Search results for "Interaction"
showing 10 items of 5710 documents
HSV-1 Glycoprotein D and Its Surface Receptors: Evaluation of Protein–Protein Interaction and Targeting by Triazole-Based Compounds through In Silico…
2023
Protein–protein interactions (PPI) represent attractive targets for drug design. Thus, aiming at a deeper insight into the HSV-1 envelope glycoprotein D (gD), protein–protein docking and dynamic simulations of gD-HVEM and gD-Nectin-1 complexes were performed. The most stable complexes and the pivotal key residues useful for gD to anchor human receptors were identified and used as starting points for a structure-based virtual screening on a library of both synthetic and designed 1,2,3-triazole-based compounds. Their binding properties versus gD interface with HVEM and Nectin-1 along with their structure-activity relationships (SARs) were evaluated. Four [1,2,3]triazolo[4,5-b]pyridines were i…
Research data supporting "Social information use about novel aposematic prey is not influenced by a predator’s previous experience with toxins"
2019
This data is from the experiment investigating social avoidance learning in wild-caught great tits, conducted at Konnevesi Research Station in Central Finland during winter 2017. Sheet 1 (���main data���) contains data from the main avoidance learning experiment, including individual attributes (sex, age, weight etc.), experimental treatments and individuals��� foraging choices in the learning trials. Sheet 2 (���preference test���) contains data from the initial preference test of the symbols that were used in the experiment, and Sheet 3 (���visibility test���) data from the initial visibility test of the same symbols.
Interactions of virus proteins within the host cell
2014
Ventilative cooling application in Mediterranean buildings: impacts on grid interaction and load match
2016
The concept of load matching refers to the simultaneous occurrence of loads and generation in buildings: it can be increased and optimised with modifications on both the energy demand and generation, but its pre-requisite is to guarantee passive energy efficiency. In the Mediterranean areas, a major challenge in new buildings is the increasing overheating even during mildly hot seasons. Ventilative cooling can be a potential solution to such issues and have an impact on load match in buildings and their grid interaction. The study analyses the potential of ventilative cooling to improve the load match in three different case studies in Italy. Ventilative cooling proved viable in moderately …
Many-body Green's function theory for electron-phonon interactions: ground state properties of the Holstein dimer
2015
We study ground-state properties of a two-site, two-electron Holstein model describing two molecules coupled indirectly via electron-phonon interaction by using both exact diagonalization and self-consistent diagrammatic many-body perturbation theory. The Hartree and self-consistent Born approximations used in the present work are studied at different levels of self-consistency. The governing equations are shown to exhibit multiple solutions when the electron-phonon interaction is sufficiently strong whereas at smaller interactions only a single solution is found. The additional solutions at larger electron-phonon couplings correspond to symmetry-broken states with inhomogeneous electron de…
Understanding the challenges of rapid digital transformation : the case of COVID-19 pandemic in higher education
2021
Rapid digital transformation is taking place due to the COVID-19 pandemic, forcing organisations and higher educational institutions to change their working and learning culture. This study explores the challenges of rapid digital transformation arising during the pandemic in the higher education context. This research used the Q-methodology to understand the nine challenges that higher education encountered, perceived differently as four main patterns: (1) Digital-nomad enterprise; (2) Corporate-collectivism; (3) Well-being-oriented; and (4) Pluralistic. This study broadens the current understanding of digital transformation, especially in higher education. The nine challenges and four pat…
AI ethics:an empirical study on the views of practitioners and lawmakers
2023
Artificial intelligence (AI) solutions and technologies are being increasingly adopted in smart systems contexts; however, such technologies are concerned with ethical uncertainties. Various guidelines, principles, and regulatory frameworks are designed to ensure that AI technologies adhere to ethical well-being. However, the implications of AI ethics principles and guidelines are still being debated. To further explore the significance of AI ethics principles and relevant challenges, we conducted a survey of 99 randomly selected representative AI practitioners and lawmakers (e.g., AI engineers and lawyers) from 20 countries across five continents. To the best of our knowledge, this is the …
Barriers and wellbeing-oriented enablers of intergenerational innovation in the digital age
2021
AbstractSo far, researchers have used a wellbeing-centered approach to catalyze successful intergenerational collaboration (IGC) in innovative activities. However, due to the subject’s multidisciplinary nature, there is still a dearth of comprehensive research devoted to constructing the IGC system. Thus, the purpose of this study is to fill a research void by providing a conceptual framework for information technology (IT) system designers to use as a jumping-off point for designing an IGC system with a wellbeing-oriented design. A systematic literature study was conducted to identify relevant terms and develop a conceptual framework based on a review of 75 selected scientific papers. The …
Halogen Bonds in Square Planar 2,5-Dihalopyridine-Copper(II) Bromide Complexes
2018
The impact of wildlife and environmental factors on hantavirus infection in the host and its translation into human risk
2023
Identifying factors that drive infection dynamics in reservoir host populations is essential in understanding human risk from wildlife-originated zoonoses. We studied zoonotic Puumala orthohantavirus (PUUV) in the host, the bank vole ( Myodes glareolus ), populations in relation to the host population, rodent and predator community and environment-related factors and whether these processes are translated into human infection incidence. We used 5-year rodent trapping and bank vole PUUV serology data collected from 30 sites located in 24 municipalities in Finland. We found that PUUV seroprevalence in the host was negatively associated with the abundance of red foxes, but this process did no…