Search results for "Internal validity"
showing 10 items of 16 documents
Systematic review of guidelines for internal validity in the design, conduct and analysis of preclinical biomedical experiments involving laboratory …
2020
Over the last two decades, awareness of the negative repercussions of flaws in the planning, conduct and reporting of preclinical research involving experimental animals has been growing. Several initiatives have set out to increase transparency and internal validity of preclinical studies, mostly publishing expert consensus and experience. While many of the points raised in these various guidelines are identical or similar, they differ in detail and rigour. Most of them focus on reporting, only few of them cover the planning and conduct of studies. The aim of this systematic review is to identify existing experimental design, conduct, analysis and reporting guidelines relating to preclinic…
Protocol for a systematic review of guidelines for rigour in the design, conduct and analysis of biomedical experiments involving laboratory animals
2018
Objective Within the last years, there has been growing awareness of the negative repercussions of unstandardized planning, conduct and reporting of preclinical and biomedical research. Several initiatives have set the aim of increasing validity and reliability in reporting of studies and publications, and publishers have formed similar groups. Additionally, several groups of experts across the biomedical spectrum have published experience and opinion-based guidelines and guidance on potential standardized reporting. While all these guidelines cover reporting of experiments, an important step prior to this should be rigours planning and conduction of studies. The aim of this systematic revi…
Subclinical thought disorder in first-degree relatives of schizophrenic patients. Results from a matched-pairs study with the Thought Disorder Index
1995
To assess the frequency and quality of formal thought disorder in schizophrenic patients and their first-degree relatives, a consecutive series of 36 unmedicated patients, 20 siblings of these patients and 37 normal control subjects were examined with Holzman's Thought Disorder Index (TDI). As a proof of the internal validity of this tool, the patients demonstrated significantly more thought disorder than the controls as measured by the TDI total score and various subscores, which proved the internal validity of this tool in a German-speaking sample. In addition, in a pairwise comparison with controls who were individually matched by age and sex the patients' siblings had a significantly hi…
Quality of Life in Individuals Affected by Arnold Chiari Malformation: Comparison and Validation of a Measurement Instrument.
2017
BACKGROUND Introduction. Arnold Chiari Malformation (ACM) type I is a pathology whose symptomatology has repercussions for the quality of life of those affected by it. Quality-of-life measurement instruments can allow the severity of the impact of Chiari type I malformation on patients' lives to be monitored. The Chiari Symptom Profile (CSP) is a valid and reliable instrument designed for this purpose. The aim of the study was to adapt the CSP to Spanish and to explore the reliability and validity of this construct in the context of Spanish-speaking patients with ACM. METHODS The English CSP instrument has a good internal validity and consistency. We used a standardized procedure for the li…
The effect of exposure to radiofrequency fields on cancer risk in the general and working population: A protocol for a systematic review of human obs…
2021
Highlights • RF-EMF was classified by IARC as possibly carcinogenic to humans (2B) in May 2011 • A systematic review of all subject-relevant epidemiological studies is now needed. • A detailed protocol ensures the review's transparency, utility and credibility. • Original study validity will be evaluated with a customized OHAT risk of bias tool. • Internal coherence and external plausibility will inform conclusions.
All Student Samples Differ: On Participant Selection in Communication Science
2012
When conducting experiments, researchers in communication science often rely on convenience samples of students. This study provides evidence consistent with a concern that between-participant differences in exposure to communication theories can be a threat to the internal validity of conclusions reached. Using cultivation theory as a context for studying this threat, this study examines the influence of stage in university education and discipline of study on the ability to detect the cultivation hypothesis and participants' responses to questions regularly used in studies of cultivation. We found that university students at different stages of their studies and studying different discipl…
Methodological considerations for interrupted time series analysis in radiation epidemiology: an overview
2021
Interrupted time series analysis (ITSA) is a method that can be applied to evaluate health outcomes in populations exposed to ionizing radiation following major radiological events. Using aggregated time series data, ITSA evaluates whether the time trend of a health indicator shows a change associated with the radiological event. That is, ITSA checks whether there is a statistically significant discrepancy between the projection of a pre-event trend and the data empirically observed after the event. Conducting ITSA requires one to consider specific methodological issues due to unique threats to internal validity that make ITSA prone to bias. We here discuss the strengths and limitations of …
A Critical Review Of The Hardiness Scales
2018
INTRODUCTION: The construct of hardiness - structured in the control, commitment and challenge components - is a personality variable that allows individuals to respond effectively to stress demands, to perform better and to stay healthier. Individuals with high scores on these three factors show less powerlessness and alienation, interpret life events as controllable, interesting and as growth opportunities. Although in the last forty years many scholars had contributed to consolidate the hardiness theoretical framework, a substantial critical issue emerges with regard to the large heterogeneity of the scales used to measure hardiness. OBJECTIVE: The main aim of the study is to conduct a c…
Assessing natural metalinguistic skills in people with Alzheimer’s disease and frontotemporal dementia
2019
Abstract Objective The aim of this paper is to assess whether the use of natural metalinguistic skills can be used to differentiate linguistic-communicative profiles of people with dementia (Alzheimer’s disease and frontotemporal dementia in the behavioural and primary progressive aphasia variants) in the earliest stages of the disease. Method A sample of 180 people was selected. Sixty had Alzheimer’s disease, 20 had frontotemporal dementia of the behavioural variant, and 40 had frontotemporal dementia of the primary progressive aphasia variant (20 had non-fluent primary progressive aphasia and 20 had semantic dementia). The control group was composed of 60 healthy people with ages, gender,…
Perception of Dating Violence in Teenage Couples: A Cross Validation Study in Spain and Colombia
2020
Background: dating violence, or violence in teenage couples, is a socially interesting topic, due to its prevalence and its possible use in predicting violence in adult couples. The perception of violence, or the detection of abusive behaviors by teenagers and young people (which can be considered as equivalent concepts), is essential to prevent violence itself. Therefore, the main objective of this research is to determine which behaviors are identified as abusive by teenagers and young people, and the severity that they attribute to them&mdash