition and disorder-specific features. We performed a longitudinal study to explore the within-subject variation in the faecal microbiota in two patients with IBS classified into the diarrhoea subtype and the healthy spouse of one of them. Faecal communities were monitored over 6-8 weeks and analysed through metagenomic and metatranscr…
Thermodynamic approach of supercontinuum generation
2009
International audience; This paper is aimed at providing an overview on recent theoretical and experimental works in which a thermodynamic description of the incoherent regime of supercontinuum generation has been formulated. On the basis of the wave turbulence theory, we show that this highly nonlinear and quasi-continuous-wave regime of supercontinuum generation is characterized by two different phenomena. (i) A process of optical wave thermalization ruled by the four-wave mixing effects: The spectral broadening inherent to supercontinuum generation is shown to result from the natural tendency of the optical field to reach its thermodynamic equilibrium state, i. e., the state of maximum n…
Pressure-induced phase transformation in zircon-type orthovanadate SmVO4from experiment and theory
2016
The compression behavior of zircon-type samarium orthovanadate, SmVO4, has been investigated using synchrotron-based powder x-ray diffraction and ab-initio calculations up to 21 GPa. The results indicate the instability of ambient zircon phase at around 6 GPa, which transforms to a high-density scheelite-type phase. The high-pressure phase remains stable up to 21 GPa, the highest pressure reached in the present investigations. On pressure release, the scheelite phase is recovered. Crystal structure of high-pressure phase and equations of state (EOS) for the zircon- and scheelite-type phases have been determined. Various compressibilities such as bulk, axial and bond, estimated from the expe…
The Instability of the NbTe2 Surface Structure
2002
Low energy electron diffraction from clean NbTe 2 surfaces shows very diffuse reflections. The effect is attributed to an anisotropic heating of the irradiated Te-Nb-Te surface layer. Diffraction patterns for electron energies below 90 eV correspond to an overlapped contribution from numerous domains, belonging to three orientational variants. Electrons of higher energies stabilize the parent high-temperature CdI 2 structure. A similar effect is observed during scanning tunneling microscopy, where the expected surface corrugation is usually lost for tunneling currents of a few ten nA.