Search results for "Intrasinusoidal"

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Reply to Pich et al.: intrasinusoidal bone marrow infiltration and splenic marginal zone lymphoma: a quantitative study

2006

Pathologymedicine.medical_specialtybone marrowsplenic marginal zone lymphoma.Bone marrow infiltrationbusiness.industryintrasinusoidalHematologyGeneral Medicineinfiltrationmedicine.diseaseMedicineSplenic marginal zone lymphomabusinessEuropean Journal of Haematology
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CD27 distinguishes two phases in bone marrow infiltration of splenic marginal zone lymphoma.

2004

Aims:  To investigate CD27 expression in splenic marginal zone lymphoma (SMZL), an indolent low-grade B-cell lymphoma with constant involvement of the bone marrow, especially with an intrasinusoidal pattern. It is not clear if the neoplastic clone is composed of virgin or somatically mutated B cells. CD27 is reported to be a hallmark of memory B cells. Methods and results:  We evaluated 64 bone marrow biopsy specimens (BMBs) from 36 patients with SMZL for the expression of CD27. For comparison, splenectomy specimens of patients with traumatic splenic rupture or with SMZL were used. All BMBs showed lymphomatous infiltration. When located in the marrow sinusoids, neoplastic cells were CD27– i…

AdultMalePathologymedicine.medical_specialtyHistologybone marrowLymphomaBiopsyNaive B cellsplenic marginal zone lymphomaSplenic NeoplasmSpleenPathology and Forensic MedicineBiopsyintrasinusoidal infiltrationmedicineHumansSplenic marginal zone lymphomaCD27naive and memory B cellsAgedAged 80 and overmedicine.diagnostic_testbusiness.industrySplenic NeoplasmsGeneral MedicineMiddle Agedmedicine.diseaseBone Marrow NeoplasmImmunohistochemistryTumor Necrosis Factor Receptor Superfamily Member 7bone marrow; CD27; intrasinusoidal infiltration; naive and memory B cells; splenic marginal zone lymphomamedicine.anatomical_structureBone marrow neoplasmFemaleBone marrowbusinessBone Marrow NeoplasmsInfiltration (medical)
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Splenic marginal zone lymphoma with or without villous lymphocytes

2004

BACKGROUND Splenic marginal zone lymphoma (SMZL) is a well defined pathologic entity. However, questions regarding the bone marrow infiltration rate, the minimal diagnostic data set, and therapy remain unanswered. METHODS Clinical-pathologic features and outcomes of 57 consecutive patients who had splenomegaly with no clinically significant lymphadenomegaly and who were diagnosed with SMZL with or without (±) villous lymphocytes (VL) were reviewed. RESULTS SMVL ± VL occurred mostly in elderly males (median age, 62 years ± 10 years; male-to-female ratio, (1.85). Anemia was recorded in 49% of patients, and 30% of patients had moderate thrombocytopenia. Leukocytosis and leukopenia were found i…

AdultMaleCancer Researchmedicine.medical_specialtyLymphomaAnemiamedicine.medical_treatmentSplenectomysplenic marginal zone lymphomaGastroenterologyBone marrow biopsyIntrasinusoidalInternal medicinemedicineHumansLymphocytesLeukocytosisSplenic marginal zone lymphomaSurvival rateAgedAged 80 and overLeukopeniabusiness.industrySplenic Neoplasmssplenic marginal zone lymphoma; PrognosisSplenic lymphoma with villous lymphocytesMiddle AgedPrognosismedicine.diseaseSplenic NeoplasmSurgerySurvival Ratemedicine.anatomical_structureOncologySplenectomySplenic lymphoma with villous lymphocyteLymphocyteFemaleBone marrowmedicine.symptombusinessHumanCancer
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