Search results for "Instability"
showing 10 items of 724 documents
Irinotecan or oxaliplatin: Which is the first move for the mate?
2020
Objectives: The aim of the present review is to discuss the potential link between RAS, BRAF and microsatellite instability (MSI) mutational patterns and chemotherapeutic agent efficacy [Irinotecan (IRI) vs. Oxaliplatin (OXA)], and how this can potentially influence the choice of the chemotherapy backbone. Methods: Following a review of the research literature, all pertinent articles published in the core journals were selected for the study. The inclusion criteria regarded relevant clinical and pre-clinical studies on the topic of interest (Relationship of OXA and IRI to KRAS/BRAF mutations and MSI). Results: Excision repair cross complementation group 1 (ERCC1) expression is inhibited by…
Understanding the clinical behavior of relapsed colon cancers with microsatellite instability relative to BRAF mutations
2019
Background Microsatellite instable/deficient mismatch repair (MSI/dMMR) metastatic colorectal cancers have been reported to have a poor prognosis. Frequent co-occurrence of MSI/dMMR and BRAFV600E complicates the association. Patients and methods Patients with resected stage III colon cancer (CC) from seven adjuvant studies with available data for disease recurrence and MMR and BRAFV600E status were analyzed. The primary end point was survival after recurrence (SAR). Associations of markers with SAR were analyzed using Cox proportional hazards models adjusted for age, gender, performance status, T stage, N stage, primary tumor location, grade, KRAS status, and timing of recurrence. Results A…
The determinants of public deficit volatility
2009
This paper empirically analyzes the political, institutional and economic sources of public deficit volatility. Using the system-GMM estimator for linear dynamic panel data models and a sample of 125 countries analyzed from 1980 to 2006, we show that higher public deficit volatility is typically associated with higher levels of political instability and less democracy. In addition, public deficit volatility tends to be magnified for small countries, in the outcome of hyper-inflation episodes and for countries with a high degree of openness.
Double points in families of map germs from ℝ2 to ℝ3
2020
We show that a 1-parameter family of real analytic map germs [Formula: see text] with isolated instability is topologically trivial if it is excellent and the family of double point curves [Formula: see text] in [Formula: see text] is topologically trivial. In particular, we deduce that [Formula: see text] is topologically trivial when the Milnor number [Formula: see text] is constant.
Fold interaction and wavelength selection in 3D models of multilayer detachment folding
2014
Abstract Many fold-and-thrust belts are dominated by folding and exhibit a fairly regular fold-spacing. Yet, in map-view, the aspect ratio of doubly-plunging anticlines varies considerably from very elongated, and sometimes slightly curved, cylindrical folds to nearly circular, dome-like structures. In addition, the fold spacing often varies significantly around an average value. So far, it remains unclear whether these features are consistent with a folding instability. Therefore, we here study the dynamics of multilayer detachment folding, process by which shortening can be accommodated in thin-skinned fold-and-thrust belts. We start by analysing the physics of this process by using both …
Role of field losses on the Risken?Nummedal?Graham?Haken laser instability: application to erbium-doped fibre lasers
2003
We analyse the effect of both distributed and localised losses in a laser cavity on the Risken–Nummedal–Graham–Haken multimode instability. For two-level lasers, distributed losses are found to have a negligible influence on the instability conditions as long as they remain below 10 dB, a value hardly ever exceeded under common experimental conditions. If one keeps raising the distributed loss above that value, finally the uniform-field-limit results are recovered: localised loss becomes less and less important, and in the limit does not enter at all. In contrast, for three-level lasers – in particular for erbium-doped fibre lasers – distributed losses are found to have a profound quantitat…
Influence of pump coherence on the dynamic behavior of a laser
1988
The dynamic behavior of a coherently pumped single-mode unidirectional ring laser with a homogeneously broadened three-level active medium is studied. Our formulation is based on a set often real equations of the plane-wave, mean-field Maxwell–Bloch type. The instability domain in the main control parameters space is determined. Our numerical study of these equations for a parameter range of the type explored in the recent experiments by Weiss Brock [ Phys. Rev. Lett.57, 2804 ( 1986)] reveals some similarities, but striking differences between our theoretical predictions and their experimental observations are also noted.
Microgel regions in dilute agarose solutions: the notion of non-gelling concentration, and the role of spinodal demixing
1991
Abstract Freely drifting microgel regions are found in aqueous solutions of agarose, a representative biostructural polysaccharide, at concentrations between 0.01% and 0.05% w/v when quenched from 100°C to lower temperature. The size of these domains depends on the quench temperature and agarose concentration. The results agree with recent findings on the role that fluctuations within or close to the instability region of solution have as the initial step towards the self-assembly of supramolecular structures, and throw a new light on the notion of the lowest solute concentration needed for gelation.
Competition between intrinsic and extrinsic effects in the quenching of the superconducting state in FeSeTe thin films
2015
We report the first experimental observation of the quenching of the superconducting state in current-voltage characteristics of an iron-based superconductor, namely, in FeSeTe thin films. Based on available theoretical models, our analysis suggests the presence of an intrinsic flux-flow electronic instability along with non-negligible extrinsic thermal effects. The coexistence and competition of these two mechanisms classify the observed instability as halfway between those of low-temperature and of high-temperature superconductors, where thermal effects are respectively largely negligible or predominant.
X-ray emitting MHD accretion shocks in classical T Tauri stars. Case for moderate to high plasma-beta values
2009
AIMS. We investigate the stability and dynamics of accretion shocks in CTTSs, considering the case of beta >= 1 in the post-shock region. In these cases the 1D approximation is not valid and a multi-dimensional MHD approach is necessary. METHODS. We model an accretion stream propagating through the atmosphere of a CTTS and impacting onto its chromosphere, by performing 2D axisymmetric MHD simulations. The model takes into account the stellar magnetic field, the gravity, the radiative cooling, and the thermal conduction (including the effects of heat flux saturation). RESULTS. The dynamics and stability of the accretion shock strongly depends on the plasma beta. In the case of shocks with…