Search results for "Interconnectivity"
showing 4 items of 4 documents
Bioelectrical coupling in multicellular domains regulated by gap junctions: A conceptual approach.
2018
We review the basic concepts involved in bioelectrically-coupled multicellular domains, focusing on the role of membrane potentials (Vmem). In the first model, single-cell Vmem is modulated by two generic polarizing and depolarizing ion channels, while intercellular coupling is implemented via voltage-gated gap junctions. Biochemical and bioelectrical signals are integrated via a feedback loop between Vmem and the transcription and translation of a protein forming an ion channel. The effective rate constants depend on the single-cell Vmem because these potentials modulate the local concentrations of signaling molecules and ions. This electrochemically-based idealization of the complex bioph…
Disaster Prevention Integrated into Commonly Used Web Rendered Systems with GIS Capabilities
2014
The end of the 20th century brought a remarkable increase in the field of positioning techniques and communications, making them visible and available to the public, which led to an unprecedented interconnectivity. At the same time, disasters are part of our life. Regardless of their nature, measures can be taken, in order to prevent and mitigate their effects, by anticipative preparation or by avoiding the calamity area (if possible). To this end, this paper presents an integrated system, composed of a software component, a hardware component, and a decision-making human element, all having the declared role of diminishing or eliminating human and material losses.
Covalent RGD modification of the inner pore surface of polycaprolactone scaffolds
2011
Scaffold production for tissue engineering was demonstrated by means of a hot compression molding technique and subsequent particulate leaching. The utilization of spherical salt particles as the pore-forming agent ensured complete interconnectivity of the porous structure. This method obviated the use of potentially toxic organic solvents. To overcome the inherent non-cell-adhesive properties of the hydrophobic polymer polycaprolactone (PCL) surface activation with a diamine was performed, followed by the covalent immobilization of the adhesion-promoting RGD-peptide. The wet-chemical approach was performed to guarantee modification throughout the entire scaffold structure. The treatment wa…
Inorganic Polymers: Morphogenic Inorganic Biopolymers for Rapid Prototyping Chain
2013
In recent years, considerable progress has been achieved towards the development of customized scaffold materials, in particular for bone tissue engineering and repair, by the introduction of rapid prototyping or solid freeform fabrication techniques. These new fabrication techniques allow to overcome many problems associated with conventional bone implants, such as inadequate external morphology and internal architecture, porosity and interconnectivity, and low reproducibility. However, the applicability of these new techniques is still hampered by the fact that high processing temperature or a postsintering is often required to increase the mechanical stability of the generated scaffold, …