Search results for "Intrinsic"
showing 10 items of 386 documents
Mitochondrial function and sirtuin expression in hippocampus of young and old high- and low-capacity runner rats
2016
Introduction: Exercise and aerobic capacity are associated with improved learning in animals and humans. The hippocampus is a brain structure involved in learning and memory. High rates of neurogenesis have been shown to take place in the dental gyrus of hippocampus in response to physical exercise. It is not known whether mitochondrial dysfunction in the hippocampus is responsible for decline in cognitive function associated with low fitness level and aging, and whether intrinsic aerobic capacity is a risk factor for it. Methods: Mitochondrial function was investigated in the hippocampi of young and old highcapacity runner (HCR) and low-capacity runner (LCR) rats using high-performance res…
Participation in dance training in Finland : a study of motives and behavior regulation
2014
According to the self-determination theory (Deci & Ryan, 1985; 2000), motivation mediates the relationship between physical activity participation and well-being. In environments such as classical ballet that are highly controlling and competitive, intrinsic motives towards training and self-determined forms of behavior regulation are especially important. Therefore, the purpose of the current study was to examine the various participation motives and behavior regulations of dance students. A secondary aim was to investigate group differences across age, competitive level and dance form. Altogether 103 dance students from three schools across Southern Finland completed the Physical Activity…
On multivalued weakly Picard operators in partial Hausdorff metric spaces
2015
We discuss multivalued weakly Picard operators on partial Hausdorff metric spaces. First, we obtain Kikkawa-Suzuki type fixed point theorems for a new type of generalized contractive conditions. Then, we prove data dependence of a fixed points set theorem. Finally, we present sufficient conditions for well-posedness of a fixed point problem. Our results generalize, complement and extend classical theorems in metric and partial metric spaces.
Optimal positioning of the humeral component in the reverse shoulder prosthesis.
2014
Total reverse shoulder arthroplasty is becoming more and more the standard therapeutic practice for glenohumeral arthropathy with massive lesions of the rotator cuff. The biomechanical principle of this prosthesis is represented by the reversion of the normal anatomy of the shoulder joint. This non-anatomical prosthesis leads to a medialization of the rotation centre of the glenohumeral joint and also to a distalization of the humeral head. All that causes a deltoid tension increasing so allowing a larger abduction of the arm. Main complications of the reverse shoulder prosthesis are due to the joint instability, the scapular notching and the wear of the polyethylene insert. The main goal o…
Intrinsic spin-orbit interaction in diffusive normal wire Josephson weak links: Supercurrent and density of states
2016
We study the effect of the intrinsic (Rashba or Dresselhaus) spin-orbit interaction in superconductor–nanowire–superconductor (SNS) weak links in the presence of a spin-splitting field that can result either from an intrinsic exchange field or the Zeeman effect of an applied field. We solve the full nonlinear Usadel equations numerically [The code used for calculating the results in this paper is available in https://github.com/wompo/Usadel-for-nanowires] and analyze the resulting supercurrent through the weak link and the behavior of the density of states in the center of the wire. We point out how the presence of the spin-orbit interaction gives rise to a long-range spin triplet supercurr…
A classification of motivation and behavior change techniques used in self-determination theory-based interventions in health contexts
2020
While evidence suggests that interventions based on self-determination theory have efficacy in motivating adoption and maintenance of health-related behaviors, and in promoting adaptive psychological outcomes, the motivational techniques that comprise the content of these interventions have not been comprehensively identified or described. The aim of the present study was to develop a classification system of the techniques that comprise self-determination theory interventions, with satisfaction of psychological needs as an organizing principle. Candidate techniques were identified through a comprehensive review of self-determination theory interventions and nomination by experts. The study…
Finnish teachers’ and students’ programming motivation and their role in teaching and learning computational thinking
2022
Introduction: Despite the growing importance of teaching and learning computational thinking (CT) through programming in schools, research has shown major individual differences in teachers’ instruction emphasis and students’ skills in these topics. Objective: This study aims to shed further light on the role that teachers’ and students’ programming motivation plays in CT. Methods: The topic is approached from the viewpoint of the self-determination theory, which can help to understand teachers’ instruction and students’ learning. Our sample consisted of Finnish Grade 8 teachers (N = 1,853) and students (N = 2,546) who participated in the International Computer and Information Literacy Stud…
A novel intrinsically disordered outer membrane lipoprotein ofAggregatibacter actinomycetemcomitansbinds various cytokines and plays a role in biofil…
2017
Intrinsically disordered proteins (IDPs) do not have a well-defined and stable 3-dimensional fold. Some IDPs can function as either transient or permanent binders of other proteins and may interact with an array of ligands by adopting different conformations. A novel outer membrane lipoprotein, bacterial interleukin receptor I (BilRI) of the opportunistic oral pathogen Aggregatibacter actinomycetemcomitans binds a key gatekeeper proinflammatory cytokine interleukin (IL)-1b. Because the amino acid sequence of the novel lipoprotein resembles that of fibrinogen binder A of Haemophilus ducreyi, BilRI could have the potential to bind other proteins, such as host matrix proteins. However, from th…
Competition between chain scission and branching formation in the processing of high-density polyethylene: effect of processing parameters and of sta…
2009
Two samples of high-density polyethylene with different molecular weight were processed in a batch mixer and the rheological and structural properties were investigated. In particular, the effect of different processing parameters and the eventual presence of different stabilizers were evaluated. Actually, two reactions may occur during processing: branching/crosslinking or chain scission. The results indicate that when the processing conditions promote a scarce mobility of the macromolecular chains (lower temperatures, lower mixing speed, and higher molecular weight), branching is more favored than chain scission. On increasing the mobility of the chain (higher temperature, higher mixing s…
A novel microtubule de-stabilizing complementarity-determining region C36L1 peptide displays antitumor activity against melanoma in vitro and in vivo
2015
AbstractShort peptide sequences from complementarity-determining regions (CDRs) of different immunoglobulins may exert anti-infective, immunomodulatory and antitumor activities regardless of the specificity of the original monoclonal antibody (mAb). In this sense, they resemble early molecules of innate immunity. C36L1 was identified as a bioactive light-chain CDR1 peptide by screening 19 conserved CDR sequences targeting murine B16F10-Nex2 melanoma. The 17-amino acid peptide is readily taken up by melanoma cells and acts on microtubules causing depolymerization, stress of the endoplasmic reticulum and intrinsic apoptosis. At low concentrations, C36L1 inhibited migration, invasion and proli…