Search results for "Isoindole"

showing 10 items of 83 documents

CCDC 835503: Experimental Crystal Structure Determination

2012

Related Article: B.Maggio, D.Raffa, M.V.Raimondi, F.Plescia, M.L.Trincavelli, C.Martini, F.Meneghetti, L.Basile, S.Guccione, G.Daidone|2012|Eur.J.Med.Chem.|54|709|doi:10.1016/j.ejmech.2012.06.028

Space GroupCrystallographyCrystal SystemCrystal Structure4'-Hydroxy-25'-dimethyl-2'-(4-methylphenyl)-2'4'-dihydrospiro[isoindole-13'-pyrazol]-3(2H)-oneCell ParametersExperimental 3D Coordinates
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CCDC 1057565: Experimental Crystal Structure Determination

2015

Related Article: Melinda Nonn, Loránd Kiss, Matti Haukka, Santos Fustero, Ferenc Fülöp|2015|Org.Lett.|17|1074|doi:10.1021/acs.orglett.5b00182

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters(1aR*2aS*5aR*6aS*)-1-((4-Methylphenyl)sulfonyl)hexahydroazireno[23-f]isoindole-35(1H4H)-dioneExperimental 3D Coordinates
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CCDC 636829: Experimental Crystal Structure Determination

2007

Related Article: A.Valkonen, T.Lahtinen, K.Rissanen|2007|Acta Crystallogr.,Sect.E:Struct.Rep.Online|63|o472|doi:10.1107/S1600536806054870

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters2-(2-Iodoethyl)isoindole-13-dioneExperimental 3D Coordinates
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CCDC 2011186: Experimental Crystal Structure Determination

2021

Related Article: Attila Márió Remete, Tamás T Novák, Melinda Nonn, Matti Haukka, Ferenc Fülöp, Loránd Kiss|2020|Beilstein J.Org.Chem.|16|2562|doi:10.3762/bjoc.16.208

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters2-benzyl-5-fluoro-6-iodohexahydro-1H-isoindole-13(2H)-dioneExperimental 3D Coordinates
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CCDC 1861404: Experimental Crystal Structure Determination

2019

Related Article: Sujoy Das, Kari Rissanen, and Prithidipa Sahoo|2019|ACS Omega|4|5270|doi:10.1021/acsomega.9b00053

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D CoordinatesN-{2-[3'6'-bis(diethylamino)-3-oxospiro[isoindole-19'-xanthen]-2(3H)-yl]ethyl}-2-[(quinolin-8-yl)oxy]acetamide
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CCDC 1530419: Experimental Crystal Structure Determination

2017

Related Article: Sujoy Das, Himadri Sekhar Sarkar, Md Raihan Uddin, Kari Rissanen, Sukhendu Mandal, Prithidipa Sahoo|2017|Chem.Commun.|53|7600|doi:10.1039/C7CC02935G

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersN-{2-[3'6'-bis(diethylamino)-3-oxospiro[isoindole-19'-xanthen]-2(3H)-yl]ethyl}-2-[(naphthalen-1-yl)oxy]acetamideExperimental 3D Coordinates
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CCDC 1518110: Experimental Crystal Structure Determination

2017

Related Article: Jamal Lasri, Bruno Pedras, Matti Haukka, Mário N. Berberan-Santos|2017|Polyhedron|133|195|doi:10.1016/j.poly.2017.05.036

Space GroupCrystallographyCrystal SystemCrystal Structurechloro-[NN'-(1H-isoindole-13(2H)-diylidene)bis(ethanimidamidato)]-platinum(ii)Cell ParametersExperimental 3D Coordinates
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CCDC 916244: Experimental Crystal Structure Determination

2013

Related Article: Santos Fustero, Ignacio Ibáñez, Pablo Barrio, Miguel A. Maestro, Silvia Catalán|2013|Org.Lett.|15|832|doi:10.1021/ol3035142

Space GroupCrystallographyCrystal Systemt-Butyl 1-(35-difluorobenzyl)-3-(trifluoromethyl)-13-dihydro-2H-isoindole-2-carboxylateCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 2041025: Experimental Crystal Structure Determination

2021

Related Article: Goulielmina Anyfanti, Antonio Bauzá, Lorenzo Gentiluomo, João Rodrigues, Gustavo Portalone, Antonio Frontera, Kari Rissanen, Rakesh Puttreddy|2021|Frontiers in Chemistry|9||doi:10.3389/fchem.2021.623595

Space GroupCrystallographybis(2-bromo-1H-isoindole-13(2H)-dione) 1357-tetraazatricyclo[3.3.1.137]decaneCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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Synthesis, benzodiazepine receptor binding and molecular modelling of isochromeno[4,3-c]pyrazol-5(1H)-one derivatives

2012

Abstract A series of isochromeno[4,3-c]pyrazole-5(1H)-one derivatives 7b–h were prepared and tested at 10 μM for their ability to displace specific [3H]flunitrazepam from bovine brain membranes. The substitution pattern of the above derivatives was shown to influence the receptor affinity. The most active compound of the series was 7e, showing a 54% inhibition of [3H]flunitrazepam binding. Compounds 7a–d,i were compared with the known isomers chromeno[4,3-c]pyrazole-4(1H)-ones 14a–d,i, showing that the isochromene/chromene isomerism influences the activity.

StereochemistryProtein ConformationChemistry Techniques SyntheticIsochromeno[43-c]pirazoles Dihydrospiro[isoindole-13’-pyrazol]-3(2H)- ones Benzodiazepine receptorDrug DiscoverymedicineAnimalsHumansBenzopyransReceptorBenzodiazepine receptor bindingPharmacologyChemistryOrganic ChemistryGeneral MedicineReceptors GABA-ASettore CHIM/08 - Chimica FarmaceuticaMolecular Docking SimulationMembraneBovine brainActive compoundPyrazolesCattleFlunitrazepam bindingFlunitrazepammedicine.drugProtein Binding
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