Search results for "Intervertebral disc"
showing 10 items of 66 documents
Pro-inflammatory, Pleiotropic, and Anti-inflammatory TNF-α, IL-6, and IL-10 in Experimental Porcine Intervertebral Disk Degeneration
2009
The aim of this study was to check the balance between tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-10 (IL-10) in well-developed end-stage disk disease in the disk itself as well as in paradiskal spine. In 6 domestic pigs the cranial bony end plate of the L4 vertebra was perforated to the nucleus pulposus. At 3 months the degenerated experimental and contiguous control disks, together with the adjoining bony and cartilaginous vertebral end plates, bone marrow, and spinal ligaments, were excised and used for immunohistochemical analysis. In general, there were more TNF-α and in particular IL-10 positive cells in the degenerated disks than in the control disks, where…
Modic changes-Their associations with low back pain and activity limitation: A systematic literature review and meta-analysis.
2018
Background Previous systematic reviews have reported positive associations between Modic changes (MCs) and low back pain (LBP), but due to their narrow scope and new primary studies, there is a need for a comprehensive systematic review. Our objectives were to investigate if MCs are associated with non-specific LBP and/or activity limitation and if such associations are modified by other factors. Methods A protocol for this review was registered at PROSPERO prior to commencing the work (PROSPERO record: CRD42015017350). The MEDLINE, CINAHL and EMBASE databases were searched for relevant studies from first record to June 15th 2016. Prospective or retrospective cross-sectional cohort studies …
Reoperations After First Lumbar Disk Herniation Surgery with or without Implantation of Mechanical Annular Closure Device
2019
Lumbar diskectomy is a widely performed surgical procedure in patients affected by lumbar disk herniation (LDH). Such a surgical procedure is considered to be safe and able to provide a consistent symptomatic relief in most patients. However, perioperative complications have been reported, ranging from 13% to 15%, and pose a considerable financial burden among patients, hospitals, and national health care agencies. The most common perioperative complication following lumbar diskectomy for disk herniation is the recurrence. Although the recurrence rate of LDH has been reported to be 5%−15%, its exact incidence may be underestimated. Recurrent lumbar disk herniation (rLDH) is defined as disk …
Fractional Calculus as a New Perspective in the Viscoelastic Behaviour of the Intervertebral Disc
2022
The spinal column is the load-bearing structure of the human being along with its components, which together build a strong, resistant, and stable structure, but there are a few different pathologies from which it can suffer, such as herniated discs. The intervertebral disc acts as a shock absorber and ensures the spine’s great capacity to support high loads and different states of stress, thanks to its viscoelastic properties. Some studies have attempted to describe the viscoelastic behaviour of the intervertebral disc using classical rheological models, such as the Kelvin-Voigt, or multi-parameter models. Even if these models partially describe the viscoelastic response of disc, all visco…
The importance of level stratification for quantitative MR studies of lumbar intervertebral discs : a cross-sectional analysis in 101 healthy adults
2019
Purpose: To investigate whether quantitative T2-times depend on lumbar intervertebral disc (IVD) level. Methods: The lumbar spine (Th12/L1–L5/S1) of 101 participants (53.5% female, 30.0[± 3.6]years, 173.5[± 9.6]cm and 69.9[± 13.4]kg), without history of back pain, was examined on a 3T scanner with sagittal T2-mapping. All IVDs were stratified according to Pfirrmann grade and lumbar level, with mean T2-time determined for the entire IVD volume and in five subregions of interests. Results: Significant level-dependent T2-time differences were detected, both for the entire IVD volume and its subregions. For the entire IVD volume, Pfirrmann grade 2 IVDs displayed 9–18% higher T2-times in Th12/L1…
Upper thoracic-spine disc degeneration in patients with cervical pain.
2003
To study the relationship of upper thoracic spine degenerative disc contour changes on MR imaging in patients with neck pain. The relation between upper thoracic and cervical spine degenerative disc disease is not well established.One hundred and fifty-six patients referred with cervical pain were studied. There were 73 women and 77 men with a mean age of 48.6 +/- 14.6 years (range, 19 to 83 years). All MR studies were performed with a large 23-cm FOV covering at least from the body of T4 to the clivus. Discs were coded as normal, protrusion/bulge or extrusion.Degenerative thoracic disc contour changes were observed in 13.4% of patients with cervical pain. T2-3 was the most commonly affecte…
Ossovenography and Epidural Venography
1976
Henning (1940) and Ehrhardt and Kneip (1943) were the first to report injection of contrast medium into bone. In 1952 Fischgold et al. reported that contrast injections into a human spinous process resulted in an outline of the venous plexus of the attached vertebral body. In subsequent years improvements have been made which now permit contrast visualization of the venous plexuses of the entire vertebral axis.
Financial Aspects of Cervical Disc Arthroplasty: A Narrative Review of Recent Literature
2020
Recently, there has been significant interest in understanding the cost-effectiveness of treatments in spine surgery as health care systems in the United States move toward value-based care and alternative payment models. Previous studies have shown comparable outcomes of cervical disc arthroplasty (CDA) and anterior cervical discectomy fusion; however, there is a lack of consensus on the cost-effectiveness of CDA to support full adoption. Evidence of the limitations of these cost-analysis studies also exists in the literature, including industry funding, potential selection bias, and varying methods of calculating value. The goal of this narrative review is to provide an overview of the co…
Neurogenic bladder and disc disease: a brief review.
2013
Neurogenic bladder refers to morphofunctional alterations of the bladder-sphincter complex secondary to central or peripheral neurological lesions. Discal etiology can be suggested by clinical observation in patients complaining of classical lower back pain, but not excluded even without musculoskeletal pain. This review provides a brief overview of associations between neurogenic bladder and disc disease, analyzing neuroanatomy, pathophysiology, clinical and urodynamic findings. Therapy is reviewed focusing on etiological treatments.The literature search was performed on PubMed, Medline and Google scholar using the following keywords: 'neurogenic bladder', 'disc herniation', 'disc prolapse…