Search results for "Iris"

Effects of GLP-1 receptor agonists on myokine levels and pro-inflammatory cytokines in patients with type 2 diabetes mellitus.

2021

Background and aims: To evaluate the change in circulating serum irisin and interleukin-6 (IL-6), in patients with type 2 diabetes mellitus (T2DM) after 6 and 12 months of GLP-1 treatment. Methods and results: Eighty-five patients with T2DM inadequately controlled with insulin or other hypoglycaemic drugs were added to dulaglutide (N° = 44) and liraglutide (N° = 41) treatment. After 6 months of GLP-1 analogues a significant decrease in BMI (p < 0.001), waist circumference (WC) (p < 0.001), fasting blood glucose (p < 0.001), HbA1c (p < 0.001), total cholesterol (p < 0.001), LDL-cholesterol (p = 0.003), triglycerides (p = 0.017), IL-6 (p = 0.045) and a significant increase in s…

The genomic history of the Aegean palatial civilizations

2021

Summary The Cycladic, the Minoan, and the Helladic (Mycenaean) cultures define the Bronze Age (BA) of Greece. Urbanism, complex social structures, craft and agricultural specialization, and the earliest forms of writing characterize this iconic period. We sequenced six Early to Middle BA whole genomes, along with 11 mitochondrial genomes, sampled from the three BA cultures of the Aegean Sea. The Early BA (EBA) genomes are homogeneous and derive most of their ancestry from Neolithic Aegeans, contrary to earlier hypotheses that the Neolithic-EBA cultural transition was due to massive population turnover. EBA Aegeans were shaped by relatively small-scale migration from East of the Aegean, as e…

The Downside of an Effective cART: The Immune Restoration Disease

2013

The prognosis of patients infected with human immunodeficiency virus (HIV) type 1 has dramatically improved since the advent of the highly active antiretroviral therapy (HAART), which have enabled sustained suppression of HIV replication and recovery of CD4+ T cells count [1-3]. However, many patients in resource-poor settings still start HAART at a late stage of HIV infection when they already have advanced immunodeficien‐ cy [4,5]. Immune reconstitution in HIV infected patients is characterized by replenishment of immune cells depleted directly or indirectly by HIV infection, by regeneration of primary and secondary lymphoid organs, by restoration of pathogen-specific T, B and NK cells an…

Dictamen del Claustro de Medicina de la Uniuersidad de Valencia sobre cemeterios : dado en virtud de proposicion hecha ... en su Ayuntamiento de 8 de…

Dictamen del Claustro de Medicina de la Uniuersidad de Valencia sobre cemeterios : dado en virtud de proposicion hecha ... en su Ayuntamiento de 8 de…

1786

Northern Ireland: Sectarianism, Civil Society and Democratic Deepening

2013

The main aim of this chapter is to provide an overview and evaluation of evidence of efforts at peace-building at the level of civil society (rather than political processes, where most analyses have focused) in Northern Ireland, particularly since the Good Friday Agreement (GFA) of 1998. How successful have attempts, at the level of civil society, by the people of Northern Ireland, the Irish and British governments, the EU and US governments and other actors been in creating community cohesion in a society with a long history of social and political division? In particular, what has been the role of cross-community and religious groups in these efforts? A second aim is to begin to articula…

Derek Mahon's Literal Littorals

2012

International audience; A transversal reading of Derek Mahon's poems reveals his predilection for coastal landscapes: vistas of sea and seashore, harbour towns or seaside resorts. Suffused as they are with elemental symbolism (waves, wind, rain and storm, rocks, cliffs and misty piers), those liminal spaces take on a metaphysical dimension. The landscapes that the poet invests are the objective correlatives of his sense of alienation and vulnerability; they are mindscapes (paesagio mentale or reflections of the inner self) as much as territories to be paced and explored. This paper thus examines how the natural and the urban, the visual and the acoustic, the a-temporal and the modern or pos…

Ambivalent Déjà-vu: World War II in the poetry of the Northern Irish Troubles

2021

This article addresses how the poetry of the Northern Irish Troubles enters into a dialogue with the memory of World War II. Poems by Michael Longley, Seamus Heaney, Derek Mahon, and Sinéad Morrissey are analysed, showing how World War II is a controversial source of comparison for these poets. While World War II provides important ways of framing the suffering and claustrophobia of the Northern Irish conflict, evident differences also mean that such comparisons are handled warily and with some irony. The poems are highly self-conscious utterances that seek to unsettle and develop generic strategies in the light of traumatic suffering. This essay draws on Michael Rothberg’s concept of mult…

The International Comparable Corpus: Challenges in building multilingual spoken and written comparable corpora

2021

This paper reports on the efforts of twelve national teams in building the International Comparable Corpus (ICC; https://korpus.cz/icc) that will contain highly comparable datasets of spoken, written and electronic registers. The languages currently covered are Czech, Finnish, French, German, Irish, Italian, Norwegian, Polish, Slovak, Swedish and, more recently, Chinese, as well as English, which is considered to be the pivot language. The goal of the project is to provide much-needed data for contrastive corpus-based linguistics. The ICC corpus is committed to the idea of re-using existing multilingual resources as much as possible and the design is modelled, with various adjustments, on t…

L'Irlanda e il mito di Daniel O'Connell nelle pagine della rivista francese Correspondant

2014

The liberal French magazine «Correspondant» has historically devoted some articles to the Irish political history and to the Irish “Liberator” and “Emancipator” Daniel O’Connell. Charles de Montalembert, who was named «O’Connell’s pupil» by French liberal Catholics, played a part in the first series of the French magazine. This appeared in 1829 as an organ of the Association pour la défense de la religion catholique. Among the editors’ goals there were: the truth, Catholicism, the independence and alliance of faith and freedom. In 1843, after a few years of inactivity, the «Correspondant» resumed publication and Montalembert returned to work in this second edition, supporting in his writing…