Search results for "Intrinsic"

The Abundant Tegument Protein pUL25 of Human Cytomegalovirus Prevents Proteasomal Degradation of pUL26 and Supports Its Suppression of ISGylation

2018

The tegument of human cytomegalovirus (HCMV) virions contains proteins that interfere with both the intrinsic and the innate immunity. One protein with a thus far unknown function is pUL25. The deletion of pUL25 in a viral mutant (Towne-ΔUL25) had no impact on the release of virions and subviral dense bodies or on virion morphogenesis. Proteomic analyses showed few alterations in the overall protein composition of extracellular particles. A surprising result, however, was the almost complete absence of pUL26 in virions and dense bodies of Towne-ΔUL25 and a reduction of the large isoform pUL26-p27 in mutant virus-infected cells. pUL26 had been shown to inhibit protein conjugation with the in…

2019

Previous research indicates that programmes employing Hellison’s Teaching Personal and Social Responsibility (TPSR) model in physical activity have had a positive impact on youth development by inc...

Graphical metric space: a generalized setting in fixed point theory

2016

Building on recent ideas of Jachymski, we work on the notion of graphical metric space and prove an analogous result for the contraction mapping principle. In particular, the triangular inequality is replaced by a weaker one, which is satisfied by only those points which are situated on some path included in the graphical structure associated with the space. Some consequences, examples and an application to integral equations are presented to confirm the significance and unifying power of obtained generalizations.

Against all odds: anti-IgE for intrinsic asthma?

2013

For many years, pathogenetic concepts and the results of clinical trials supported the view that anti-IgE treatment is specifically effective in allergic asthma. However, there is now growing clinical and mechanistic evidence suggesting that treatment with the anti-IgE antibody omalizumab can be effective in patients with intrinsic asthma. Therefore, large and well-controlled clinical trials with anti-IgE are urgently warranted in patients with intrinsic asthma. In addition, there is a need to find new biomarkers which can identify patients with asthma who respond to anti-IgE treatment.

Measuring intrinsic thickness of rough membranes: application to nanofibrillated cellulose films

2015

Adequate measurement of thickness of sheet-like materials or membranes is most important for quantifying their properties such as density, barrier properties and mechanical strength. Depending on the surface roughness of the membrane, the thickness measured by standard micrometre devices (apparent thickness) may considerably overestimate the actual geometrical mean thickness (intrinsic thickness) required for such purposes. In this work, we present a method for correcting the measured apparent thickness value of thin membranes for their surface roughness, thereby obtaining an improved estimate of the intrinsic thickness. The surface roughness data required for the correction can be obtained…

Fixed points for Geraghty-Contractions in partial metric spaces

2015

We establish some fixed point theorems for mappings satisfying Geraghty-type contractive conditions in the setting of partial metric spaces and ordered partial metric spaces. Presented theorems extend and generalize many existing results in the literature. Examples are given showing that these results are proper extensions of the existing ones. c ©2014 All rights reserved.

Common fixed points for self mappings on compact metric spaces

2013

In this paper we obtain a result of existence of points of coincidence and of common fixed points for two self mappings on compact metric spaces satisfying a contractive condition of Suzuki type. We also present some examples to illustrate our results. Moreover, using the scalarization method of Du, we deduce a result of common fixed point in compact cone metric spaces.

Common fixed points in cone metric spaces

2007

In this paper we consider a notion of g-weak contractive mappings in the setting of cone metric spaces and we give results of common fixed points. This results generalize some common fixed points results in metric spaces and some of the results of Huang and Zhang in cone metric spaces.

The first Chevalley–Eilenberg Cohomology group of the Lie algebra on the transverse bundle of a decreasing family of foliations

2010

Abstract In [L. Lebtahi, Lie algebra on the transverse bundle of a decreasing family of foliations, J. Geom. Phys. 60 (2010), 122–133], we defined the transverse bundle V k to a decreasing family of k foliations F i on a manifold M . We have shown that there exists a ( 1 , 1 ) tensor J of V k such that J k ≠ 0 , J k + 1 = 0 and we defined by L J ( V k ) the Lie Algebra of vector fields X on V k such that, for each vector field Y on V k , [ X , J Y ] = J [ X , Y ] . In this note, we study the first Chevalley–Eilenberg Cohomology Group, i.e. the quotient space of derivations of L J ( V k ) by the subspace of inner derivations, denoted by H 1 ( L J ( V k ) ) .

Weakly \varphi-pairs and common fixed points in cone metric spaces

2009

In this paper we introduce a weak contractive condition, called weakly \varphi-pair, for two mappings in the framework of cone metric spaces and we prove a theorem which ensures existence and uniqueness of common fixed points for such mappings. Also we obtain a result on points of coincidence. These results extend and generalize well-known comparable results in the literature.