Search results for "Interaction"
showing 10 items of 5710 documents
The Interaction Mechanism of Intrinsically Disordered PP2A Inhibitor Proteins ARPP-16 and ARPP-19 With PP2A
2021
Protein phosphatase 2A (PP2A) activity is critical for maintaining normal physiological cellular functions. PP2A is inhibited by endogenous inhibitor proteins in several pathological conditions including cancer. A PP2A inhibitor protein, ARPP-19, has recently been connected to several human cancer types. Accordingly, the knowledge about ARPP-19—PP2A inhibition mechanism is crucial for the understanding the disease development and the therapeutic targeting of ARPP-19—PP2A. Here, we show the first structural characterization of ARPP-19, and its splice variant ARPP-16 using NMR spectroscopy, and SAXS. The results reveal that both ARPP proteins are intrinsically disordered but contain transient…
Three-dimensional bimetallic octacyanidometalates $[M^{IV}{(\mu-CN)_{4}Mn^{II}(H_{2}O)_2}_2 \cdot 4H_{2}O]_{n}$ (M=Nb,Mo,W) : synthesis, single-cryst…
2008
Abstract We report the synthesis, the single-crystal X-ray crystallographic structures and the magnetic properties of three new isostructural cyanido-bridged networks: [M IV {(μ-CN) 4 Mn II (H 2 O) 2 } 2 ·4H 2 O] n [M IV = Nb IV ( 1 ), Mo IV ( 2 ), W IV ( 3 )]. For compound 1 , the magnetic properties reveal a ferrimagnetic phase below 50 K. In contrast, compounds 2 and 3 show a paramagnetic behaviour with no magnetic ordering down to 2 K. The only electronic difference between the two kinds of compounds is the presence of two paired electrons on Mo IV ( 2 ) and W IV ( 3 ) (d 2 electronic configuration, S = 0) with no possible exchange interactions with Mn II ions (d 5 electronic configur…
New Capabilities of the FLUKA Multi-Purpose Code
2022
We would like to deeply thank the CERN Knowledge Transfer and Legal Service teams for their essential and extended support. Our appreciation also goes to the FLUKA.CERN Collaboration Board members for their strong commitment.
Do large‐scale associations in birds imply biotic interactions or environmental filtering?
2023
Aim There has been a wide interest in the effect of biotic interactions on species' occurrences and abundances at large spatial scales, coupled with a vast development of the statistical methods to study them. Still, evidence for whether the effects of within-trophic-level biotic interactions (e.g. competition and heterospecific attraction) are discernible beyond local scales remains inconsistent. Here, we present a novel hypothesis-testing framework based on joint dynamic species distribution models and functional trait similarity to dissect between environmental filtering and biotic interactions. Location France and Finland. Taxon Birds. Methods We estimated species-to-species association…
gllvm : Fast analysis of multivariate abundance data with generalized linear latent variable models in R
2019
1.There has been rapid development in tools for multivariate analysis based on fully specified statistical models or “joint models”. One approach attracting a lot of attention is generalized linear latent variable models (GLLVMs). However, software for fitting these models is typically slow and not practical for large datsets. 2.The R package gllvm offers relatively fast methods to fit GLLVMs via maximum likelihood, along with tools for model checking, visualization and inference. 3.The main advantage of the package over other implementations is speed e.g. being two orders of magnitude faster, and capable of handling thousands of response variables. These advances come from using variationa…
Il web per la cultura. Dalla digital identity alla progettazione dei servizi in rete.
2006
Negli ultimi decenni è in atto una trasformazione nell’ambito dei beni culturali definibile come un processo di apertura dei luoghi della cultura (musei, siti archeologici, biblioteche, etc.) verso l’esterno, determinato dalle istituzioni stesse, con il loro differente modo di intendere la conservazione e di gestire la fruizione del patrimonio storico-artistico e dal sistema dei fruitori, con la loro diversa domanda del prodotto culturale, che si svolge in tempi e modi differenti rispetto al passato. D’altra parte, gli studiosi della cybercultura segnalano che il nostro tempo, con l’incalzante introduzione di nuove tecnologie e strumenti, apparterrebbe in realtà solo agli albori di una rivo…
Musical interaction in music therapy for depression treatment
2022
Music therapy is efficacious for the treatment of depression. Compared to other psychotherapeutic forms, it allows for the emergence of various modes of mutual interaction, thus enabling multiple channels for emotional expression and fostering therapeutic alliance. Although musical interaction patterns between client and therapist have been regarded as predictors of therapeutic outcome in depression, this has not yet been systematically investigated. We aim to address this gap by analyzing the possible linkage between musical interaction features and changes in depression score. In a clinical trial, digital piano improvisations from 58 Finnish clients and their therapists were recorded ove…
Self-Complementary Dimers of Oxalamide-Functionalized Resorcinarene Tetrabenzoxazines
2018
Self‐complementarity is a useful concept in supramolecular chemistry, molecular biology and polymeric systems. Two resorcinarene tetrabenzoxazines decorated with four oxalamide groups were synthesized and characterized. The oxalamide groups possessed self‐complementary hydrogen bonding sites between the carbonyls and amide groups. The self‐complementary nature of the oxalamide groups resulted in self‐included dimeric assemblies. The hydrogen bonding interactions within the tetrabenzoxazines gave rise to the formation of dimers, which were confirmed by single‐crystal X‐ray diffractions analysis and supported by NMR spectroscopy and mass spectrometry. The self‐included dimers were connected b…
Reflections on dialogicity : Challenges and suggestions by mathematics student teachers
2021
Research related to dialogic teaching has been gaining ground in recent decades. On a theoretical level, researchers have described how sociocultural approaches are linked to dialogic teaching. In addition, empirical studies have explained how dialogic teaching manifests itself in educational dialogue and classroom interactions. However, studies addressing how the dialogic theory and practice could be linked meaningfully in teacher education and professional development programs in subject teacher education and related praxis are still limited. Especially in the case of math teacher education, the reported professional development programs are limited in number. Whereas the tendency has bee…
Students' dialogic and justifying moves during dialogic argumentation in mathematics and physics
2022
In this study, we focus on dialogic argumentation among students in a whole class setting in mathematics and physics in lower secondary school. By drawing on previous studies on the structure of argumentation and dialogic interactions, we suggest that transparency of student reasoning and students' engagement with each other's ideas are two key aspects in dialogic argumentation. We examine what levels might exist in these key aspects and how they can exist simultaneously. We collected data by video recording mathematics and physics lessons in lower secondary school, and created a coding scheme for students' dialogic and justifying moves. By using the coding scheme, we recognized different k…