Search results for "Isolation"
showing 10 items of 582 documents
Postzygotic isolation between the two European subspecies of the house mouse: estimates from fertility patterns in wild and laboratory-bred hybrids
2005
We assessed the fertility (reproductive success, litter size, testis weight, spermatocyte-to-spermatid ratio) of F 1 s and backcrosses between different wild-derived outbred and inbred strains of two mouse subspecies, Mus musculus domesticus and M. m. musculus. A significant proportion of the F 1 females between the outbred crosses did not reproduce, suggesting that female infertility was present. As the spermatocyte-to-spermatid ratio was correlated with testis weight, the latter was used to attribute a sterile vs. fertile phenotype to all males. Segregation proportions in the backcrosses of F 1 females yielded 11 (inbred) to 17% (outbred) sterile males, suggesting the contribution of two …
On the verge of extinction: genetics of the critically endangered Iberian plant species, Borderea chouardii (Dioscoreaceae) and implications for cons…
2005
Borderea chouardii is a relictual and dioecious, strictly sexually reproducing, long-living geophyte of the Dioscoreaceae family. Previous biological and demographic studies have indicated the existence of a uniformly distributed panmictic population of this taxon at the southernmost Spanish pre-Pyrenean mountain ranges where it occurs in rather inaccessible crevices of a single limestone cliff. However, individuals of B. chouardii are spatially subdivided into two subpopulations located, respectively, on the upper and lower parts of the cliff, and vertically separated 150 m. Because of its extreme rarity, B. chouardii was the first Iberian taxon to have a specific conservation plan and has…
Dissimilar molecular and morphological patterns in an introgressed peripheral population of a sand dune species ( Armeria pungens , Plumbaginaceae)
2019
Introgression is a poorly understood evolutionary outcome of hybridisation because it may remain largely undetected whenever it involves the transfer of small parts of the genome from one species to another. Aiming to understand the early stages of this process, a putative case from the southernmost border of the Armeria pungens range from its congener A. macrophylla is revisited following the discovery of a subpopulation that does not show phenotypic signs of introgression and resembles typical A. pungens. We analysed morphometrics, nuclear ribosomal DNA ITS and plastid DNA (trnL‐trnF) sequences, genome size, 45S and 5S rDNA loci‐FISH data and nrDNA IGS sequences. Within the study site, mo…
Influence des facteurs socio-économiques et géographiques sur l'incidence, l'accès aux soins et la survie des femmes atteintes d'un cancer du sein
2012
In developed countries, breast cancer is currently the leading cancer in women in terms of incidence and mortality (standardized rate of 101.5 and 17.7 per 100,000 person-years in 2005, respectively). Many risk factors and prognostic factors have been studied and are well known. Research is under way with regard to every step in the development of breast cancer, but the impact of socio-economic and geographic factors, at the individual and environmental level with regard to the disease have never been studied in France.The general aim of this work was to explore the impact of these factors in different ways to build on our knowledge and to develop practical applications in the primary, seco…
A Prospective Study of Social Isolation, Loneliness, and Mortality in Finland
2016
Objectives. To estimate the simultaneous effects of social isolation and loneliness on mortality. Methods. We analyzed a representative Finnish sample (n = 8650) from the cross-sectional Living Conditions Survey of 1994, with a 17-year follow-up period (1995–2011), by using Cox regression models adjusted for several possible confounding variables. We examined the possible nonlinear threshold effect of social isolation on mortality. Results. The analyses revealed that social isolation predicted mortality even after we controlled for loneliness and control variables. The connection between social isolation and mortality was linear in nature and there was no synergistic effect between social …
Use of walking modifications, perceived walking difficulty and changes in outdoor mobility among community-dwelling older people during COVID-19 rest…
2021
Abstract Background Outdoor mobility enables participation in essential out-of-home activities in old age. Aim To compare changes in different aspects of outdoor mobility during COVID-19 restrictions versus two years before according to self-reported walking. Methods Community-dwelling participants of AGNES study (2017–2018, initial age 75–85) responded to AGNES-COVID-19 postal survey in spring 2020 (N = 809). Life-space mobility, autonomy in participation outdoors, and self-reported physical activity were assessed at both time points and differences according to self-reported walking modifications and difficulty vs. intact walking at baseline were analyzed. Results Life-space mobility and …
A Predictive Model for Automatic Detection of Social Isolation in Older Adults
2017
Social isolation is a problem that is accentuated in the stage of old age. This condition puts at risk the physical and mental integrity of older adults. This paper presents a predictive model for the automatic detection of social isolation in older adults. The predictive model was implemented in a mobile application that monitors communication and mobility activities performed by an older adult. The system also considers demographic aspects to improve the prediction results. The mobile application was also generated for a caregiver who is responsible for receiving notifications about the specific level of social isolation of the older adult. The predictive model was evaluated using an expe…
Effectiveness of appropriate care pathways for frail older adults: a pilot study in Valencia (Spain)
2021
Introduction Frail older adults often have multiple health and social problems [1] but experience reduced care coordination due to fragmented service provision [2], and therefore are in need of integrated care. A comprehensive model integrating the provision of health and psychosocial care can promote health and wellbeing among frail older adults. This study explored the effects of a comprehensive model (APPCARE model) on health and wellbeing, and the healthcare resources use, of +75 frail older adults with complex and co-morbid clinical situations after their hospitalization. Methods Within the APPCARE model, two specific care pathways were designed and piloted in the city of Valencia (Spa…
Association of poverty and social exclusion with body mass index among Special Olympics athletes in Europe.
2016
Objectives To examine the association of a risk of poverty and social exclusion (AROPE), age, and gender with the body mass index (BMI) status of European Special Olympics athletes. Methods BMI records were available for 1905 children and youth and 5517 adults from the Special Olympics International (SOI) Health Promotion database. AROPE was extracted from EU Eurostat statistics. Logistic regression analyses were used to predict BMI status. Results For children/youth and adults, respectively, 9.4 and 6.3% were underweight and 25.3 and 44.6% were overweight/obese. Being underweight was significantly associated with higher AROPE rates. Being female and lower AROPE rates were significantly ass…
Self-reported hearing is associated with time spent out-of-home and withdrawal from leisure activities in older community-dwelling adults.
2015
Background Hearing difficulties are prevalent among older people and can lead to difficulties in social interaction. These difficulties may increase the tendency to remain at home and withdraw from leisure activities. Aims To investigate whether self-reported hearing problems are associated with time spent out-of-home and withdrawal from a leisure activity among older persons. Methods Cross-sectional and longitudinal data on 75- to 90-year-old community-dwelling men and women (n = 767) was used. Self-reports of hearing, diseases, and difficulty walking 2 km were obtained via home interviews at baseline, and withdrawal from a leisure activity via 1- and 2-year follow-up telephone interviews.…