Search results for "Insula"
showing 10 items of 735 documents
The maternal genetic make-up of the Iberian Peninsula between the Neolithic and the Early Bronze Age
2017
Agriculture first reached the Iberian Peninsula around 5700 BCE. However, little is known about the genetic structure and changes of prehistoric populations in different geographic areas of Iberia. In our study, we focus on the maternal genetic makeup of the Neolithic (~ 5500–3000 BCE), Chalcolithic (~ 3000–2200 BCE) and Early Bronze Age (~ 2200–1500 BCE). We report ancient mitochondrial DNA results of 213 individuals (151 HVS-I sequences) from the northeast, central, southeast and southwest regions and thus on the largest archaeogenetic dataset from the Peninsula to date. Similar to other parts of Europe, we observe a discontinuity between hunter-gatherers and the first farmers of the Neol…
The Sea Urchin sns5 Chromatin Insulator Shapes the Chromatin Architecture of a Lentivirus Vector Integrated in the Mammalian Genome.
2016
Lentivirus vectors are presently the favorite vehicles for therapeutic gene transfer in hematopoietic cells. Nonetheless, these vectors integrate randomly throughout the genome, exhibiting variegation of transgene expression due to the spreading of heterochromatin into the vector sequences. Moreover, the cis-regulatory elements harbored by the vector could disturb the proper transcription of resident genes neighboring the integration site. The incorporation of chromatin insulators in flanking position to the transferred unit can alleviate both the above-mentioned dangerous effects, due to the insulator-specific barrier and enhancer-blocking activities. In this study, we report the valuable …
Surface structure promoted high-yield growth and magnetotransport properties of Bi2Se3 nanoribbons
2019
AbstractIn the present work, a catalyst-free physical vapour deposition method is used to synthesize high yield of Bi2Se3 nanoribbons. By replacing standard glass or quartz substrates with aluminium covered with ultrathin porous anodized aluminium oxide (AAO), the number of synthesized nanoribbons per unit area can be increased by 20–100 times. The mechanisms of formation and yield of the nanoribbons synthesized on AAO substrates having different arrangement and size of pores are analysed and discussed. It is shown that the yield and average length of the nanoribbons can base tuned by adjustment of the synthesis parameters. Analysis of magnetotransport measurements for the individual Bi2Se3…
Transcriptomic data from panarthropods shed new light on the evolution of insulator binding proteins in insects : Insect insulator proteins.
2016
Background Body plan development in multi-cellular organisms is largely determined by homeotic genes. Expression of homeotic genes, in turn, is partially regulated by insulator binding proteins (IBPs). While only a few enhancer blocking IBPs have been identified in vertebrates, the common fruit fly Drosophila melanogaster harbors at least twelve different enhancer blocking IBPs. We screened recently compiled insect transcriptomes from the 1KITE project and genomic and transcriptomic data from public databases, aiming to trace the origin of IBPs in insects and other arthropods. Results Our study shows that the last common ancestor of insects (Hexapoda) already possessed a substantial number …
Effect of graphene substrate type on formation of Bi2Se3 nanoplates
2019
AbstractKnowledge of nucleation and further growth of Bi2Se3 nanoplates on different substrates is crucial for obtaining ultrathin nanostructures and films of this material by physical vapour deposition technique. In this work, Bi2Se3 nanoplates were deposited under the same experimental conditions on different types of graphene substrates (as-transferred and post-annealed chemical vapour deposition grown monolayer graphene, monolayer graphene grown on silicon carbide substrate). Dimensions of the nanoplates deposited on graphene substrates were compared with the dimensions of the nanoplates deposited on mechanically exfoliated mica and highly ordered pyrolytic graphite flakes used as refer…
Alterations in White Matter Network and Microstructural Integrity Differentiate Parkinson’s Disease Patients and Healthy Subjects
2019
Parkinson’s disease (PD) is a neurodegenerative disease, neuropathologically characterized by progressive loss of neurons in distinct brain areas. We hypothesize that quantifiable network alterations are caused by neurodegeneration. The primary motivation of this study was to assess the specific network alterations in PD patients that are distinct but appear in conjunction with physiological aging. 178 subjects (130 females) stratified into PD patients, young, middle-aged and elderly healthy controls (age- and sex-matched with PD patients), were analyzed using 3D-T1 magnetization-prepared rapid gradient-echo (MPRAGE) and diffusion weighted images acquired in 3T MRI scanner. Diffusion modeli…
Survival of Late Pleistocene Hunter-Gatherer Ancestry in the Iberian Peninsula
2019
The Iberian Peninsula in southwestern Europe represents an important test case for the study of human population movements during prehistoric periods. During the Last Glacial Maximum (LGM), the peninsula formed a periglacial refugium [1] for hunter-gatherers (HGs) and thus served as a potential source for the re-peopling of northern latitudes [2]. The post-LGM genetic signature was previously described as a cline from Western HG (WHG) to Eastern HG (EHG), further shaped by later Holocene expansions from the Near East and the North Pontic steppes [3, 4, 5, 6, 7, 8, 9]. Western and central Europe were dominated by ancestry associated with the ∼14,000-year-old individual from Villabruna, Italy…
Uhlmann number in translational invariant systems
2019
We define the Uhlmann number as an extension of the Chern number, and we use this quantity to describe the topology of 2D translational invariant Fermionic systems at finite temperature. We consider two paradigmatic systems and we study the changes in their topology through the Uhlmann number. Through the linear response theory we linked two geometrical quantities of the system, the mean Uhlmann curvature and the Uhlmann number, to directly measurable physical quantities, i.e. the dynamical susceptibility and to the dynamical conductivity, respectively.
¿Una feria de cambios a la valenciana? Debate financiero y energía emprendedora en el siglo XVII
2020
In 1619 Philip IV sent to print a Real Pragmatic [Royal Pragmatic legislation] that would regulate changes between Valencia and Medina del Campo being introduced by Valencian merchant families to enable them to receive interest on their loans without being accused of usury. Only three years later, in 1622, the Republic of Genoa inaugurated the exchange fairs of Novi Ligure, with which the Genoese consolidated their international position in the international credit market. These apparently independent circumstances constitute an important episode for international financial knowledge and the transformation of the Mediterranean credit market during the seventeenth century. Studying financial…
The protection of environmentally displaced persons: Legal gaps in International and Regional Law
2022
La presente tesis tiene como objetivo principal identificar las lagunas que existen en el Derecho Internacional para proteger a las personas medioambientalmente desplazadas. El objeto de estudio de la investigación viene delimitado por el concepto de disrupción medioambiental, definida como un cambio drástico de origen natural en un ecosistema o en sus utilidades que lo hace, temporal o permanentemente, inhabitable para el ser humano. No se consideran, por tanto, las disrupciones de origen antrópico que pudieran obligar a la población a desplazarse, como la ejecución de un proyecto de desarrollo o los efectos de la guerra o la polución en el medio ambiente. La propia naturaleza de la disrup…