Search results for "Integrated Approach"
showing 10 items of 50 documents
Improving geoconservation of the palaeontological heritage through a semiotic vision
2019
The panoply of reasons that may attract people to fossils, which result from the meaning they attribute to these palaeontological objects, may contribute to endangering of the integrity of the fossil record. Semiotics can be of great help to assist geoconservation actions, usually based only on expertise statements, and are of particular relevance in palaeontological heritage inventory, evaluation, conservation, valuation and monitoring procedures. This work argues that fossils can be envisaged as signs displaying different meanings among experts and non-specialists. Such meanings support the heritage contents and values attributable to any palaeontological object and are affected by the re…
Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for …
2015
Background Up-to-date evidence on levels and trends for age-sex-specific all-cause and cause-specific mortality is essential for the formation of global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013) we estimated yearly deaths for 188 countries between 1990, and 2013. We used the results to assess whether there is epidemiological convergence across countries. Methods We estimated age-sex-specific all-cause mortality using the GBD 2010 methods with some refinements to improve accuracy applied to an updated database of vital registration, survey, and census data. We generally estimated cause of death as in the GBD 2010. Key improvements included…
Understanding aroma release from model cheeses by a statistical multiblock approach on oral processing
2013
For human beings, the mouth is the first organ to perceive food and the different signalling events associated to food breakdown. These events are very complex and as such, their description necessitates combining different data sets. This study proposed an integrated approach to understand the relative contribution of main food oral processing events involved in aroma release during cheese consumption. In vivo aroma release was monitored on forty eight subjects who were asked to eat four different model cheeses varying in fat content and firmness and flavoured with ethyl propanoate and nonan-2-one. A multiblock partial least square regression was performed to explain aroma release from the…
How to keep your staff healthy in the educational sector?
2021
The purpose of the paper is to identify risks and challenges for alternative forms of work during online classes for teaching personnel. Musculoskeletal disorders (MSD) affect the body’s bones, muscles, joints, ligaments/tendons, and nerves. Musculoskeletal health risk in the educational sector should be taken into consideration to ensure the safety and healthy employees, especially when online classes require a physical inactivity and a prolonged sitting in front of the computer. MSD management requires an integrated approach integrating wellbeing with a focus on prevention, recognizing physical, social and emotional influences and early intervention. Workplace wellness has been a valuable…
Large- and small-mammal distribution patterns and chronostratigraphic boundaries from the Late Pliocene to the Middle Pleistocene of the Italian peni…
2007
Abstract Over the last 50 years the studies on terrestrial mammals of the Italian peninsula have provided a large volume of data and a more detailed knowledge of faunal events during the Late Pliocene and Quaternary. Moreover geological, sedimentological, palynological and magnetostratigraphical investigations on the Pliocene–Pleistocene continental sedimentary basins have yielded the possibility of a detailed calibration of the faunal successions. Thus, palaeontologists have been able to reconstruct faunal sequences and to propose biochronological scales based on large and small mammals, respectively. In the present contribution an integration of the two biochronological scales is proposed…
Global, regional, national, and selected subnational levels of stillbirths, neonatal, infant, and under-5 mortality, 1980-2015 : a systematic analysi…
2016
BACKGROUND: Established in 2000, Millennium Development Goal 4 (MDG4) catalysed extraordinary political, financial, and social commitments to reduce under-5 mortality by two-thirds between 1990 and 2015. At the country level, the pace of progress in improving child survival has varied markedly, highlighting a crucial need to further examine potential drivers of accelerated or slowed decreases in child mortality. The Global Burden of Disease 2015 Study (GBD 2015) provides an analytical framework to comprehensively assess these trends for under-5 mortality, age-specific and cause-specific mortality among children under 5 years, and stillbirths by geography over time. METHODS: Drawing from ana…
Groundwater Safety by Monitoring Quality Parameters in Transylvania, Romania
2021
This chapter presents the safety of groundwater in Transylvania, Romania by monitoring quality parameters. At first, presents the aspects regarding the importance of groundwater for humankind, the underground water being regarded as a natural, untreated and free source. Drinking water is used in human food that meets a number of physicochemical and microbiological conditions that allow consumption without endangering health. The case study is carried out in a Romanian region (Alba County—Transylvania), the main appreciation indicators of the underground water sources quality being monitored over time. Concentration/pollution levels were determined by physicochemical and microbiological anal…
An Importance-Performance Matrix Analysis of the Factors Influencing US Tourists to Use Airbnb
2019
After 10 years of Airbnb and its significant growth, this research is conducted to identify which factors really matter to Airbnb users today. It provides an integrated approach, since it aggregates factors that other studies have considered separately. With a sample of 101 US respondents, the partial least squares structural equation modelling results evidence that the only factors that influence future intentions to use Airbnb are its unique and varied accommodations and satisfaction. Enjoyment was also found to have a positive effect on Satisfaction. The study further investigates these factors with an Importance Performance map, providing guidance for the prioritization of managerial ac…
Un modello operativo per il trattamento degli esordi di schizofrenia
2011
Riassunto Introduzione Studi recenti mostrano un aumento dei disturbi psicotici in fase giovanile con prognosi peggiore rispetto alle forme tardive. Il presente lavoro intende valutare i potenziali benefici dell’intervento integrato precoce sugli outcome globali. Scopo dello studio Si e presa in esame l’organizzazione dei servizi nella citta di Palermo, rispetto alla quale sono da evidenziare l’integrazione degli interventi dell’UO di Psichiatria dell’Azienda Ospedaliera Universitaria Policlinico e del Dipartimento di Salute Mentale, l’integrazione degli interventi tra personale del Servizio di Neuropsichiatria dell’Infanzia dell’Azienda Sanitaria Provinciale e dell’Unita Operativa di Riabi…
Discovery of γ-secretase modulators with a novel activity profile by text-based virtual screening.
2012
We present an integrated approach to identify and optimize a novel class of γ-secretase modulators (GSMs) with a unique pharmacological profile. Our strategy included (i) virtual screening through application of a recently developed protocol (PhAST), (ii) synthetic chemistry to discover structure–activity relationships, and (iii) detailed in vitro pharmacological characterization. GSMs are promising agents for treatment or prevention of Alzheimer’s disease. They modulate the γ-secretase product spectrum (i.e., amyloid-β (Aβ) peptides of different length) and induce a shift from toxic Aβ42 to shorter Aβ species such as Aβ38 with no or minimal effect on the overall rate of γ-secretase cleavag…