Search results for "Interactions"
showing 10 items of 1963 documents
Fine-tuning lexical bundles : a methodological reflection in the context of describing drug-drug interactions
2018
This chapter has two major aims. First, it attempts to extend earlier research on recurrent phraseologies used in the pharmaceutical field (Grabowski 2015) by exploring the use, distribution and functions of lexical bundles found in English texts describing drug-drug interactions. Conducted from an applied perspective, the study uses 300 text samples extracted from DrugDDI Corpus originally collected in the Drugbank database (Segura-Bedmar et al. 2010). Apart from presenting new descriptive data, the second aim of the chapter is to reflect on the ways lexical bundles have been typically explored across different text types and genres. The problems discussed in the chapter concern the method…
Strategies for Exploring Functions from Dynamic Combinatorial Libraries
2020
Dynamic combinatorial chemistry (DCC) is a powerful approach for creating complex chemical systems, giving access to the studies of complexity and exploration of functionality in synthetic systems. However, compared with more advanced living systems, the man‐made chemical systems are still less functional, due to their limited complexity and insufficient kinetic control. Here we start by introducing strategies to enrich the complexity of dynamic combinatorial libraries (DCLs) for exploiting unexpected functions by increasing the species of building blocks and/or templates used. Then, we discuss how dynamic isomerization of photo‐switchable molecules help DCLs increase and alter the systemic…
Population structure of a parasitic plant and its perennial host
2002
Characterization of host and parasite population genetic structure and estimation of gene flow among populations are essential for the understanding of parasite local adaptation and coevolutionary interactions between hosts and parasites. We examined two aspects of population structure in a parasitic plant, the greater dodder (Cuscuta europaea) and its host plant, the stinging nettle (Urtica dioica), using allozyme data from 12 host and eight parasite populations. First, we examined whether hosts exposed to parasitism in the past contain higher levels of genetic variation. Second, we examined whether host and parasite populations differ in terms of population structure and if their populati…
Differences in parasite susceptibility and costs of resistance between naturally exposed and unexposed host populations
2009
It is generally assumed that resistance to parasitism entails costs. Consequently, hosts evolving in the absence of parasites are predicted to invest less in costly resistance mechanisms than hosts consistently exposed to parasites. This prediction has, however, rarely been tested in natural populations. We studied the susceptibility of three naïve, three parasitized and one recently isolated Asellus aquaticus isopod populations to an acanthocephalan parasite. We found that parasitized populations, with the exception of the isopod population sympatric with the parasite strain used, were less susceptible to the parasite than the naïve populations. Exposed but uninfected (resistant) isopods f…
Chalcogen‐Bonding Interactions in Telluroether Heterocycles [Te(CH2)m]n (n=1-4; m=3-7)
2020
The Te…Te secondary bonding interactions (SBI) in solid heterocyclic telluroethers were explored by preparing and structurally characterizing a series of [Te(CH2)m]n (n = 1‐4; m = 3‐7) species. The SBIs in 1,7‐Te2(CH2)10, 1,8‐Te2(CH2)12, 1,5,9‐Te3(CH2)9, 1,8,15‐Te3(CH2)18, 1,7,13,19‐Te4(CH2)20, 1,8,15,22‐Te4(CH2)24, and 1,9,17,25‐Te4(CH2)28 led to the tubular packing of the molecules, as has been observed previously for related thio‐ and selenoether rings. The nature of the intermolecular interactions was explored by solid‐state PBE0‐D3/pob‐TZVP calculations involving periodic boundary conditions. The packing of molecules in 1,7,13,19‐Te4(CH2)20, 1,8,15,22‐Te4(CH2)24, and 1,9,17,25‐Te4(CH2)…
Synergistic and Redundant Brain-Heart Information in Patients with Focal Epilepsy
2020
In this work, partial information decomposition (PID) was applied to the time series of heart rate and EEG amplitude variability to investigate the dynamical interactions in brain-heart coupling before and after epileptic seizures. From ECG and EEG signals collected on 23 children suffering from focal epilepsy, the RR intervals and the EEG variance at ipsilateral and contralateral temporal electrodes were computed in four different time windows before and after the seizures. Static PID was used to obtain redundant, unique and synergistic components of the total information shared between the series of RR and EEG variance. Results highlight, in the progression from preictal to postictal stat…
NuSTEC White Paper: Status and challenges of neutrino–nucleus scattering
2018
International audience; The precise measurement of neutrino properties is among the highest priorities in fundamental particle physics, involving many experiments worldwide. Since the experiments rely on the interactions of neutrinos with bound nucleons inside atomic nuclei, the planned advances in the scope and precision of these experiments require a commensurate effort in the understanding and modeling of the hadronic and nuclear physics of these interactions, which is incorporated as a nuclear model in neutrino event generators. This model is essential to every phase of experimental analyses and its theoretical uncertainties play an important role in interpreting every result.In this Wh…
ELECTRON SPIN RELAXATION PROCESS IN SILICON CRYSTALS
2014
Recently, electrical injection of spin polarization in n-type and p-type silicon has been experimentally carried out up to room-temperature. Despite of these preliminary but promising experimental results, a comprehensive theoretical framework concerning the influence of transport conditions on the phonon-induced spin depolarization process in silicon structures, in a wide range of values of temperature, doping concentration and amplitude of external fields, is still in a developing stage. In order to elucidate the electron transport and spin dynamics of conduction electrons in lightly doped n-type Si crystals we have performed semiclassical multiparticle Monte Carlo simulations and numeric…
Monte Carlo Simulation of Spin Relaxation of Conduction Electrons in Silicon
2014
Recently, electrical injection of spin polarization in n-type and p-type silicon up to room-temperature has been experimental- ly carried out. Despite of these promising experimental results, a comprehensive theoretical framework concerning the influence of transport conditions on the spin depolarization process in silicon structures, in a wide range of values of temperature, doping concentration and amplitude of external fields, is still in a developing stage. In this contribution we use a semiclassical multiparti- cle Monte Carlo approach to simulate the electron transport and spin dynamics in lightly doped n-type Si crystals and numerically calculate the spin lifetimes of drifting electr…
Muon-electron lepton-flavor-violating transitions : Shell-model calculations of transitions in 27Al
2018
In this paper we present the results of large-scale shell-model calculations of muon-to-electron lepton-flavorviolating transitions for the case of the target nucleus 27Al. We extend the previous shell-model calculations, done in the sd model space, by including also the p orbitals in order to see whether the negative-parity states produce any significant effect in the conversion rate. The analysis of the results shows the dominance of coherent transitions mediated by isovector operators and going by the ground state of the target, with practically null influence of excited positive- or negative-parity states. peerReviewed